...Iona Pearson; Stella A. Glasmacher; Judith Newton; Emily Beswick; Arpan R. Mehta; Richard Davenport; Siddharthan Chandran; Suvankar Pal; CARE-MND consortium Introduction: Saliva problems are common and distressing for people with motor neuron disease (pwMND). Despite clinical guidelines...

... access to medical records and, until recently, the lack of a national disease registry (the National ALS Registry was created in 2010 but has not yet released any official data regarding incidence rates). Amyotrophic lateral sclerosis Motor neuron disease Incidence Motor neuron diseases...

...), Universidad de Zaragoza, Zaragoza, and b Servicio de Neurología, Unidad de ELA, CIBERER U-723, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain Key Words Amyotrophic lateral sclerosis Motor neuron disease Myogenic regulatory factor Muscle Denervation Abstract...

..., instructions or products referred to in the content or advertisements. Frontotemporal lobar degeneration Motor neuron disease Protein aggregation Amyotrophic lateral sclerosis TDP-43 National Institutes of Health (NIH) 10.13039/100000002 Diseases Modeling Neurodegenerative Diseases...

...: To assess for the first time the presence of TDP43 in a patient with motor neuron disease (MND) and Parkinson’s disease (PD). Methods: A 78-year-old woman developed poorly dopa-responsive parkinsonism without cognitive alteration. Three years later, MND appeared and led to death in less than a year...

... Lawrence J. Hayward Department of Neurology, University of Massachusetts Medical School, Worcester, Mass., USA Key Words Amyotrophic lateral sclerosis Motor neuron disease Copper-zinc superoxide dismutase Protein misfolding Differential scanning calorimetry Abstract The biological basis...

... of difficulties which are currently of major interest for the development of therapeutics. In particular, in the previously untreatable motor neuron diseases, the steps from genes to transgenic animals and finally to the patient have proven difficult. High expectations have not met with the transfer of numerous...