... in neurodegeneration are currently scarce. The effects of age and sex on brain atrophy may not be uniform across the whole brain and may partially explain the sex differences observed in dementia. The current study aimed to examine sex differences in longitudinal atrophy patterns in gray and white matter regions...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2025 Locus coeruleus Alzheimer’s disease Magnetic resonance imaging Sexual dimorphism Noradrenaline Neurodegeneration Alzheimer’s disease (AD) is the most...

... patient care. Summary: This review synthesizes current knowledge of sex-specific differences in MS and NMOSD, with a focus on neuroinflammation and neurodegeneration, as well as cognitive symptoms, and psychiatric comorbidities. The current state of research highlights the role of hormonal changes over...

... ± standard deviation or number (percentage), unless otherwise noted. NA, not available. a Kruskal-Wallis test. b One-way ANOVA. c Chi-square test. Essential tremor Biomarker Neurofilament light Neurodegeneration NIH Essential tremor (ET) is a highly prevalent...

... or advertisements. 2023 SARS-CoV-2 COVID-19 Delirium Acute encephalopathy Dementia Neurodegeneration Neurovascular unit COVID-19 pandemic has impacted our society, requiring urgent action and adaptation, catalyzing the scientific endeavor, and allowing the achievement of solutions...

..., instructions or products referred to in the content or advertisements. Huntington’s disease Mutation carriers Olfactory dysfunction Neurodegeneration Nonmotor symptoms Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by motor, cognitive...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ataxia Neurodegeneration Inborn errors of metabolism Therapy Long-term study Familial isolated deficiency...

... review evidence that (1) excess sucrose consumption induces AD-associated liver pathologies and brain insulin resistance, (2) chronic stress overdrives activity of locus coeruleus neurons, leading to loss of function (a common event in neurodegeneration), (3) high-sugar diets and stress promote the loss...

... to in the content or advertisements. Mouse model Brain-derived neurotrophic factor Neurodegeneration Dorsal root ganglion Cerebellar nucleus Ataxia Iron deposition Mouse models of neurodegenerative diseases are very useful tools in investigating etiology, pathophysiology and treatment...

... and neurodegeneration, and we additionally provide exemplar cases of cerebellar dysfunction in neurodegenerative disorders. Results: Comparisons between normal function and neurodegenerative disease states emphasize how normal organization of the cerebellum is altered in neurodegenerative disease states. We illustrate...

... progranulin levels were unrelated to patients' increased CSF levels of total tau, possibly indicating different destructive neuronal processes within FTD neurodegeneration. The patient with the novel GRN missense variant (c.1117C>T, p.P373S) showed substantially decreased CSF levels of progranulin...

... Biomarker Nigrostriatal system Neurodegeneration Parkinson’s disease Parkinson's disease (PD) is an age-related neurodegenerative disorder associated with a specific pattern of brain pathology including, but not restricted to, a prominent loss of dopaminergic neurons in the substantia nigra...

..., instructions or products referred to in the content or advertisements. Ataxia Parkinson’s disease Progressive supranuclear palsy Activity Sensor Accelerometer Neurogeriatrics Biomarker Outcome parameter Neurodegeneration Neurodegenerative disease Walking With increasingly aging Western...

..., instructions or products referred to in the content or advertisements. Cortical neurons Mast syndrome Maspardin ACP33 SPG21 –/– Neurodegeneration Paraplegia Hereditary spastic paraplegias (HSPs) are a genetically diverse family of disorders presenting a spectrum of symptoms...

... to neurodegeneration. In particular, human haemochromatosis protein (HFE) is involved in iron metabolism, and HFE H63D polymorphism has been related to the risk of amyotrophic lateral sclerosis and Alzheimer's disease. Recently, iron accumulation in the basal ganglia of frontotemporal lobar degeneration (FTLD...

... Magnetic resonance imaging Neurodegeneration Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of amyloid-β (Aβ) plaques, intracellular tau tangles and neurodegeneration leading to progressive cognitive impairment and dementia. During the disease process...

... aggression, loud vocalizations and wandering [ 7 ]. Alzheimer’s disease Sleep disturbances Neurodegeneration REM sleep behaviour disorder Dementia with Lewy bodies We hypothesised that the complexity of SDs is much greater in DLB than previously reported, and that the presence of RBD...

.... Prion disease β-Soluble N-ethylmaleimide-sensitive factor attachment protein Two-dimensional gel electrophoresis Proteomics Neurodegeneration Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), develop as neurodegenerative diseases of the central nervous system...

... ]. In humans, the symptoms which usually appear in the third to fifth decades of life often include cognitive disturbances that can over time develop into dementia [ 3 ]. The primary sites of neurodegeneration are the striatum and cerebral cortex [ 4,5,6,7 ], and neurological investigations suggest that early...

... Parkinson’s disease White matter FMR1 grey-zone alleles Neurodegeneration Fragile X-associated tremor ataxia syndrome (FXTAS) was first described in carriers of premutation (PM) Fragile X mental retardation 1 (FMR1) alleles [ 1 ] containing expansions of the cytosine-guanine-guanine (CGG...