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Keywords: Tau
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Journal Articles
Neurodegener Dis (2022) 22 (2): 83–86.
Published Online: 24 January 2023
...Federico Verde; Edoardo Nicolò Aiello; Eleonora Giacopuzzi Grigoli; Ilaria Milone; Antonella Dubini; Antonia Ratti; Barbara Poletti; Nicola Ticozzi; Vincenzo Silani Objectives: This study aimed at testing whether CSF levels of amyloid β 42 (Aβ 42 ), Aβ 40 , total tau, and phosphorylated tau (P-tau...
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Neurodegener Dis (2016) 16 (1-2): 22–25.
Published Online: 10 November 2015
..., including Tau hyperphosphorylation and aggregation and cognitive deficits in various AD models. In light of the suggested involvement of Tau missorting in AD synaptotoxity and the dual cytoplasmic and synaptic role of Tau, our recent studies focused on the possible role of Tau in the underlying cascades...
Journal Articles
Neurodegener Dis (2015) 15 (5): 301–312.
Published Online: 16 July 2015
...); neurofibrillary tangles (78%, severe); anterior corticospinal tract degeneration (72%, moderate); spinal ventral root atrophy (65%, moderate); atherosclerosis (35%, mild); β-amyloid (35%, mild); tauopathy/tau inclusions (17%, mild); ventricular dilation (13%, mild); Lewy body formation (11%, mild); microinfarcts...
Journal Articles
Neurodegener Dis (2014) 14 (2): 98–106.
Published Online: 27 June 2014
... of different Aβ and APP peptides. Methods: CSF from DS patients (n = 12) and healthy controls (n = 20) were analyzed for Aβ peptides (Aβ1-42, AβX-38/40/42), secreted APP species (sAPPα/β), biomarkers for AD-like axonal degeneration [total tau (T-tau), phosphorylated tau], microglial activation (YKL-40, CC...
Journal Articles
Neurodegener Dis (2014) 13 (4): 209–213.
Published Online: 25 September 2013
... peptides and tau-protein-derived intracellular paired helical filaments. The diagnosis of Alzheimer's disease is impaired by insufficient sensitivity and specificity of diagnostic methods to visualize these pathological hallmarks over all disease stages. Objective: The established fluorescence marker...
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Journal Articles
Neurodegener Dis (2014) 13 (2-3): 103–106.
Published Online: 11 September 2013
...Einar M. Sigurdsson Disappointing findings from recent phase III trials on amyloid-β (Aβ) immunotherapy for Alzheimer's disease (AD) have shifted the focus of such treatments to the tau protein. As tau pathology correlates better with the degree of dementia than Aβ plaque burden, it is a more...
Journal Articles
Journal Articles
Neurodegener Dis (2014) 13 (2-3): 151–153.
Published Online: 11 September 2013
...Elliott J. Mufson; Sarah Ward; Lester Binder Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. Here, we review data suggesting that prefibrillar tau oligomers mediate cognitive...
Journal Articles
Neurodegener Dis (2013) 12 (3): 111–124.
Published Online: 28 September 2012
... features of AD also include a decline in synapse number, axonal dystrophies, mitochondrial hypometabolism and increased oxidative stress. It is assumed that the aggregates of amyloid-β and tau are not the major pathogenic players in AD, but that nonaggregated oligomeric forms of amyloid-β and specific...
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Journal Articles
Neurodegener Dis (2013) 11 (4): 165–181.
Published Online: 10 July 2012
...Maj-Linda B. Selenica; Milene Brownlow; Jeffy P. Jimenez; Daniel C. Lee; Gabriela Pena; Chad A. Dickey; Marcia N. Gordon; Dave Morgan Background: We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau...
Journal Articles
Neurodegener Dis (2012) 10 (1-4): 122–126.
Published Online: 09 February 2012
.... Apolipoprotein E Neuroprotection Anti-inflammatory activity SET (or I 2 PP2A ) Protein phosphatase 2A Dephosphorylation Neurofibrillary tangles Tau Amyloid Amyloid-β peptide Alzheimer’s disease National Institutes of Health (NIH) 10.13039/100000002 Diseases Neurodegenerative Dis...
Journal Articles
Neurodegener Dis (2012) 10 (1-4): 212–215.
Published Online: 01 February 2012
... with diffuse staining of phosphorylated tau protein. In PD, increased immunoreactivity for UPR activation markers is detected in neuromelanin containing dopaminergic neurons of the substantia nigra, which colocalize with diffuse α-synuclein staining. Conclusion: UPR activation is closely associated...
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Journal Articles