... to in the content or advertisements. Leukoaraiosis Venous collagenosis Neuropathology Susceptibility-weighted imaging Leukoaraiosis (LA), also known as white matter changes, white matter hyperintensities, or white matter lesions, is a typical neuroimaging feature of cerebral small vessel disease...

.... Neuropathology Neurogenetics Amyotrophic lateral sclerosis Heterogeneous nuclear ribonucleoproteins Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by a loss of upper and lower motor neurons. Clinically, ALS is characterised by rapidly progressive muscle weakness, which...

...Armand Savioz; Panteleimon Giannakopoulos; François R. Herrmann; William L. Klein; Enikö Kövari; Constantin Bouras; Ezio Giacobini Background/Aims: Investigations of Aβ oligomers in neuropathologically confirmed Alzheimer's disease (AD) are still scarce. We report neurohistopathological...

...Reema Paudel; Abi Li; John Hardy; Kailash P. Bhatia; Henry Houlden; Janice Holton Background: Mutations in the thanatos-associated protein domain containing apoptosis-associated protein 1 gene ( THAP1 ) are responsible for adult-onset isolated dystonia (DYT6). However, no neuropathological studies...

...Yasumasa Yoshiyama; Ayako Kojima; Kimiko Itoh; Sagiri Isose; Mizuho Koide; Koji Hori; Kimihito Arai One characteristic neuropathological feature of Alzheimer's disease (AD) is profound neuronal loss in the nucleus basalis of Meynert, the major source of cholinergic innervation of the cerebral...

..., instructions or products referred to in the content or advertisements. Angiitis Amyloid-β Neuropathology Neuroinflammation Angiopathy Primary angiitis of the central nervous system (PACNS) is defined by focal, inflammatory vascular lesions confined to the brain and spinal cord without...

... that PGC-1α dysfunction may contribute to protein misfolding in neurodegeneration. Objective: To systematically evaluate the neuropathological alterations of mice lacking the expression of the full-length PGC-1α protein (FL-PGC-1α) but expressing an N-truncated fragment. Methods: To assess the pattern...

...: The patients with FTLD were heterogeneous concerning age of onset, disease duration, clinical presentation, genetic background and neuropathological typing. Cerebrovascular risk factors and lesions were overall rare in FTLD brains without differences in their prevalence and severity compared to the controls...

... of AD. Our study showed that S100a9 expression was increased in the brains of AD mice and AD patients. In Tg2576 mice, knockdown by short hairpin RNA or knockout of the S100a9 gene significantly reduced the neuropathology, greatly improved the learning and memory impairment and reduced the amount of Aβ...

... to in the content or advertisements. Amyloid Neuropathology Alzheimer’s disease Synapse Diseases Neurodegenerative Dis 2012;10:56 59 DOI: 10.1159/000334762 Received: July 1, 2011 Accepted after revision: October 28, 2011 Published online: January 21, 2012 Intraneuronal A Accumulation, Amyloid Plaques...

... with either the exon 10+3 (24 subjects) or the G335S (1 subject) MAPT mutation, as well as 3 FTDP-17U individuals, who were carriers of the A9D, IVS6-2A>G or R493X PGRN mutation. Neuroimaging studies, obtained along the course of the disease, were compared to the neuropathologic findings. Results: FTDP-17T...