... (Pam3CSK4). Methods: 85 nondialysis CKD patients [mean estimated glomerular filtration rate: 34 (17-90) ml/min/1.73 m 2 ] were divided in 2 groups: 55 nondiabetic CKD patients (CKD group) and 30 patients with diabetic nephropathy (DN group). The two groups were compared with 36 healthy subjects (control...

... tubular growth and the associated molecular signature (including upregulation of TGF-β, senescence, and inflammation) set up the development of diabetic nephropathy and renal failure in part by increasing the susceptibility to AKI, which further promotes hypoxia and apoptosis. Considering the strong...

... to in the content or advertisements. Chronic kidney disease Blood pressure Diabetic nephropathy Non-diabetic nephropathy Albuminuria Proteinuria Chronic kidney disease (CKD) is a major public health challenge [ 1 ]. National estimates from the United States indicate about 13 million people...

...Youssef M.K. Farag; Jamal S. Al Wakeel While the prevalence of diabetes mellitus is increasing worldwide, one third of the diabetic patients will eventually develop chronic kidney disease. The aim of this review is to present the available data on diabetic nephropathy and its complications...

... for progression of cardiovascular disease (CVD) in type 1 diabetic patients with diabetic nephropathy (DN). Our aim was to evaluate EPC numbers in asymptomatic CVD type 1 diabetic patients with or without DN and to study the effect of CVD and medication on EPC numbers. Methods: We examined EPC numbers in 37 type...

... of progression in diabetic nephropathy in type 1 diabetic (T1D) patients. Methods: As a substudy of a 4-year randomized, intervention study evaluating low-protein diet in T1D patients with diabetic nephropathy, 78 patients were studied with yearly measurements of u-NGAL (ELISA, BioPorto). Outcome: Decline...

... was to clarify the hypothesis that proximal tubule (PT) dysfunction may be responsible for early diabetic nephropathy (DN), independently of preceding glomerular endothelial dysfunction. The pattern of endothelial dysfunction and its potential variability was evaluated in two vascular beds, the kidney...

... kidney disease Genetic variation Genome-wide association studies Diabetic nephropathy End-stage renal disease The past decade has witnessed a revolution in the field of genetic research. We have emerged from the realm of early genetic studies, such as linkage analysis and the candidate gene...

... of the association between mild renal dysfunction and the occurrence of these outcomes. Most medical societies involved with kidney disease and diabetes recommend determining the level of urinary albumin excretion as a means of screening for diabetic nephropathy [ 12,13 ]. However, although albuminuria...

...S. Stieglmayr; A. Hayat Khayyat; G. Bodlaj; H. Pieringer; G. Biesenbach Aim: The aim of the present study was to find out any differences in the progression of macroangiopathic diseases and patient survival in diabetic patients with diabetic nephropathy (DN) or diabetic renal vasculopathy (DV...

...B.R. Conway; A.P. Maxwell Diabetic nephropathy is the most common cause of end-stage renal disease in the Western world. There is evidence for a genetic susceptibility to diabetic kidney disease, but despite intensive research efforts it has proved difficult to identify the causative genes...

..., and to determine the clinical significance of urinary liver-type fatty acid binding protein (L-FABP) in diabetic nephropathy. Methods: Fifteen patients with nephrotic syndrome due to diabetic nephropathy and 12 patients with minimal-change nephrotic syndrome (MCNS) were studied. Urinary and serum FFA...

...: Our data indicate that mortality of hemodialysis patients with type-2 diabetic nephropathy is influenced neither by dialyzer flux level nor by biocompatibility. Results are expressed as mean (± 1 standard deviation), unless stated otherwise. Comparison of continuous variables between groups...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Multidetector row computed tomography Coronary artery disease Diabetic nephropathy End-stage renal disease The mortality rate from cardiovascular disease in patients...

...Martin Busch; Sybille Franke; Gunter Wolf; Richard D. Rohde; Günter Stein Background/Aims: The aim of this post-hoc analysis of a prospective study in patients with type 2 diabetic nephropathy was to investigate whether treatment with the angiotensin II type 1 receptor blocker irbesartan leads...

...A.M. El Nahas; H. Abo-Zenah; N.J. Skill; S. Bex; G. Wild; M. Griffin; T.S. Johnson Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney failure, however the mechanisms underlying the characteristic expansion of the extracellular matrix (ECM) in diabetic kidneys remain...