... from any ideas, methods, instructions or products referred to in the content or advertisements. Alzheimer disease Amyloid peptide Amyloid precursor protein Secretase Sorting nexin Alzheimer disease (AD) is a complex and progressive neurodegenerative disease. Although the molecular...

... expressing human β-Syn were injected into the hippocampus of transgenic mice overexpressing human amyloid precursor protein with Swedish and London mutations (APP SL ). An empty vector served as the control. Behavioral analyses were performed 1, 3 and 6 months after injection followed by biochemical...

... ageing Amyloid precursor protein Amyloid-β Brain Immunoprecipitation Mass spectrometry Alzheimer's disease (AD) is a neurodegenerative disease affecting around 10% of people over 65 years of age. It is characterized pathologically by extracellular deposits of amyloid-β (Aβ) in senile plaques...

... this extract reduces Aβ levels. Methods: We tested P. erinaceus extract at non-toxic concentrations on cells expressing the human amyloid precursor protein (APP695) or its amyloidogenic β-cleaved C-terminal fragment (C99), as well as on neuronal cell lines. P. erinaceus extract was found to inhibit Aβ release...

...(OH) vitamin D 3 on amyloid precursor protein processing in mice and N2A cells utilizing very moderate and physiological vitamin D hypovitaminosis in the range of 20-30% compared to wild-type mice. We found that already under such mild conditions, amyloid-β peptide (Aβ) is significantly increased...

... at glutamate 3 with a pyroglutamate (pE3Aβ), brain pE3Aβ was characterized in human AD in an AD mouse model harboring double knock-in amyloid precursor protein (APP)-KM670/671NL and presenilin 1 (PS1)-P264L (APP/PS1-dKI) mutations, and in a second mouse model with transgenic overexpression of human APP695...

... of the mechanisms that instruct neural stem cell behaviour, such as proliferation and cell fate specification. The β-amyloid precursor protein (APP) of Alzheimer's disease (AD) may play an important role in neural stem cell proliferation and differentiation. Our recent work shows that in vitro, APP stimulates...

...Inna Rabinovich-Nikitin; Beka Solomon Background and Methods: We previously reported the development of site-directed monoclonal antibodies able to inhibit the initiation of the amyloid precursor protein (APP) processing site, named ‘blocking β site 1' (BBS1). The beneficial effect...

... of mitochondria from the neuronal soma, and a tight regulation of anterograde and retrograde transport (for recycling and degradation) of mitochondria and mitochondrial components. Amyloid precursor protein Axonal transport Mitochondria Oxidative stress Tau 13 03 2012 19 07 2012 28 9...

...Kaushik Ghosal; Andrea Stathopoulos; Dustin Thomas; David Phenis; Michael P. Vitek; Sanjay W. Pimplikar Background: Amyloid-β (Aβ) peptides derive from the amyloid precursor protein (APP) and play a pivotal role in Alzheimer's disease (AD) pathogenesis. Our previous work showed that the APP...

... minocycline in doubly transgenic mice expressing mutant human amyloid precursor protein (APP) and mutant human presenilin-1 (PS1). Results: Minocycline increased the survival of new dentate granule cells in APP/PS1 mice indicated by more BrdU+/NeuN+ cells as compared to vehicle-treated transgenic littermates...

...N. Ben Khalifa; D. Tyteca; P.J. Courtoy; J.C. Renauld; S.N. Constantinescu; J.N. Octave; P. Kienlen-Campard Background: The two major isoforms of the human amyloid precursor protein (APP) are APP695 and APP751. They differ by the insertion of a Kunitz-type protease inhibitor (KPI) sequence...

... or delay the onset of AD, what is the responsible mechanism? Methods: We investigated the effect of fluvastatin on Aβ metabolism at a clinically relevant dose in mice. Results: Fluvastatin reduced the brain Aβ level by increased trafficking of the carboxyl terminal fragment of the amyloid precursor protein...

...Polina Rabinovich-Toidman; Maria Becker; Beika Barbiro; Beka Solomon Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease defined by motor neuron loss. Recent studies have reported an increase in amyloid precursor protein (APP) levels and in its cleavage...

... protein TASTPM Alzheimer’s disease Diseases Original Paper Neurodegenerative Dis 2011;8:15 24 DOI: 10.1159/000313903 Received: December 21, 2009 Accepted after revision: April 15, 2010 Published online: August 4, 2010 TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes...

.... This process has been called ‘molecular misreading’. In the present review, we will discuss the present state of the art with regard to UBB +1 and amyloid precursor protein APP +1 . 18 2 2010 © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... migrate and differentiate due to environmental cues received from the host, allowing for intrinsic proper functioning of the cells. Thus, we have to consider the effects that the pathological environment might have on the transplanted cells. Here, we show the effects of amyloid precursor protein...

... abnormalities in animal models overexpressing amyloid precursor protein seem independent of amyloid depositions. Soluble Aβ theories propose toxic Aβ42 or its oligomers as the agents that promote cell death in AD. Aβ peptides, however, are normal components of human serum and CSF, and it is unclear under what...

...Erik Portelius; Gunnar Brinkmalm; Ai Jun Tran; Henrik Zetterberg; Ann Westman-Brinkmalm; Kaj Blennow Background: Aggregation of β-amyloid (Aβ) into oligomers and plaques is the central pathogenic mechanism in Alzheimer’s disease (AD). Aβ is produced from the amyloid precursor protein (APP) by β...

... incidence of Alzheimer’s disease (AD). Several mechanisms have been proposed to explain these findings including increased shedding of the soluble ectodomain of the amyloid precursor protein (sAPP), which functions as a neurotrophic and neuroprotective factor in vitroand in vivo. Objective: To clarify...