... depression to cognitive decline, suggesting depression is an early marker of dementia. We examined whether baseline depressive symptoms predict incident dementia in elders with ET. Methods: Hundred and forty-one ET cases aged 70 years or older at baseline, enrolled in a prospective study of cognitive...

... cognitive concerns without objective cognitive impairment and is considered a risk factor for cognitive decline and dementia. However, most SCD patients will not develop neurodegenerative disorders, yet they may suffer from minor psychiatric, neurological, or somatic comorbidities. The aim of the present...

... factor for developing delirium disorder during COVID-19, which, in turn, increases the risk of subsequent neurological complications and cognitive decline. Summary: The bidirectional connection between delirium disorder and dementia likely resides at multiple levels, and its pathophysiological mechanisms...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Alzheimer APP Neurogenetics Dementia Semi-dominant pattern Alzheimer disease (AD, OMIM#104300) is the most common cause of dementia, accounting for 60–80...

... for patients with advanced dementia. Objectives: To describe and compare physician and surrogate agreement with the use of assisted dying and CDS in advanced dementia. Design, Setting, Subjects: Physicians ( n = 64) and surrogates ( n = 168) of persons with advanced dementia were recruited as part...

... demographic and clinical characteristics, including educational background and history of dementia, diabetes, hypertension, and tobacco use (Table 1 ). A total of 6 patients, including 5 cases and 1 control, had a known diagnosis of dementia. Table 1. Baseline demographics and clinical characteristics...

... level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better...

... and the progression to dementia are still poorly described. The recently revised criteria for PSP consider cognitive dysfunction in the diagnostic work-up. Methods: The study retrospectively evaluated a series of 99 PSP patients with Richardson syndrome (PSP-RS), subgrouped according to cognitive and behavioural...

...Bernhard Cerff; Walter Maetzler; Patricia Sulzer; Malte Kampmeyer; Jos Prinzen; Markus A. Hobert; Dominik Blum; Rob van Lummel; Silvia Del Din; Susanne Gräber; Daniela Berg; Inga Liepelt-Scarfone Background: For the early diagnosis of Parkinson disease dementia (PDD), objective home-based tools...

...Stephen N. Gomperts; Marta Marquie; Joseph J. Locascio; Stephen Bayer; Keith A. Johnson; John H. Growdon Background: Effective therapies for dementia with Lewy bodies (DLB) and Parkinson's disease (PD) dementia will require accurate diagnosis and an understanding of the contribution of distinct...

...Oriol Grau-Rivera; Ellen Gelpi; Carlos Nos; Carles Gaig; Isidro Ferrer; Albert Saiz; Albert Lladó; José L. Molinuevo; Francesc Graus; Raquel Sánchez-Valle; for the Neurological Tissue Bank Collaborative Group Background: Rapidly progressive dementia (RPD) is caused by a heterogeneous group of both...

...Rita Gaspar; Isabel Santana; Cândida Mendes; Ana Sofia Fernandes; Diana Duro; Marta Simões; Daniela Luís; Maria João Santos; Manuela Grazina Background: Frontotemporal lobar degeneration (FTLD) is the second most common early-onset dementia. Over the last few decades, a growing number of evidence...

...Barbara Borroni; Alberto Benussi; Maura Cosseddu; Silvana Archetti; Alessandro Padovani Background: The course of frontotemporal dementia (FTD) is heterogeneous and no predictors of survival are currently available. Cerebrospinal fluid (CSF) tau dosage has been demonstrated to be useful...

...Yaroslau Compta; Laura Parkkinen; Peter Kempster; Mariana Selikhova; Tammaryn Lashley; Janice L. Holton; Andrew J. Lees; Tamas Revesz Background: Dementia is one of the milestones of advanced Parkinson's disease (PD), with its neuropathological substrate still being a matter of debate, particularly...

... carriers, in cognitively normal people who are amyloid positive, and in asymptomatic carriers of autosomal-dominant mutations years before the estimated age of dementia onset [ 4 ]. These findings suggest that the DMN might specifically show abnormalities before amyloid biomarkers become abnormal [ 5...

.... Alzheimer’s disease Amyloid precursor protein Amyloid protein Dementia Mechanism of neurodegenerative diseases Neurodegeneration Protein misfolding The β-amyloid precursor protein (APP) is a 110- to 130-kDa integral type I transmembrane glycoprotein that has been extensively studied for its role...

... treatments, and relate differentially to PD dementia (PDD). We summarise studies conducted in our laboratory over the last 2 decades, outlining the incremental development of our hypotheses, the starting point for which is our early work on executive deficits mirroring fronto-striatal dysfunction. We present...

...: The role of white matter hyperintensities (WMH) and homocysteine (Hcy) and other vascular risk factors in the pathogenesis of Parkinson's disease (PD) dementia (PDD) remains unclear. Objective: The aim of the study was to assess the impact of WMH, Hcy and other biochemical and vascular risk factors on PDD...

...: To identify changes in regional fMRI-BOLD activity that tracks change in neuropsychological performance in mild AD dementia over 6 months. Methods: Twenty-four subjects (mean age 71.6) with mild AD dementia (mean Mini Mental State Examination 21.7, Global Clinical Dementia Rating 1.0) on stable donepezil...

... or dementia. Methods: We combined the results from two cohort studies graphically and conducted additional analyses. Results: Combined results from the Mayo Clinic Cohort Study of Oophorectomy and Aging and from a Danish nationwide cohort study suggest that the extent of gynecologic surgery may correlate...