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Issues

Volume 5, Issue 3-4
March 2008
Neurodegenerative Diseases Cover Image for Volume 5, Issue 3-4
All Issues
ISSN 1660-2854
EISSN 1660-2862

Neurodegenerative Diseases 2008, Vol. 5, No. 3-4

Special Section

Title Page / Table of Contents
Neurodegener Dis (2008) 5 (3-4): 109–112. https://doi.org/10.1159/000120416
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Paper

Preface
Israel Hanin; Manfred Windisch; Werner Poewe; Abraham Fisher
Neurodegener Dis (2008) 5 (3-4): 113. https://doi.org/10.1159/000116115
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Keynote Address

Basic Research on Dopamine in Parkinson’s Disease and the Discovery of the Nigrostriatal Dopamine Pathway: The View of an Eyewitness
Oleh Hornykiewicz
Neurodegener Dis (2008) 5 (3-4): 114–117. https://doi.org/10.1159/000113678
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AD/PD – General Considerations

Neuropathological Aspects of Alzheimer Disease, Parkinson Disease and Frontotemporal Dementia
Kurt A. Jellinger
Neurodegener Dis (2008) 5 (3-4): 118–121. https://doi.org/10.1159/000113679
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Etiology and Pathophysiology of Frontotemporal Dementia, Parkinson Disease and Alzheimer Disease: Lessons from Genetic Studies
Christian Wider; Zbigniew K. Wszolek
Neurodegener Dis (2008) 5 (3-4): 122–125. https://doi.org/10.1159/000113680
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Pathophysiology of Neuronal Energy Crisis in Alzheimer’s Disease
Jack C. de la Torre
Neurodegener Dis (2008) 5 (3-4): 126–132. https://doi.org/10.1159/000113681
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Biomarkers for the Early Detection of Parkinson’s and Alzheimer’s Disease
Daniela Berg
Neurodegener Dis (2008) 5 (3-4): 133–136. https://doi.org/10.1159/000113682
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Early Detection of Parkinson’s Disease: Unmet Needs
Manfred Gerlach; Albrecht Hendrich; Roland Hueber; Wolfgang Jost; Jürgen Winkler; Dirk Woitalla; Peter Riederer
Neurodegener Dis (2008) 5 (3-4): 137–139. https://doi.org/10.1159/000113683
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Beta-Amyloid

Intraneuronal β-Amyloid Is a Major Risk Factor – Novel Evidence from the APP/PS1KI Mouse Model
Thomas A. Bayer; Henning Breyhan; Kailai Duan; Jens Rettig; Oliver Wirths
Neurodegener Dis (2008) 5 (3-4): 140–142. https://doi.org/10.1159/000113684
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Physiologic Origins of Age-Related β-Amyloid Deposition
Thomas G. Beach
Neurodegener Dis (2008) 5 (3-4): 143–145. https://doi.org/10.1159/000113685
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Impact of Intracellular β-Amyloid in Transgenic Animals and Cell Models
A. Claudio Cuello; Fabio Canneva
Neurodegener Dis (2008) 5 (3-4): 146–148. https://doi.org/10.1159/000113686
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β-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway
Margarita C. Dinamarca; Marcela Colombres; Waldo Cerpa; Christian Bonansco; Nibaldo C. Inestrosa
Neurodegener Dis (2008) 5 (3-4): 149–152. https://doi.org/10.1159/000113687
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Potent β-Amyloid Modulators
E. García-Palomero; P. Muñoz; P. Usan; P. Garcia; E. Delgado; C. De Austria; R. Valenzuela; L. Rubio; M. Medina; A. Martínez
Neurodegener Dis (2008) 5 (3-4): 153–156. https://doi.org/10.1159/000113688
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Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice
Anne Eckert; Susanne Hauptmann; Isabel Scherping; Virginie Rhein; Franz Müller-Spahn; Jürgen Götz; Walter E. Müller
Neurodegener Dis (2008) 5 (3-4): 157–159. https://doi.org/10.1159/000113689
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Processes of β-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/γ-Secretase
Shinji Tagami; Masayasu Okochi; Akio Fukumori; Jingwei Jiang; Kanta Yanagida; Taisuke Nakayama; Takashi Morihara; Toshihisa Tanaka; Takashi Kudo; Masatoshi Takeda
Neurodegener Dis (2008) 5 (3-4): 160–162. https://doi.org/10.1159/000113690
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Distinct Functional Effects of Human 5-HT4 Receptor Isoforms on β-Amyloid Secretion
Sylvain J. Robert; Frank Lezoualc’h
Neurodegener Dis (2008) 5 (3-4): 163–165. https://doi.org/10.1159/000113691
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Preamyloid

Activation of the Amyloid Cascade by Intracerebroventricular Injection of the Protease Inhibitor Phosphoramidon
Yotam Nisemblat; Haim Belinson; Iftach Dolev; Daniel M. Michaelson
Neurodegener Dis (2008) 5 (3-4): 166–169. https://doi.org/10.1159/000113692
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Mechanism of Glial Differentiation of Neural Progenitor Cells by Amyloid Precursor Protein
Kiminobu Sugaya
Neurodegener Dis (2008) 5 (3-4): 170–172. https://doi.org/10.1159/000113693
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Preamyloid Lesions and Cerebrovascular Deposits in the Mechanism of Dementia: Lessons from Non-β-Amyloid Cerebral Amyloidosis
Agueda Rostagno; Jorge Ghiso
Neurodegener Dis (2008) 5 (3-4): 173–175. https://doi.org/10.1159/000113694
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Genetics

Influence of Pharmacogenetic Factors on Alzheimer’s Disease Therapeutics
Ramón Cacabelos
Neurodegener Dis (2008) 5 (3-4): 176–178. https://doi.org/10.1159/000113695
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Functional Genomics Dissects Pathomechanisms in Tauopathies: Mitosis Failure and Unfolded Protein Response
Jürgen Götz; Della David; Frederic Hoerndli; Yazi D. Ke; Nicole Schonrock; Andreas Wiesner; Thomas Fath; Laita Bokhari; Yun-An Lim; Natasha Deters; Lars M. Ittner
Neurodegener Dis (2008) 5 (3-4): 179–181. https://doi.org/10.1159/000113696
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Investigating Convergent Actions of Genes Linked to Familial Parkinson’s Disease
Benjamin Wolozin; Shamol Saha; Maria Guillily; Andrew Ferree; Misha Riley
Neurodegener Dis (2008) 5 (3-4): 182–185. https://doi.org/10.1159/000113697
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Apolipoprotein E ε4 Allele Is Associated with Increased Atrophy in Progressive Mild Cognitive Impairment: A Voxel-Based Morphometric Study
A. Hämäläinen; M. Grau-Olivares; S. Tervo; E. Niskanen; C. Pennanen; J. Huuskonen; M. Kivipelto; T. Hänninen; M. Tapiola; M. Vanhanen; M. Hallikainen; E.-L. Helkala; A. Nissinen; R.L. Vanninen; H. Soininen
Neurodegener Dis (2008) 5 (3-4): 186–189. https://doi.org/10.1159/000113698
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Inflammation

Neuroinflammation in Plaque and Vascular β-Amyloid Disorders: Clinical and Therapeutic Implications
Piet Eikelenboom; Rob Veerhuis; Atoosa Familian; Jeroen J.M. Hoozemans; Willem A. van Gool; Annemieke J.M. Rozemuller
Neurodegener Dis (2008) 5 (3-4): 190–193. https://doi.org/10.1159/000113699
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Progress in the Active Immunotherapeutic Approach to Alzheimer’s Disease: Clinical Investigations into AN1792-Associated Meningoencephalitis
Michael Pride; Peter Seubert; Michael Grundman; Michael Hagen; John Eldridge; Ronald S. Black
Neurodegener Dis (2008) 5 (3-4): 194–196. https://doi.org/10.1159/000113700
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Glycosaminoglycans (GAGs)

Engineered Heparins: Novel β-Secretase Inhibitors as Potential Alzheimer’s Disease Therapeutics
S.J. Patey; E.A. Edwards; E.A. Yates; J.E. Turnbull
Neurodegener Dis (2008) 5 (3-4): 197–199. https://doi.org/10.1159/000113701
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Neuroprotective Properties of Glycosaminoglycans: Potential Treatment for Neurodegenerative Disorders
B. Dudas; M. Rose; U. Cornelli; A. Pavlovich; I. Hanin
Neurodegener Dis (2008) 5 (3-4): 200–205. https://doi.org/10.1159/000113702
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Regulation of proBACE1 by Glycosaminoglycans
David H. Small; David W. Klaver; Marie Beckman
Neurodegener Dis (2008) 5 (3-4): 206–208. https://doi.org/10.1159/000113703
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Various Markers

Conformationally Altered p53: A Putative Peripheral Marker for Alzheimer’s Disease
Daniela Uberti; Cristina Lanni; Marco Racchi; Stefano Govoni; Maurizio Memo
Neurodegener Dis (2008) 5 (3-4): 209–211. https://doi.org/10.1159/000113704
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ACAT as a Drug Target for Alzheimer’s Disease
Henri J. Huttunen; Dora M. Kovacs
Neurodegener Dis (2008) 5 (3-4): 212–214. https://doi.org/10.1159/000113705
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In vivo and Postmortem Clinicoanatomical Correlations in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17
Bernardino Ghetti; Salvatore Spina; Jill R. Murrell; Edward D. Huey; Pietro Pietrini; Brian Sweeney; Eric M. Wassermann; Catherine Keohane; Martin R. Farlow; Jordan Grafman
Neurodegener Dis (2008) 5 (3-4): 215–217. https://doi.org/10.1159/000113706
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Alpha-Synuclein

The Role of Alpha-Synuclein in Neurodegenerative Diseases: A Potential Target for New Treatment Strategies?
M. Windisch; H. Wolf; B. Hutter-Paier; R. Wronski
Neurodegener Dis (2008) 5 (3-4): 218–221. https://doi.org/10.1159/000113707
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Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies
George Perry; Xiongwei Zhu; Asim K. Babar; Sandra L. Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; Shu G. Chen
Neurodegener Dis (2008) 5 (3-4): 222–224. https://doi.org/10.1159/000113708
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Cholinergic Aspects

Polymorphisms at the Paraoxonase 1 L55M and Q192R Loci Affect the Pathophysiology of Alzheimer’s Disease: Emphasis on the Cholinergic System and Beta-Amyloid Levels
Valerie Leduc; Judes Poirier
Neurodegener Dis (2008) 5 (3-4): 225–227. https://doi.org/10.1159/000113709
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Galanin Hyperinnervation Upregulates Choline Acetyltransferase Expression in Cholinergic Basal Forebrain Neurons in Alzheimer’s Disease
Scott E. Counts; Bin He; Shaoli Che; Stephen D. Ginsberg; Elliott J. Mufson
Neurodegener Dis (2008) 5 (3-4): 228–231. https://doi.org/10.1159/000113710
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Human Recombinant Butyrylcholinesterase Purified from the Milk of Transgenic Goats Interacts with Beta-Amyloid Fibrils and Suppresses Their Formation in vitro
E. Podoly; T. Bruck; S. Diamant; N. Melamed-Book; A. Weiss; Y. Huang; O. Livnah; S. Langermann; H. Wilgus; H. Soreq
Neurodegener Dis (2008) 5 (3-4): 232–236. https://doi.org/10.1159/000113711
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M1 Muscarinic Agonists Target Major Hallmarks of Alzheimer’s Disease – The Pivotal Role of Brain M1 Receptors
Abraham Fisher
Neurodegener Dis (2008) 5 (3-4): 237–240. https://doi.org/10.1159/000113712
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Other, Miscellaneous

Glutamatergic Approaches to the Treatment of Cognitive and Behavioural Symptoms of Alzheimer’s Disease
Paul T. Francis
Neurodegener Dis (2008) 5 (3-4): 241–243. https://doi.org/10.1159/000113713
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Duodenal Levodopa Infusion Improves Quality of Life in Advanced Parkinson’s Disease
A. Antonini; F. Mancini; M. Canesi; R. Zangaglia; I.U. Isaias; L. Manfredi; C. Pacchetti; M. Zibetti; F. Natuzzi; L. Lopiano; G. Nappi; G. Pezzoli
Neurodegener Dis (2008) 5 (3-4): 244–246. https://doi.org/10.1159/000113714
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Lithium, a Potential Protective Drug in Alzheimer’s Disease
T. Engel; P. Goñi-Oliver; E. Gómez de Barreda; J.J. Lucas; F. Hernández; J. Avila
Neurodegener Dis (2008) 5 (3-4): 247–249. https://doi.org/10.1159/000113715
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Seeding Neuritic Plaques from the Distance: A Possible Role for Brainstem Neurons in the Development of Alzheimer’s Disease Pathology
Zoia Muresan; Virgil Muresan
Neurodegener Dis (2008) 5 (3-4): 250–253. https://doi.org/10.1159/000113716
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Aging

Effects of Aging on Neuroprotective and Neurotoxic Properties of Microglia in Neurodegenerative Diseases
Makoto Sawada; Hirohide Sawada; Toshiharu Nagatsu
Neurodegener Dis (2008) 5 (3-4): 254–256. https://doi.org/10.1159/000113717
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The Long-Term Effects of Oophorectomy on Cognitive and Motor Aging Are Age Dependent
Walter A. Rocca; Brandon R. Grossardt; Demetrius M. Maraganore
Neurodegener Dis (2008) 5 (3-4): 257–260. https://doi.org/10.1159/000113718
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Assessing Change in Cognitive Function in Dementia: The Relative Utilities of the Alzheimer’s Disease Assessment Scale – Cognitive Subscale and the Cognitive Drug Research System
Keith A. Wesnes
Neurodegener Dis (2008) 5 (3-4): 261–263. https://doi.org/10.1159/000113719
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Further Section

Author Index Vol. 5, No. 3–4, 2008
Neurodegener Dis (2008) 5 (3-4): 264. https://doi.org/10.1159/000120417
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Subject Index Vol. 5, No. 3–4, 2008
Neurodegener Dis (2008) 5 (3-4): 265–266. https://doi.org/10.1159/000120418
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Sclerostin: A Potential Link between Osteoporosis and Alzheimer's Disease
How many steps to reach steady state of postural stability, progression velocity and step length during gait initiation? Effects of ageing and Parkinson’s disease
Risk of developing Alzheimer disease in relation to common infections
Sex Differences in Biofluid Biomarkers for Alzheimer’s Disease
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