...Federico Verde; Edoardo Nicolò Aiello; Eleonora Giacopuzzi Grigoli; Ilaria Milone; Antonella Dubini; Antonia Ratti; Barbara Poletti; Nicola Ticozzi; Vincenzo Silani Objectives: This study aimed at testing whether CSF levels of amyloid β 42 (Aβ 42 ), Aβ 40 , total tau, and phosphorylated tau (P-tau...

...Aidana Massalimova; Ruiqing Ni; Roger M. Nitsch; Marco Reisert; Dominik von Elverfeldt; Jan Klohs Introduction: Increased expression of hyperphosphorylated tau and the formation of neurofibrillary tangles are associated with neuronal loss and white matter damage. Using high-resolution ex vivo...

... patients and in transgenic models of AD-like cerebral amyloidosis and tau pathology. However, the occurrence of T cells in AD brains is still controversial; furthermore, the relationship between T cells and hallmarks of AD pathology (amyloid plaques and neurofibrillary tangles) remains to be established...

... progranulin levels were unrelated to patients' increased CSF levels of total tau, possibly indicating different destructive neuronal processes within FTD neurodegeneration. The patient with the novel GRN missense variant (c.1117C>T, p.P373S) showed substantially decreased CSF levels of progranulin...

..., including Tau hyperphosphorylation and aggregation and cognitive deficits in various AD models. In light of the suggested involvement of Tau missorting in AD synaptotoxity and the dual cytoplasmic and synaptic role of Tau, our recent studies focused on the possible role of Tau in the underlying cascades...

...); neurofibrillary tangles (78%, severe); anterior corticospinal tract degeneration (72%, moderate); spinal ventral root atrophy (65%, moderate); atherosclerosis (35%, mild); β-amyloid (35%, mild); tauopathy/tau inclusions (17%, mild); ventricular dilation (13%, mild); Lewy body formation (11%, mild); microinfarcts...

... of different Aβ and APP peptides. Methods: CSF from DS patients (n = 12) and healthy controls (n = 20) were analyzed for Aβ peptides (Aβ1-42, AβX-38/40/42), secreted APP species (sAPPα/β), biomarkers for AD-like axonal degeneration [total tau (T-tau), phosphorylated tau], microglial activation (YKL-40, CC...

... peptides and tau-protein-derived intracellular paired helical filaments. The diagnosis of Alzheimer's disease is impaired by insufficient sensitivity and specificity of diagnostic methods to visualize these pathological hallmarks over all disease stages. Objective: The established fluorescence marker...

...Barbara Borroni; Alberto Benussi; Maura Cosseddu; Silvana Archetti; Alessandro Padovani Background: The course of frontotemporal dementia (FTD) is heterogeneous and no predictors of survival are currently available. Cerebrospinal fluid (CSF) tau dosage has been demonstrated to be useful...

...Einar M. Sigurdsson Disappointing findings from recent phase III trials on amyloid-β (Aβ) immunotherapy for Alzheimer's disease (AD) have shifted the focus of such treatments to the tau protein. As tau pathology correlates better with the degree of dementia than Aβ plaque burden, it is a more...

...Elliott J. Mufson; Sarah Ward; Lester Binder Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. Here, we review data suggesting that prefibrillar tau oligomers mediate cognitive...

... regarding its potential mechanistic implications. Objective: The aim of this study was to review the relative importance of Lewy-related α-synuclein and Alzheimer's tau and amyloid-β (Aβ) pathologies in disease progression and dementia in PD. Methods: We reviewed studies conducted at the Queen Square Brain...

... features of AD also include a decline in synapse number, axonal dystrophies, mitochondrial hypometabolism and increased oxidative stress. It is assumed that the aggregates of amyloid-β and tau are not the major pathogenic players in AD, but that nonaggregated oligomeric forms of amyloid-β and specific...

...-mimetic treatment on AICD-mediated AD-like pathologies remain to be elucidated. Objective: To study the effects of an apoE mimetic (COG112) on neuroinflammation, hyperphosphorylation of tau and defects in adult neurogenesis in AICD- overexpressing transgenic mice (FeCγ25 line). Methods: Beginning at 1...

...S. Flunkert; M. Hierzer; T. Löffler; R. Rabl; J. Neddens; S. Duller; E.L. Schofield; M.A. Ward; M. Posch; H. Jungwirth; M. Windisch; B. Hutter-Paier Tauopathies, characterized by hyperphosphorylation and aggregation of tau protein, include frontotemporal dementias and Alzheimer's disease...

...Maj-Linda B. Selenica; Milene Brownlow; Jeffy P. Jimenez; Daniel C. Lee; Gabriela Pena; Chad A. Dickey; Marcia N. Gordon; Dave Morgan Background: We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau...

.... Apolipoprotein E Neuroprotection Anti-inflammatory activity SET (or I 2 PP2A ) Protein phosphatase 2A Dephosphorylation Neurofibrillary tangles Tau Amyloid Amyloid-β peptide Alzheimer’s disease National Institutes of Health (NIH) 10.13039/100000002 Diseases Neurodegenerative Dis...

... with diffuse staining of phosphorylated tau protein. In PD, increased immunoreactivity for UPR activation markers is detected in neuromelanin containing dopaminergic neurons of the substantia nigra, which colocalize with diffuse α-synuclein staining. Conclusion: UPR activation is closely associated...

... diagnostic utility and compare it with two known CSF markers, 14-3-3 and tau. Methods and Results: We tested CSF levels of 14-3-3, tau and desmoplakin in 58 sCJD patients and 81 control patients including 45 cases with an elevated 14-3-3 level due to other disease than sCJD. We detected an elevated CSF level...

...Hans Zempel; Eva-Maria Mandelkow Background: In Alzheimer’s disease (AD), amyloid-β (Aβ) is the major component of extracellular plaques, whereas the microtubule-associated protein tau forms the main component of intracellular tangles. In contrast to frontotemporal dementias and other...