...S. Flunkert; M. Hierzer; T. Löffler; R. Rabl; J. Neddens; S. Duller; E.L. Schofield; M.A. Ward; M. Posch; H. Jungwirth; M. Windisch; B. Hutter-Paier Tauopathies, characterized by hyperphosphorylation and aggregation of tau protein, include frontotemporal dementias and Alzheimer's disease...

... in transgenic models of tauopathy. The aggregates are in dynamic equilibrium with their subunits, so that exogenous tau disappears when its expression is switched off. Once the seeds of aggregation are generated by the foreign tau species, they propagate in a ‘prion-like’ fashion within the cell even after...