...Ran Chen; Chao Zhou; Yun Peng; Pengcheng Huang; Yanyan Yu; Min Zhu; Meihong Zhou; Daojun Hong; Dandan Tan Introduction: Spinocerebellar ataxia type 36 (SCA36) is caused by large GGCCTG repeat expansion in the NOP56 gene. The genetic diagnosis based on Southern blot is expensive and time-consuming...

... a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families. Summary: This review focuses on the potential of high-sensitivity...

...Helder Vieira; Nelson Costa; Tomás Sousa; Sara Reis; Luis Coelho Background: Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease. People with ALS demonstrate various speech problems. Summary: We aim to provide an overview of studies concerning the diagnosis of ALS based...

...Ana Rita Saldanha Ramos; Carolina Garrett Huntington's disease (HD) is an incurable, neurodegenerative disease, which manifests via a triad of progressive symptoms: motor impairment, psychiatric disorders, and cognitive decline. Conventionally, the HD diagnosis is based on the presence...

...Andreas Kupsch; Nin Bajaj; Frederick Weiland; Antonio Tartaglione; Susanne Klutmann; Ronald Copp; Paul Sherwin; Ann Tate; Igor D. Grachev Background: An accurate diagnosis is important for timely and adequate treatment in patients with clinically uncertain parkinsonian syndrome (CUPS). Objective...

.... Parkinsonߣs disease Nonmotor disturbances Depression Anxiety Fatigue Diagnosis Quality of life Diseases Review Neurodegenerative Dis 2011;8:95 108 DOI: 10.1159/000316613 Received: March 3, 2010 Accepted after revision: May 28, 2010 Published online: December 23, 2010 Nonmotor Disturbances...

... responses to a therapeutic intervention. Expectations are high for the development of biomarkers since they make it possible to achieve a significant improvement in the diagnosis and classification of diseases like Parkinson’s disease. As a surrogate marker for clinical studies, a biomarker can also be used...