...-mimetic treatment on AICD-mediated AD-like pathologies remain to be elucidated. Objective: To study the effects of an apoE mimetic (COG112) on neuroinflammation, hyperphosphorylation of tau and defects in adult neurogenesis in AICD- overexpressing transgenic mice (FeCγ25 line). Methods: Beginning at 1...

... activation of both the IL-6/gp130 and notch signaling pathway. Although the importance of adult neurogenesis is not clear, glial differentiation of HNPCs may cause problems in maintaining normal brain function and may contribute to the AD pathology. 6 3 2008 Diseases Preamyloid Neurodegenerative...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Erythropoietin Hypoxia Neuroprotection Neuronal regeneration Ischemia Stroke Stem cell therapy Angiogenesis Neurogenesis Diseases Signaling and Stem Cells Neurodegenerative Dis 2006;3:87 93...

.... Use of rat organotypic hippocampal cultures facilitates examination of early signaling events in response to hypoxia and reoxygenation that result in neurogenesis. Cultures were exposed to hypoxia for up to 6 h followed by reoxygenation. CA1 neurons showed focal nuclear condensation by 2 h of hypoxia...