This review is an evidence- and experience-based approach to the management of SLE, particularly its kidney manifestations. Specific protocols in substantial clinical detail are provided for management and monitoring, according to the severity of the SLE manifestations. The protocols are adapted from those used in a major SLE trial. The adaptations are based on subsequent extensive clinical use of these protocols. Also described is the concomitant use of cardio- and kidney-protective therapies to optimize patient outcomes.

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