Abstract
Background: Parkinson’s disease (PD) is one of the most common neurological disorders that mostly affect aged individuals. The common symptoms of PD are rest tremor, bradykinesia, and rigidity. Objectives: The present study was devised to find out the clinical features and risk factors associated with PD in a population of Khyber Pakhtunkhwa. Methods:A total of 600 PD patients and 1,200 control individuals took part in this study. The participants filled out a standard questionnaire. Results: This study found a significant association between PD and exposure to pesticides (p < 0.0001) and doing work on farms (p < 0.0001). The use of aldrin was significantly associated with PD (p < 0.0001). Furthermore, we also found that PD status was associated with individuals who have a history of depression, hypertension, head injury, and Alzheimer’s disease. This study also showed that the PD rate was lower in those who were using tobacco products. Conclusion: In this case-control study, we revealed some environmental and medical conditions that are linked with PD. To control the disease, we must minimize exposure to pesticides, and the government and scientific community should play their role.
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References
1.
Dorsey
ER
, Constantinescu
R
, Thompson
JP
, Biglan
KM
, Holloway
RG
, Kieburtz
K
, et al.. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
. Neurology
. 2007
Jan
;68
(5
):384
–6
.
[PubMed]
0028-38782.
Jankovic
J
. Parkinson’s disease: clinical features and diagnosis
. J Neurol Neurosurg Psychiatry
. 2008
Apr
;79
(4
):368
–76
.
[PubMed]
0022-30503.
Gibb
WR
, Lees
AJ
. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson’s disease
. J Neurol Neurosurg Psychiatry
. 1991
May
;54
(5
):388
–96
.
[PubMed]
0022-30504.
Ahmed
H
, Abushouk
AI
, Gabr
M
, Negida
A
, Abdel-Daim
MM
. Parkinson’s disease and pesticides: A meta-analysis of disease connection and genetic alterations
. Biomed Pharmacother
. 2017
Jun
;90
:638
–49
.
[PubMed]
0753-33225.
Bellou
V
, Belbasis
L
, Tzoulaki
I
, Evangelou
E
, Ioannidis
JP
. Environmental risk factors and Parkinson’s disease: an umbrella review of meta-analyses
. Parkinsonism Relat Disord
. 2016
Feb
;23
:1
–9
.
[PubMed]
1353-80206.
Zorzon
M
, Capus
L
, Pellegrino
A
, Cazzato
G
, Zivadinov
R
. Familial and environmental risk factors in Parkinson’s disease: a case-control study in north-east Italy
. Acta Neurol Scand
. 2002
Feb
;105
(2
):77
–82
.
[PubMed]
0001-63147.
Wright
JM
, Keller-Byrne
J
. Environmental determinants of Parkinson’s disease
. Arch Environ Occup Health
. 2005
Jan-Feb
;60
(1
):32
–8
.
[PubMed]
1933-82448.
Fall
PA
, Fredrikson
M
, Axelson
O
, Granérus
AK
. Nutritional and occupational factors influencing the risk of Parkinson’s disease: a case-control study in southeastern Sweden
. Mov Disord
. 1999
Jan
;14
(1
):28
–37
.
[PubMed]
0885-31859.
Baltazar
MT
, Dinis-Oliveira
RJ
, de Lourdes Bastos
M
, Tsatsakis
AM
, Duarte
JA
, Carvalho
F
. Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases—a mechanistic approach
. Toxicol Lett
. 2014
Oct
;230
(2
):85
–103
.
[PubMed]
0378-427410.
Claus
PJ
, Diamond
S
, Mills
MA
. South Asian Folklore: An Encyclopedia
. Afghanistan, Bangladesh, India, Nepal, Pakistan, Sri Lanka
: Taylor & Francis
; 2003
.11.
Statistics PBo. Provisional Summary Results of 6th Population and Housing Census–2017.
2017
.12.
Pakistan LEi. Life Expectancy in Pakistan.
2019
.13.
Chaudhry
M.
. Pakistan: where and who are the world’s illiterates?
Background paper prepared for the Education For All Global Monitoring Report 2006; Literacy for life. 2005
.14.
Hughes
AJ
, Daniel
SE
, Kilford
L
, Lees
AJ
. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases
. J Neurol Neurosurg Psychiatry
. 1992
Mar
;55
(3
):181
–4
.
[PubMed]
0022-305015.
Spss
I
. IBM SPSS statistics for Windows, version 20.0
. New York
: IBM Corp.
; 2011
. p. 440
.16.
Tarakad
A
, Jankovic
J
. Diagnosis and management of Parkinson’s disease. Seminars in neurology
. Thieme Medical Publishers
; 2017
. pp. 118
–26
.17.
Hatcher
JM
, Pennell
KD
, Miller
GW
. Parkinson’s disease and pesticides: a toxicological perspective
. Trends Pharmacol Sci
. 2008
Jun
;29
(6
):322
–9
.
[PubMed]
0165-614718.
Narayan
S
, Liew
Z
, Bronstein
JM
, Ritz
B
. Occupational pesticide use and Parkinson’s disease in the Parkinson Environment Gene (PEG) study
. Environ Int
. 2017
Oct
;107
:266
–73
.
[PubMed]
0160-412019.
Chhillar
N
, Singh
NK
, Banerjee
B
, Bala
K
, Mustafa
M
, Sharma
D
, et al.. Organochlorine pesticide levels and risk of Parkinson’s disease in north Indian population.
ISRN neurology. 2013
;2013. 20.
Hatcher
JM
, Delea
KC
, Richardson
JR
, Pennell
KD
, Miller
GW
. Disruption of dopamine transport by DDT and its metabolites
. Neurotoxicology
. 2008
Jul
;29
(4
):682
–90
.
[PubMed]
0161-813X21.
Stykel
MG
, Humphries
K
, Kirby
MP
, Czaniecki
C
, Wang
T
, Ryan
T
, et al.. Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson’s disease
. FASEB J
. 2018
Oct
;32
(10
):5350
–64
.
[PubMed]
0892-663822.
Carelli
L
, Solca
F
, Torre
S
, Pasquini
J
, Morelli
C
, Pezzati
R
, et al.. A novel approach for investigating Parkinson’s Disease personality and its association with clinical and psychological aspects
. Front Psychol
. 2019
Oct
;10
:2265
.
[PubMed]
1664-107823.
Chen
J
, Zhang
C
, Wu
Y
, Zhang
D
. Association between Hypertension and the Risk of Parkinson’s Disease: A Meta-Analysis of Analytical Studies
. Neuroepidemiology
. 2019
;52
(3-4
):181
–92
.
[PubMed]
0251-535024.
Wang
S
, Mao
S
, Xiang
D
, Fang
C
. Association between depression and the subsequent risk of Parkinson’s disease: A meta-analysis
. Prog Neuropsychopharmacol Biol Psychiatry
. 2018
Aug
;86
:186
–92
.
[PubMed]
0278-584625.
Nicoletti
A
, Vasta
R
, Mostile
G
, Nicoletti
G
, Arabia
G
, Iliceto
G
, et al.. Head trauma and Parkinson’s disease: results from an Italian case-control study
. Neurol Sci
. 2017
Oct
;38
(10
):1835
–9
.
[PubMed]
1590-187426.
Georgiou
A
, Demetriou
CA
, Christou
YP
, Heraclides
A
, Leonidou
E
, Loukaides
P
, et al.. Genetic and environmental factors contributing to Parkinson’s disease: a case-control study in the Cypriot population
. Front Neurol
. 2019
Oct
;10
:1047
.
[PubMed]
1664-2295© 2020 S. Karger AG, Basel
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