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Keywords: Presenilin
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Journal Articles
Journal Articles
Journal Articles
Neurodegener Dis (2014) 13 (2-3): 61–63.
Published Online: 02 October 2013
...Jie Shen The presenilin (PS) genes harbor approximately 90% of the identified mutations linked to familial forms of Alzheimer's disease, and the presenilin (PS) proteins are essential components of the γ-secretase complex involved in the proteolytic cleavage of type I receptors, such as Notch...
Journal Articles
Journal Articles
Neurodegener Dis (2010) 7 (1-3): 80–83.
Published Online: 18 February 2010
... systematically the roles of these gene products (e.g. presenilins (PS) for AD; Parkin, DJ-1, PINK1 and LRRK2 for PD) in the mouse brain, especially in neural circuits that are particularly vulnerable in AD or PD. Our series of genetic studies revealed that PS play cell type-specific roles in the developing brain...
Journal Articles
Neurodegener Dis (2010) 7 (1-3): 50–55.
Published Online: 13 February 2010
... referred to as γ-secretase complex that is built up by the association of four distinct proteins, namely presenilin 1 (PS1) or PS2, nicastrin, Aph-1 and Pen-2. AD is also characterized by exacerbated cell death that appears linked to the tumor suppressor p53. Interestingly, all members of the γ-secretase...
Journal Articles
Journal Articles
Neurodegener Dis (2007) 4 (2-3): 112–116.
Published Online: 29 June 2007
...Regina Fluhrer; Christian Haass Signal peptide peptidase (SPP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, which provide the proteolytically active subunit of the γ-secretase complex, SPP...
Journal Articles
Neurodegener Dis (2007) 4 (2-3): 148–155.
Published Online: 29 June 2007
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Notch 1 Presenilin Presynaptic terminals Postsynaptic densities Alzheimer’s disease Cysteine protease Diseases Neurodegenerative Dis 2007;4:148 155 DOI: 10.1159/000101839 Novel...
Journal Articles
Neurodegener Dis (2006) 3 (4-5): 275–283.
Published Online: 13 October 2006
... of γ-secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, γ-secretase was found to be composed of four integral membrane proteins, presenilin (PS), nicastrin (NCT), PEN-2 and APH-1 that are essential and sufficient for γ...
Journal Articles
Neurodegener Dis (2006) 3 (4-5): 284–289.
Published Online: 13 October 2006
...Christof Haffner; Christian Haass Amyloid-β peptide (Aβ) is generated by γ-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit of this complex since...
Journal Articles
Neurodegener Dis (2006) 3 (4-5): 290–297.
Published Online: 13 October 2006
... to in the content or advertisements. Alzheimer’s disease Secretase Aspartic protease BACE inhibitors Presenilin Diseases Original Paper Neurodegenerative Dis 2006;3:290 297 DOI: 10.1159/000095269 Modulators and Inhibitors of - and -Secretases Boris Schmidt Stefanie Baumann Rajeshwar Narlawar Hannes...
Journal Articles
Neurodegener Dis (2006) 3 (4-5): 227–232.
Published Online: 13 October 2006
... somatically expressed presenilin genes that resemble PS1 and PS2 on both a structural and a functional level. Mutations in the sel-12 -encoded presenilin gene cause defective Notch/ lin-12 signaling and result in reduced egg-laying, caused by cell specification and cell attachment defects. spr-1 , spr-3 , spr...
Journal Articles
Journal Articles
Neurodegener Dis (2004) 1 (4-5): 213–217.
Published Online: 15 November 2004
...., USA Key Words Alzheimer s disease W Apolipoprotein E W Amyloid protein precursor W Presenilin Abstract The identification of the apolipoprotein E gene as a risk factor for late-onset Alzheimer s disease was a spectacularly successful application of genetic analysis to a complex trait, and it led...
Journal Articles