Aims: It has been reported that taste acuity for the four primary tastes, sour, sweet, salty and bitter, is impaired in hemodialysis (HD) patients. However, there have been no studies reported on taste acuity of diabetic HD patients. The present study aimed to quantify and compare the taste acuity of diabetic and non-diabetic HD patients, and further to determine if there were correlations between diminished taste acuity and certain blood serum parameters typically askew in hemodialysis patients. Methods: In a test group of 24 diabetic and 24 non-diabetic HD patients matched for age, body mass index and duration of HD, taste acuity for the four tastes was determined by asking patients to identify them at varying concentrations. Results: Statistical analyses indicate that bitter and total taste acuity were significantly impaired in diabetic HD patients. In diabetic HD patients, correlation was found between sweet, salty or total taste acuity and blood urea nitrogen or normalized protein catabolic rate. Conclusions: We conclude that taste acuity is partially impaired in diabetic HD patients, and suggest this contributes to reduced appetite, leading to malnutrition and poor prognoses.

Keywords:
Taste acuity, Diabetes mellitus, Hemodialysis, Malnutrition
1.
Fornari AJ, Avram MM: Altered taste perception in uremia. Trans Am Soc Artif Intern Organs 1978;24:385–388.
2.
Buerger JC, Park HS, Whitlock CP, Schemmel RA: Taste acuity in patients undergoing long-term hemodialysis. Kidney Int 1979;15:49–53.
3.
Fernstrom A, Hylander B, Rossner S: Taste acuity in patients with chronic renal failure. Clin Nephrol 1996;45:169–174.
4.
Atkin-Thor E, Goddard BW, O’ Nion J, Stephen RL, Kolff WJ: Hypogeusia and zinc depletion in chronic dialysis patients. Am J Clin Nutr 1978;1948–1951.
5.
Yukio O, Hideo S: The method of gustatory test by filter-paper disk. Jpn J Otol 1980;83:1071–1082.
6.
Sakai F, Yoshida S, Endo S, Tomita H: Therapeutic efficacy of zinc picolinate in patients with taste disorders. Nippon Jibiinkoka Gakkai Kaiho 1955;98:1135–1139.
7.
Tomita H, Horikawa Y: Dissociated taste disorder. Auris Nasus Larynx 1986;13:17–23.
8.
Shinozato T, Nakai S, Fujita Y, Takai I, Morita H, Nakane K, Maeda K: Determination of Kt/V and protein catabolic rate using pre-and postdialysis blood urea nitrogen concentrations. Nephron 1994;67:280–290.
9.
Vreman HJ, Venter C, Leegwater J, Oliver C, Weiner MW: Taste, smell and zinc metabolism in patients with chronic renal failure. Nephron 1980;26:163–170.
10.
Hurley RS, Hebert LA, Rypien AB: A comparison of taste acuity for salt in renal patients vs. normal subjects. J Am Diet Assoc 1987;87:1531–1534
11.
Bellisle F, Dartois AM, Kleinknecht C, Broyer M: Perception of and preference for sweet taste in uremic children. J Am Diet Assoc 1990;90:951–954
12.
Lowrie EG, Lew NL, Huang WH: Race and diabetes as death risk predictors in hemodialysis patients. Kidney Int Suppl 1992;38:S22–31.
13.
Okuno S, Ishimura E, Kim M, Izumotani T, Otoshi T, Maekawa K, Yamakawa T, Morii H, Inaba M, Nishizawa Y: Change in body mass in male hemodialysis patients: A comparison between diabetics and nondiabetics. Am J Kidney Dis 2001;38:208–211.
14.
Park JS, Jung HH, Yang WS, Kim HH, Kim SB, Park SK, Hong CD: Protein Intake and the nutritional state in patients with pre-dialysis chronic renal failure on unrestricted diet. Korean J Intern Med 1997;12:115–121.
15.
Scanziani R, Dozio B, Bonforte G, Surian M: Nutritional parameters in diabetic patients on CAPD. Avd Perit Dial 1996;12:280–283.
16.
Le Floch JP, Le Lievre G, Verroust J, Philippon C, Peynegre R, Perlemuter L: Factors related to the electric taste threshold in type 1 diabetic patients. Diabet Med 1990;7:526–531.
17.
Hardy SL, Brennand CP, Wyse BW: Taste thresholds of individuals with diabetes mellitus and of control subjects. J Am Diet Assoc 1981;79:286–289.
18.
Griffith IP: Abnormalities of smell and taste. Practitioner 1976;217:1302–1310.
19.
Ciechanover M, Peresecenschi G, Aviram A, Steiner JE: Malrecognition of taste in uremia. Nephron 1980;26:20–22.
20.
Gavalda C, Bagan J, Scully C, Silvestre F, Milian M, Jimerez Y: Renal hemodialysis patients: Oral, salivary, dental and peritoneal findings in 105 adult cases. Oral Dis 1999;5:299–302.
21.
Eggert JV, Siegler RL, Edomkesmalee E: Zinc supplementation in chronic renal failure. Int J Pediatr Nephrol 1982;3:21–24.
© 2003 S. Karger AG, Basel
2004
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