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1-16 of 16
Keywords: Presenilin
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Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2014) 13 (2-3): 64–68.
Published Online: 05 November 2013
...Doo Yeon Kim; Mary H. Wertz; Vivek Gautam; Carla D'Avanzo; Raja Bhattacharyya; Dora M. Kovacs Background: Familial Alzheimer's disease (FAD) mutations in presenilin (PS) modulate PS/γ-secretase activity and therefore contribute to AD pathogenesis. Previously, we found that PS/γ-secretase cleaves...
Journal Articles
Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Tetsuaki Arai, Ryozo Kuwano, Takeshi Ikeuchi, Masatoshi Takeda
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2014) 13 (2-3): 166–170.
Published Online: 30 October 2013
...Shinji Tagami; Masayasu Okochi; Kanta Yanagida; Takashi Kodama; Tetsuaki Arai; Ryozo Kuwano; Takeshi Ikeuchi; Masatoshi Takeda Background: Presenilin 1 (PS1) mutations associated with familial Alzheimer disease (FAD) generally increase the amyloid-β 42 (Aβ42) to Aβ40 ratio secreted in cultured...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2014) 13 (2-3): 61–63.
Published Online: 02 October 2013
...Jie Shen The presenilin (PS) genes harbor approximately 90% of the identified mutations linked to familial forms of Alzheimer's disease, and the presenilin (PS) proteins are essential components of the γ-secretase complex involved in the proteolytic cleavage of type I receptors, such as Notch...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2012) 9 (4): 187–198.
Published Online: 08 May 2012
... minocycline in doubly transgenic mice expressing mutant human amyloid precursor protein (APP) and mutant human presenilin-1 (PS1). Results: Minocycline increased the survival of new dentate granule cells in APP/PS1 mice indicated by more BrdU+/NeuN+ cells as compared to vehicle-treated transgenic littermates...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2010) 7 (1-3): 80–83.
Published Online: 18 February 2010
... systematically the roles of these gene products (e.g. presenilins (PS) for AD; Parkin, DJ-1, PINK1 and LRRK2 for PD) in the mouse brain, especially in neural circuits that are particularly vulnerable in AD or PD. Our series of genetic studies revealed that PS play cell type-specific roles in the developing brain...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2010) 7 (1-3): 50–55.
Published Online: 13 February 2010
... referred to as γ-secretase complex that is built up by the association of four distinct proteins, namely presenilin 1 (PS1) or PS2, nicastrin, Aph-1 and Pen-2. AD is also characterized by exacerbated cell death that appears linked to the tumor suppressor p53. Interestingly, all members of the γ-secretase...
Journal Articles
Shinji Tagami, Masayasu Okochi, Akio Fukumori, Jingwei Jiang, Kanta Yanagida, Taisuke Nakayama, Takashi Morihara, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2008) 5 (3-4): 160–162.
Published Online: 06 March 2008
... proteolysis by presenilin (PS)/γ-secretase at least at two sites, near the middle of the TM (γ-/S4 cleavage) and at the interface between cytosol and the TM (Ε-/S3 cleavage), releasing Alzheimer disease (AD)-associated β-amyloid (Aβ)/Notch-1β (Nβ) and βAPP intracellular cytoplasmic domain (AICD)/Notch-1...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2007) 4 (2-3): 112–116.
Published Online: 29 June 2007
...Regina Fluhrer; Christian Haass Signal peptide peptidase (SPP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, which provide the proteolytically active subunit of the γ-secretase complex, SPP...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2007) 4 (2-3): 148–155.
Published Online: 29 June 2007
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Notch 1 Presenilin Presynaptic terminals Postsynaptic densities Alzheimer’s disease Cysteine protease Diseases Neurodegenerative Dis 2007;4:148 155 DOI: 10.1159/000101839 Novel...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2006) 3 (4-5): 275–283.
Published Online: 13 October 2006
... of γ-secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, γ-secretase was found to be composed of four integral membrane proteins, presenilin (PS), nicastrin (NCT), PEN-2 and APH-1 that are essential and sufficient for γ...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2006) 3 (4-5): 284–289.
Published Online: 13 October 2006
...Christof Haffner; Christian Haass Amyloid-β peptide (Aβ) is generated by γ-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit of this complex since...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2006) 3 (4-5): 290–297.
Published Online: 13 October 2006
... to in the content or advertisements. Alzheimer’s disease Secretase Aspartic protease BACE inhibitors Presenilin Diseases Original Paper Neurodegenerative Dis 2006;3:290 297 DOI: 10.1159/000095269 Modulators and Inhibitors of - and -Secretases Boris Schmidt Stefanie Baumann Rajeshwar Narlawar Hannes...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2006) 3 (4-5): 227–232.
Published Online: 13 October 2006
... somatically expressed presenilin genes that resemble PS1 and PS2 on both a structural and a functional level. Mutations in the sel-12 -encoded presenilin gene cause defective Notch/ lin-12 signaling and result in reduced egg-laying, caused by cell specification and cell attachment defects. spr-1 , spr-3 , spr...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2005) 2 (1): 6–15.
Published Online: 10 August 2005
...Xiaoyan Sun; Vassilios Beglopoulos; Mark P. Mattson; Jie Shen Mutations in presenilins (PS) 1 and 2 are the major cause of familial Alzheimer’s disease. Conditional inactivation of PS1 in the mouse postnatal forebrain leads to mild deficits in spatial learning and memory, whereas inactivation...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2004) 1 (4-5): 213–217.
Published Online: 15 November 2004
...., USA Key Words Alzheimer s disease W Apolipoprotein E W Amyloid protein precursor W Presenilin Abstract The identification of the apolipoprotein E gene as a risk factor for late-onset Alzheimer s disease was a spectacularly successful application of genetic analysis to a complex trait, and it led...
Journal Articles
Journal:
Neurodegenerative Diseases
Neurodegener Dis (2004) 1 (4-5): 184–191.
Published Online: 15 November 2004
...Loukia Parisiadou; Angeliki Fassa; Angeliki Fotinopoulou; Ioanna Bethani; Spiros Efthimiopoulos Presenilin-1 (PS1) has gained intensive attention in relation to Alzheimer’s disease, since it has been shown that PS1 mutations are linked to familial Alzheimer’s disease (FAD), and that PS1 is a member...