... the distribution of microglial cell activation in 2 neurodegenerative dementias with distinct protein signatures, Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) of the TDP subtype, and to determine if there was an anatomical correlation with the phenotypes most commonly associated...

... to neurodegeneration. In particular, human haemochromatosis protein (HFE) is involved in iron metabolism, and HFE H63D polymorphism has been related to the risk of amyotrophic lateral sclerosis and Alzheimer's disease. Recently, iron accumulation in the basal ganglia of frontotemporal lobar degeneration (FTLD...

... (7%, mild); and α-synuclein (4%, mild). Twenty-two percent of patients met criteria for Alzheimer's disease (AD) and 26% for frontotemporal lobar degeneration. Substantial differences were identified in the AD group and in the different onset age groups. Conclusion: Our findings support...

...Rita Gaspar; Isabel Santana; Cândida Mendes; Ana Sofia Fernandes; Diana Duro; Marta Simões; Daniela Luís; Maria João Santos; Manuela Grazina Background: Frontotemporal lobar degeneration (FTLD) is the second most common early-onset dementia. Over the last few decades, a growing number of evidence...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Dementia ELISA Frontotemporal lobar degeneration Frontotemporal lobe dementia Tau Frontotemporal dementia...

... workload and should be extended to other clinical phenotypes than behavioral variant frontotemporal dementia and to apparently sporadic cases. Serum progranulin Frontotemporal lobar degeneration Alzheimer’s disease Progranulin mutation The study population consisted of 244 individuals...

..., implying additional vascular factors in the pathogenesis of Alzheimer’s dementia. The aim of the study was to investigate the impact of cerebrovascular pathology on brains with frontotemporal lobar degeneration (FTLD). Patients and Methods: Twenty-two brains with autopsy-proven FTLD were compared to 15...

..., attention was drawn to a role for progranulin in the central nervous system with the identification of mutations in the progranulin gene (GRN) as an important cause of frontotemporal lobar degeneration. GRN mutations are associated with a strong reduction of circulating progranulin and widely variable...

...B. Borroni; M. Grassi; S. Archetti; A. Papetti; R. Del Bo; C. Bonvicini; G.P. Comi; M. Gennarelli; G. Bellelli; M. Di Luca; A. Padovani Background: Ruling out predictors of survival in frontotemporal lobar degeneration (FTLD) is a clinical challenge for defining disease outcomes and monitoring...

...Iga Wegorzewska; Robert H. Baloh The clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) suggests these diseases share common underlying mechanisms, a suggestion underscored by the discovery that TDP-43 inclusions are a key...

...Jennifer L. Whitwell; Clifford R. Jack, Jr.; Matthew L. Senjem; Joseph E. Parisi; Bradley F. Boeve; David S. Knopman; Dennis W. Dickson; Ronald C. Petersen; Keith A. Josephs Background: Frontotemporal lobar degeneration (FTLD) can be classified based on the presence of the microtubule-associated...

... and PINK1. Several genes have been implicated in Alzheimer disease, including the APP gene and the PSEN genes. Recently, variants in the sortilin-related receptor 1 gene, SORL1, were associated with Alzheimer disease. Alzheimer disease Dementia Frontotemporal dementia Frontotemporal lobar degeneration...

...Julie van der Zee; Ilse Gijselinck; Daniel Pirici; Samir Kumar-Singh; Marc Cruts; Christine Van Broeckhoven Frontotemporal lobar degeneration (FTLD) is a clinically, pathologically and genetically highly complex disorder. In the last few years enormous progress has been made in dissecting...

...Jennifer L. Whitwell; Jason D. Warren; Keith A. Josephs; Alison K. Godbolt; Tamas Revesz; Nick C. Fox; Martin N. Rossor Background: The identification of specific, diagnostically useful predictors of protein dysfunction in the frontotemporal lobar degenerations (FTLD) is a problem of great clinical...