...Songzhe He; Shan Zhong; Gang Liu; Jun Yang Background: Parkinson’s disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However...

...Luxuan Wang; Guowei Wang; Yangyang Duan; Feng Wang; Shaoqing Lin; Fengting Zhang; Hui Li; Andy Li; Haining Li Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by intracellular α-synuclein (α-Syn) deposition. Alternation of the α-Syn expression level in plasma...

... composed of the fibrillogenic protein α-synuclein (α-syn). The familial-PD-related protein DJ-1 was reported to reduce dopaminergic degeneration triggered by α-syn or by the dopaminergic-selective neurotoxin 6-hydroxydopamine (6-OHDA). Objective: The aim was to further investigate the role of DJ-1...

...Dennis Selkoe; Ulf Dettmer; Eric Luth; Nora Kim; Andrew Newman; Tim Bartels Misfolding and pathogenic aggregation of α-synuclein (αSyn) is a hallmark of familial and sporadic Parkinson's disease, but the physiological state of the protein in cells remains unsettled. We have further examined our...

...Judith Eschbach; Karin M. Danzer Parkinson's disease is a common neurodegenerative disease characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of α-synuclein aggregates found in Lewy bodies throughout the brain. Several α-synuclein transgenic...

... regarding its potential mechanistic implications. Objective: The aim of this study was to review the relative importance of Lewy-related α-synuclein and Alzheimer's tau and amyloid-β (Aβ) pathologies in disease progression and dementia in PD. Methods: We reviewed studies conducted at the Queen Square Brain...

...András Szamosi; Helga Nagy; Szabolcs Kéri Background/Aims: α-Synuclein (SNCA) may be a key factor in dopaminergic neurotransmission, reward processing, and neurodegeneration in Parkinson’s disease (PD). We investigated delay discounting of reward and caudate volume in SNCA gene duplication carriers...

...S. Pablo Sardi; Priyanka Singh; Seng H. Cheng; Lamya S. Shihabuddin; Michael G. Schlossmacher Heterozygous mutations in the glucocerebrosidase gene (GBA1) are associated with increased risk for α-synuclein aggregation disorders (‘synucleinopathies’), which include Parkinson’s disease (PD...

... with diffuse staining of phosphorylated tau protein. In PD, increased immunoreactivity for UPR activation markers is detected in neuromelanin containing dopaminergic neurons of the substantia nigra, which colocalize with diffuse α-synuclein staining. Conclusion: UPR activation is closely associated...

...Emma L. Jones; Dag Aarsland; Elisabet Londos; Clive Ballard Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including α-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions...

.... Conclusions: Finally, we will endow a potential new therapeutic target for PD pathology. Mitochondria Tubulin Microtubules SIRT2 Autophagy α-Synuclein 7 06 2011 1 09 2011 9 12 2011 © 2011 S. Karger AG, Basel 2011 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... Research and Innovation) Dimebon Transgenic mouse model α-Synuclein Parkinson̓s disease Preclinical drug testing © 2011 S. Karger AG, Basel 2011 Open Access License / Drug Dosage / Disclaimer Open Access License: This is an Open Access article licensed under the terms of the Creative...

..., associated with the accumulation of aggregated α-synuclein (α-Syn) into proteinaceous inclusions named Lewy bodies. Various early forms of misfolded α-Syn oligomers are cytotoxic. Their formation is favored by mutations and external factors, such as heavy metals, pesticides, trauma-related oxidative stress...

... patients revealed the presence of caspase-cleaved TDP-43 in Lewy bodies and Hirano bodies in all cases examined. Colocalization of TDPccp with an antibody to α-synuclein (α-Syn), which served as a general marker for Lewy bodies, was evident within the substantia nigra in both α-synucleinopathies...

.... Parkinson’s disease Mitochondria Oxidative stress α-Synuclein Phosphorylation Diseases Treatment and Prevention Neurodegenerative Dis 2010;7:210 212 DOI: 10.1159/000295666 Published online: March 12, 2010 Future Strategies for Neuroprotection in Parkinson s Disease Anthony H.V. Schapira Department...

...M. Windisch; H. Wolf; B. Hutter-Paier; R. Wronski α-Synuclein (AS) is the main constituent of Lewy bodies. There is an ongoing discussion if overexpression is already dangerous, or if toxicity is subjected to oligomers, protofibrils or mature aggregates. The facts that the central hydrophobic part...

.... Aggregopathy Neurodegeneration Parkinson’s disease Neuroprotection Ubiquitin-proteasome system Therapeutic approaches α-Synuclein Diseases Review Neurodegenerative Dis 2008;5:321 338 DOI: 10.1159/000119459 Received: July 12, 2007 Accepted: July 16, 2007 Published online: February 29, 2008 Aggregopathy...

...Robin Barbour; Kristin Kling; John P. Anderson; Kelly Banducci; Tracy Cole; Linnea Diep; Michael Fox; Jason M. Goldstein; Ferdie Soriano; Peter Seubert; Tamie J. Chilcote Background: α-Synuclein has been directly linked to Parkinson’s disease etiology by mutations in and multiplication of its gene...

... to in the content or advertisements. Mouse Monkey α-Synuclein DJ-1 Substantia nigra Striatum Diseases Modeling Neurodegenerative Diseases in vivo Review Neurodegenerative Dis 2005;2:313 320 DOI: 10.1159/000092318 Received: February 27, 2006 Accepted: March 14, 2006 Animal Models of Parkinson s Disease...

...Lyutha Maskri; XinRan Zhu; Sabrina Fritzen; Kati Kühn; Christoph Ullmer; Peter Engels; Michael Andriske; Christine C. Stichel; Hermann Lübbert Two missense mutations (A53T and A30P) in the gene encoding the presynaptic protein α-synuclein (asyn) are associated with rare, dominantly inherited forms...