...) and Alzheimer’s disease (AD), but the specific aspects that are affected, their neuropathology, and potential value for classification modeling is unknown. The current study examined if multiple measures of motor strength, dexterity, and speed are affected in MCI and AD, related to AD biomarkers, and are able...

... cause potentially explaining their SCD. Subjective cognitive decline Alzheimer’s disease Dementia Subjective cognitive decline (SCD) can be defined as the perception of persistent decline in cognitive functions associated with normal performance on standardized cognitive tests [ 1, 2...

... to collect objects from the kitchen or garden) allows to propose olfactory markers. Decision-making algorithm Early screening Remote digital assessment Alzheimer’s disease Digital biomarkers Alzheimer’s disease (AD), characterized by amyloid β and tau pathology, is the main source...

...Luc Nwamekang Belinga; Jeanne Espourteille; Yembe Wepnyu Njamnshi; Ariole Zafack Zeukang; Olivier Rouaud; Alfred Kongnyu Njamnshi; Gilles Allali; Kevin Richetin Background: Alzheimer’s disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating...

... Machine learning Random forest Alzheimer’s disease Mild cognitive impairment Intestinal flora Alzheimer’s disease (AD) is a neurodegenerative disease with high incidence, high mortality, and heavy social burden [ 1 ]. The disease is a continuous pathological process, which can be divided...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Multiple sclerosis Spain-Portugal border Neurodegenerative diseases (hereinafter referred...

...Seong Sool Shim; Ken Berglund; Shan Ping Yu Background: Although Alzheimer’s disease (AD) is the most common form of dementia, the effective treatment of AD is not available currently. Multiple trials of drugs, which were developed based on the amyloid hypothesis of AD, have not been highly...

...Sedef Kollarik; Inês Dias; Carlos G. Moreira; Dorita Bimbiryte; Djordje Miladinovic; Joachim M. Buhmann; Christian R. Baumann; Daniela Noain Introduction: Sleep insufficiency or decreased quality have been associated with Alzheimer’s disease (AD) already in its preclinical stages. Whether...

... 181 ) individually contribute to the identification of atypical phenotypes among a retrospective cohort of probable Alzheimer’s disease (AD) patients diagnosed by means of the ratio between Aβ 42 and Aβ 40 (Aβ 42/40 ). Methods: The retrospective study cohort comprised 50 probable AD patients diagnosed...

...Pagakrong Wanapaisan; Mallika Chuansangeam; Saifon Nopnipa; Rubwad Mathuranyanon; Nutthawan Nonthabenjawan; Chanon Ngamsombat; Tanyaluck Thientunyakit; Weerasak Muangpaisan Background: Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are common in older adults. Much recent work has...

...Xiao Hu; Toru Yamashita; Haibo Yu; Zhihong Bian; Xinran Hu; Tian Feng; Koh Tadokoro; Ryuta Morihara; Koji Abe Background: Alzheimer’s disease (AD) is the most frequent cause of dementia among the elderly. The accumulation of amyloid beta (Aβ) and its downstream pathological events such as oxidative...

... to in the content or advertisements. Behavioral disturbances in dementia Alzheimer’s disease Neuropsychiatric symptoms of dementia Hypersexuality Inappropriate sexual behaviors This study is based on a review of the literature. We searched the following major databases: PsycINFO, Embase, PubMed...

...Xinyuan Jiang; Qingdong Wu; Cuicui Zhang; Maobo Wang Background: Accumulating evidence suggests an implication of neuroinflammation in Alzheimer’s disease (AD) pathogenesis. Homoharringtonine (HHT) is an antitumor reagent with anti-inflammatory activity. This study investigates whether and how HHT...

... for patients’ prognosis. Emerging evidence shows fluid biomarkers are useful in diagnosis and pathophysiological research of iNPH. Methods: Probable iNPH and Alzheimer’s disease (AD) patients were recruited. Clinical diagnosis was performed according to international guidelines. CSF collection complied...

...Nira Cedres; Urban Ekman; Konstantinos Poulakis; Sara Shams; Lena Cavallin; Sebastian Muehlboeck; Tobias Granberg; Lars-Olof Wahlund; Daniel Ferreira; Eric Westman; Alzheimer’s Disease Neuroimaging Initiative Introduction: We investigated the association between atrophy subtypes of Alzheimer’s...

... nervous system during surgery, which is similar to that of Alzheimer’s disease (AD). Enriched environment (EE), a factor that can significantly improve and prevent neurodegenerative diseases, may have a beneficial effect on POCD. Key Messages: This review aims to elucidate the mechanism of the occurrence...

...Yong S. Shim; Hae-Eun Shin Objective: The electrocortical activities associated with the neuropsychiatric symptoms (NPSs) of Alzheimer’s disease (AD) were investigated using frequency-domain electroencephalography (EEG) spectral source analysis, and the potential electrocortical indices identified...

... milk. Exosomes can spread toxic amyloid-beta (Aβ) and hyperphosphorylated tau between cells, contributing to neuronal loss in Alzheimer’s disease (AD). Objective: To explore changes in the morphology, number, and pathological protein levels of urinary exosomes in AD patients compared with age-matched...

...Jan Klohs Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer’s disease (AD). It is believed to contribute additively to the cognitive impairment and to lower the threshold for the development of dementia. However, accumulating evidence suggests that dysfunction...

... and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer’s disease patients. Results: CSF-NEP was significantly inversely associated with CSF-Aβ 42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. Conclusions: Our results...