Chronic kidney disease (CKD) is not a priority on the health agenda in Africa and it remains a ‘forgotten condition’. Most people in Africa do not have access to dialysis or transplantation, if they develop end-stage renal disease. Cardiovascular disease (CVD) and HIV/AIDS enjoy a more prominent profile as a serious cause of morbidity and mortality, but despite the clear links of CVD and HIV with CKD, there has been a failure to highlight the link between chronic illnesses like diabetes, hypertension and HIV/AIDS and both CKD and CVD. Management of chronic illnesses requires a functioning public health system and good links between primary and specialist care. Despite calls to establish CKD prevention programs, there are very few in Africa and they have not been integrated into existing primary healthcare systems. This is aggravated by shortages of both financial and human resources and failure to strengthen health systems managing chronic diseases. The result is that very few people in Africa with CKD are managed early or receive dialysis or transplantation. This article investigates some of the issues impacting on the recognition of CKD as a public health issue, and will also consider some factors which could make CKD a more prominent chronic disease in Africa.

1.
Moosa MR, Kidd M: The dangers of rationing dialysis treatment: the dilemma facing a developing country. Kidney Int 2006;70:1107–1114.
2.
Dirks J, Levin N: Dialysis rationing in South Africa: a global message. Kidney Int 2006;70:982–984.
3.
Grassman AS, Gioberge S, Moeller S, Brown G: ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends. Nephrol Dial Transplant 2005;20:2587–2593.
4.
National Kidney Foundation N: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Am J Kidney Dis 2002;39:S1–S266.
5.
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G: National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: evaluation, classification, and stratification. Ann Intern Med 2003;139:137–147.
6.
Levey A, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostetter TH, Lameire N, Eknoyan G: Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005;67:2089–2100.
7.
Barsoum RS: Epidemiology of ESRD: a worldwide perspective; in El Nahas M (ed): Kidney Disease in the Developing World and Ethnic Minorities. London, Taylor & Francis, 2005, pp 1–13.
8.
Eastwood JB, Conroy RE, Naicker S, West PA, Tutt RC, Plange-Rhule J: Loss of health professionals from sub-Saharan Africa: the pivotal role of the UK. Lancet 2005;365:1893–1900.
9.
El Matri A: End-stage renal disease in Africa; in AFRAN (ed): African Association of Nephrology (AFRAN), Khartoum 2007.
10.
Naicker S: End-stage renal disease in sub-Saharan and South Africa. Kidney Int 2003;63(s83):119–122.
11.
Horton R: The neglected epidemic of chronic disease Lancet 2005;366:1514.
12.
Coresh J, Astor B, Greene T, Eknoyan G, Levey A: Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1–12.
13.
Levey A, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt K-U, Nahas ME, Jaber BL, Jadoul M, Levin A, Powe NR, Rossert J, Wheeler DC, Lameire N, Eknoyan G: Chronic kidney disease as a global public health problem: approaches and initiatives – a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 2007;72:247–259.
14.
Global Forum for Health Research: The 10/90 Report on Health Research 2001–2002. Geneva, Global Forum, 2002.
15.
Abegunde D, Mathers CD, Adam T, Ortegon M, Strong K: The burden and costs of chronic diseases in low-income and middle-income countries. Lancet 2007;307:1929–1938.
16.
Strong K, Mathers C, Leeder S, Beaglehole R: Preventing chronic diseases: how many lives can we save? Lancet 2005;366:1578–1582.
17.
Unal B, Critchley JA, Capewell S: Modelling the decline in coronary heart disease deaths in England and Wales, 1981–2000: comparing contributions from primary prevention and secondary prevention. BMJ 2005;331:614.
18.
Kuulasmaa K, Tunstall-Pedoe H, Dobson A, Fortmann S, Sans S, Tolonen H, Evans A, Ferrario M, Tuomilehto J: Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. Lancet 2000;355:675–687.
19.
Epping-Jordan JE, Galea G, Tukuitonga C, Beaglehole R: Preventing chronic diseases: taking stepwise action. Lancet 2005;366:1667–1671.
20.
Epping-Jordan JE, Pruitt SD, Bengoa R, Wagner EH: Improving the quality of health care for chronic conditions. Qual Saf Health Care 2004;13:299–305.
21.
Katz IJ: An Evaluation of a Chronic Disease Outreach Program (CDOP) – a primary care and tertiary care kidney and cardiovascular prevention, detection and management Program; in School of Public Health. Johannesburg, University of the Witwatersrand, 2009, pp 271.
22.
Katz IJ: International Aid and the Formation of Successful Chronic Kidney Disease Prevention Programs (CKDPP); in Barsoum RS, El Nahas M (eds): Kidney Disease in Ethnic Minorities and the Developing World. New York, Dekker, 2005.
23.
Epping-Jordan JE: Integrated approaches to prevention and control of chronic conditions. Kidney Int 2005;98:S86–S88.
24.
Dodd R: Health and the Millennium Development Goals. Geneva, WHO, 2005, pp 84.
25.
Katz IJ: International aid and medical practice in the less-developed world: doing it right, what can renal organizations learn? Kidney Int 2005;68:S60–S65.
26.
McCoy D, Chopra M, Loewenson R, Aitken J-M, Ngulube T, Muula A, Ray S, Kureyi T, Ijumba P, Rowson M: Expanding access to antiretroviral therapy in sub-Saharan Africa: avoiding the pitfalls and dangers, capitalizing on the opportunities. Am J Public Health 2005;95:18–22.
27.
Sanders DM, Chopra M: Implementing comprehensive and decentralised health systems: the quest for integrated care in post-apartheid South Africa. Int J Integr Care 2001;1:2–10.
28.
Sanders DM, Todd C, Chopra M: Confronting Africa’s health crisis: more of the same will not be enough. BMJ 2005;331:755–758.
29.
Rosen S, Sanne I, Collier A, Simon JL: Rationing antiretroviral therapy for HIV/AIDS in Africa: choices and consequences. PLoS Med 2005;2:e303.
30.
World Health Organization: The innovative care for chronic conditions: building blocks for action; in Global Report. Geneva, WHO, 2002.
31.
Victora CG, Hanson K, Bryce J, Vaughan JP: Achieving universal coverage with health interventions. Lancet 2004;364:1541–1548.
32.
Schneider H, Blaauw D, Gilson L, Nzapfurundi C, Goudge J: Health systems and access to antiretroviral drugs for HIV in southern Africa: service delivery and human resource challenges. Reprod Health Matters 2006;14:12–23.
33.
Gaziano TA, Galea G, Reddy KS: Scaling up interventions for chronic disease prevention: the evidence. Lancet 2007;370:1939–1946.
34.
Kober K, Van Damme W: Scaling up access to antiretroviral treatment in southern Africa: who will do the job? Lancet 2004;364:103–107.
35.
Hongoro C, McPake B: Human resources in health: putting the right agenda back to the front. Trop Med Int Health 2003;8:965–966.
36.
Liese B, Blanchet N, Dussault G: The Human Resource Crisis in Health Services in Sub-Saharan Africa in Background Paper. Washington, The World Bank, 2003.
37.
Chen LC, Evans TG, Anand S, Boufford JI, Brown H, Chowdhury M, Cueto M, Dare L, Dussault G, Elzinga G, Fee E, Habte D, Hanvoravongchai P, Jacobs M, Kurowski C, Michael S, Pablos-Mendez A, Sewankambo N, Solimano G, Stilwell B, de Waal A, Wibulpolprasert S: Human resources for health: overcoming the crisis. Lancet 2004;364:1984–1990.
38.
Van Damme W, Kegels G: Health system strengthening and scaling up antiretroviral therapy: the need for context-specific delivery models (comment on H. Schneider et al.). Reprod Health Matters 2006;14:24–26.
39.
Almaguer M, Herrera R, Alfonso J, Magrans C, Mañalich R, Martinez A: Primary healthcare strategies for the prevention of end-stage renal disease in Cuba. Kidney Int 2005;68:S4–S10.
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