...Federico Verde; Edoardo Nicolò Aiello; Eleonora Giacopuzzi Grigoli; Ilaria Milone; Antonella Dubini; Antonia Ratti; Barbara Poletti; Nicola Ticozzi; Vincenzo Silani Objectives: This study aimed at testing whether CSF levels of amyloid β 42 (Aβ 42 ), Aβ 40 , total tau, and phosphorylated tau (P-tau...

.... The diagnosis of cognitive conditions was made by standard criteria consisting of clinical interviews, physical examinations, cognitive assessments, laboratory examinations, and neuroimaging by both structural neuroimaging and amyloid positron emission tomography scans. Correlations between medical factors...

...Sven Haller; Marie-Louise Montandon; Cristelle Rodriguez; Valentina Garibotto; François R. Herrmann; Panteleimon Giannakopoulos Background: Hippocampal volume loss (HVL), PET-documented brain amyloid accumulation, and APOE-ε4 status are predictive biomarkers of the transition from mild cognitive...

... patients and in transgenic models of AD-like cerebral amyloidosis and tau pathology. However, the occurrence of T cells in AD brains is still controversial; furthermore, the relationship between T cells and hallmarks of AD pathology (amyloid plaques and neurofibrillary tangles) remains to be established...

... transporter, DAT) and Pittsburgh compound B (PiB; β-amyloid). Putamen DAT concentrations were similar in DLB and PD and differentiated them from HCS and AD. Decreased caudate DAT concentration related to functional impairment in DLB but not PD. PiB uptake was greatest in DLB. However, cortical PiB retention...

... of the cerebral blood flow (CBF) measures from ASL-MRI and cerebral metabolic rate for glucose (CMRgl) measures from FDG-PET to distinguish amyloid-β-positive (Aβ+) subjects in the AD continuum from healthy controls. Methods: The study included asymptomatic, cognitively normal (CN) controls and patients...

... visualizing fibrillar amyloid, inflammatory changes including astrocytosis and activation of microglia as well as cerebral glucose metabolism indicate that AD pathological processes are initiated and ongoing decades before the onset of cognitive symptoms. Therefore, prevention might be a new promising target...

...Gunnar K. Gouras; Katarina Willén; Mathilde Faideau Cumulative evidence in brains and cultured neurons of Alzheimer's disease (AD) transgenic mouse models, as well as in human postmortem AD brains, highlights that age-related increases in β-amyloid peptide (Aβ), particularly in endosomes near...

...Annemieke J.M. Rozemuller; Casper Jansen; Anna Carrano; Elise S. van Haastert; David Hondius; Saskia M. van der Vies; Jeroen J.M. Hoozemans Background: In cases with a long (>1 year) clinical duration of prion disease, the prion protein can form amyloid deposits. These cases do not show...

... and biochemical testing. Results: Treatment with apoE mimetics significantly improved behavior while decreasing the inflammatory cytokine IL-6, neurofibrillary tangle-like and amyloid plaque-like structures. Biochemical measures matched the visible pathological results. Conclusions: Treatment with apoE mimetics...

...David H. Small Amyloid-β (Aβ)-induced Ca 2+ influx into neurons has been well described since it was first reported almost 20 years ago. Ca 2+ influx can disrupt mechanisms of long-term potentiation and long-term depression and increase neuronal susceptibility to excitotoxicity. Our studies show...

...Estibaliz Capetillo-Zarate; Luis Gracia; Davide Tampellini; Gunnar K. Gouras Background: β-Amyloid (Aβ) plaques are a pathological hallmark of Alzheimer’s disease (AD) and multiple lines of evidence have linked Aβ with AD. However, synapse loss is known as the best pathological correlate...

... coactivator CREB-regulated transcription coactivator 1 (CRTC1) in control and mutant β-amyloid precursor protein (APP Sw,Ind ; Swedish and Indiana mutations) transgenic mice. Results: Gene expression analyses revealed specific downregulation of a subset of well-known activity-induced CREB-dependent genes...

...Silvia Fossati; Jorge Ghiso; Agueda Rostagno Background: The vascular deposition of amyloid known as cerebral amyloid angiopathy (CAA) – an age-associated condition and a common finding in Alzheimer’s disease – compromises cerebral blood flow, causing macro/microhemorrhages and/or cognitive...

... within the normal range in PreS subjects, or they presented transitional values in AsymR subjects. Overall, these findings suggest that the preclinical stage is biologically active and that there may be structural changes when amyloid is starting its deposition. © 2011 S. Karger AG, Basel 2011...

...Juan Fortea; Albert Lladó; Beatriz Bosch; Anna Antonell; Rafael Oliva; Jose Luis Molinuevo; Raquel Sánchez-Valle Background/Aims: Familial Alzheimer’s disease allows studies in the preclinical phases of the disease. We studied cerebrospinal fluid (CSF) amyloid β1–42 (Aβ1–42), total tau (t-tau...

... to in the content or advertisements. Secretase Amyloid Glycosaminoglycan Heparin Autocatalysis Diseases Treatment and Prevention Neurodegenerative Dis 2010;7:187 189 DOI: 10.1159/000295661 Published online: March 12, 2010 Effect of Heparin on APP Metabolism and A Production in Cortical Neurons David...

... and AChE-S to explore putative interactions with the AD β-amyloid peptide. Results: Our findings demonstrate distinct, and in certain cases inverse cell fate outcome under enforced expression of the human N- and C-terminally modified AChE variants, all of which have similar enzymatic activities. Conclusion...

...Henri J. Huttunen; Dora M. Kovacs Accumulation of β-amyloid peptide (Aβ) in the brain regions responsible for memory and cognitive functions is a neuropathological hallmark of Alzheimer’s disease. Cholesterol may be involved in many aspects of Aβmetabolism. It affects generation, aggregation...

...Agueda Rostagno; Jorge Ghiso The importance of amyloid plaques in the pathogenesis of dementia is usually centered on β-amyloid (Aβ) and its role in Alzheimer’s disease (AD). However, since fibrillar plaques correlate poorly with neurodegeneration, challenging their importance in the mechanism(s...