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Keywords: Pyroglutamate
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Journal Articles

Pyroglutamate-Amyloid-β and Glutaminyl Cyclase Are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion

Subject Area:
Further Areas , Geriatrics and Gerontology , Neurology and Neuroscience
Holger Cynis, Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Michael Ziegler, Birgit Koch, Hans-Ulrich Demuth, Vivian Hook
Journal: Neurodegenerative Diseases
Neurodegener Dis (2014) 14 (2): 85–97.
https://doi.org/10.1159/000358430
Published Online: 18 June 2014
...Holger Cynis; Lydiane Funkelstein; Thomas Toneff; Charles Mosier; Michael Ziegler; Birgit Koch; Hans-Ulrich Demuth; Vivian Hook Background and Aims: N-truncated pyroglutamate (pGlu)-amyloid-β [Aβ(3-40/42)] peptides are key components that promote Aβ peptide accumulation, leading...
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Journal Articles

Pyroglutamate-Modified Amyloid-β Protein Demonstrates Similar Properties in an Alzheimer's Disease Familial Mutant Knock-In Mouse and Alzheimer's Disease Brain

Subject Area:
Further Areas , Geriatrics and Gerontology , Neurology and Neuroscience
Guoxin Wu, Ronald A. Miller, Brett Connolly, Jacob Marcus, John Renger, Mary J. Savage
Journal: Neurodegenerative Diseases
Neurodegener Dis (2014) 14 (2): 53–66.
https://doi.org/10.1159/000353634
Published Online: 23 October 2013
...Guoxin Wu; Ronald A. Miller; Brett Connolly; Jacob Marcus; John Renger; Mary J. Savage Background: N-terminally truncated, pyroglutamate-modified amyloid-β (Aβ) peptides are major constituents of amyloid deposits in Alzheimer's disease (AD). Methods: Using a newly developed ELISA for Aβ modified...
View article titled, <span class="search-highlight">Pyroglutamate</span>-Modified Amyloid-β Protein Demonstrates Similar Properties in an Alzheimer&#x27;s Disease Familial Mutant Knock-In Mouse and Alzheimer&#x27;s Disease Brain
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