...Javier A. Neyra; John Manllo; Xilong Li; Gordon Jacobsen; Jerry Yee; Lenar Yessayan; for the AKICI Study Group Background: Acute kidney injury (AKI) occurs frequently in septic patients. Albuminuria may play a role as an early marker of septic AKI. The potential association between de novo dipstick...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Chronic kidney...

...Kerry L. Horne; Rebecca Packington; John Monaghan; Timothy Reilly; Christopher W. McIntyre; Nicholas M. Selby Background: Acute kidney injury (AKI) is common in hospitalised patients and is associated with adverse long-term consequences. There is an urgent need to understand these sequelae...

...Shahed Ahmed; Sarah Curtis; Charlotte Hill; Trevor Hine Background: Acute kidney injury (AKI) is common in hospitalized patients. Despite the progress that has been made in the last decade, early identification of AKI cases remains a challenge. In recent years, electronic AKI alert (e-AKI alert...

...Sukru Akyuz; Mehmet Karaca; Tugba Kemaloglu Oz; Servet Altay; Baris Gungor; Baris Yaylak; Selcuk Yazici; Kivilcim Ozden; Gultekin Karakus; Nese Cam Background: Efficacy of intravenous (IV) volume expansion in preventing contrast-induced acute kidney injury (CI-AKI) is well known. However, the role...

...Fiona A.I. Duthie; Paul McGeehan; Sharleen Hill; Richard Phelps; David C. Kluth; Vipin Zamvar; Jeremy Hughes; David A. Ferenbach Background/Aims: Acute kidney injury (AKI) following cardiac surgery is a complication associated with high rates of morbidity and mortality. We compared staging systems...

...Mélanie Godin; Etienne Macedo; Ravindra L. Mehta Acute kidney injury (AKI) is associated with increased mortality, prolonged hospitalization, and renal replacement therapy. Until recently, it was believed that the vast majority of patients recover from AKI without subsequent consequences. It is now...

...Michael Heung; Lakhmir S. Chawla This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). The discussion focuses on subjects that recover from an episode of AKI, most of whom do not receive follow-up nephrology care...

...Zoltán H. Endre Establishing the prognosis for recovery has enormous clinical implications. The appropriate definition of renal recovery depends on the stage of acute kidney injury (AKI). As definitions of AKI have broadened to encompass small increases in serum creatinine, definitions of recovery...

... cutoffs for biomarker concentrations. These limitations are increased by comparison with serum creatinine to define acute kidney injury. The critical problem affecting biomarker performance is patient heterogeneity involving the cause, context (including comorbidity and baseline renal function...

...Mei Tran; Samir M. Parikh Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, and apoptosis. The coordinated...

... can confer protection against diverse forms of tissue damage. However, the fate of pyruvate during the evolution of acute kidney injury (AKI) has remained ill defined. Recent experimental studies have indicated that following either ischemic or nephrotoxic renal injury, marked and sustained pyruvate...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Chronic kidney disease...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Kidney repair Mesenchymal stem cells Microvesicles Renal tubules...

... a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials examining this pathway in ischemia-reperfusion injury in various organ systems, including the kidney. HIF are master regulators and mediate adaptive responses to low oxygen...

...Timothy Ball; Peter A. McCullough Acute kidney injury (AKI) is a common medical problem, especially in patients undergoing cardiovascular procedures. The risk of kidney damage has multiple determinants and is often related to or exacerbated by intravenous or intra-arterial iodinated contrast...

...Esther Peters; Rosalinde Masereeuw; Peter Pickkers Sepsis-associated acute kidney injury (AKI) is associated with a high attributable mortality and an increased risk of developing chronic kidney failure in survivors. As a successful therapy is, as yet, unavailable, a pharmacological treatment...

...Nattachai Srisawat; Raghavan Murugan; John A. Kellum Recent progress in biomarkers represents a paradigm shift in acute kidney injury (AKI) research. Most studies have evaluated the use of these biomarkers for early diagnosis of AKI. However, the role of novel biomarkers in predicting renal...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Apoptosis Cellular senescence Epithelial cell injury Fibrosis Proximal tubule metabolism...

...Kathleen D. Liu Although at present we have developed consensus definitions for acute kidney injury (AKI) and there is a major focus on the treatment and prevention of AKI in high-risk populations, little is known about renal recovery per se and the impact of therapies on renal recovery. Here, we...