Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.

1.
Tohill M, Terenghi G: Stem-cell plasticity and therapy for injuries of the peripheral nervous system. Biotechnol Appl Biochem 2004;40:17-24.
2.
Zuk PA, Zhu M, Ashjian P, et al: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295.
3.
Grewal NS, Gabbay JS, Ashley RK, Wasson KL, Bradley JP, Zuk PA: BMP-2 does not influence the osteogenic fate of human adipose-derived stem cells. Plast Reconstr Surg 2009;123:158S-165S.
4.
Tomita K, Madura T, Sakai Y, Yano K, Terenghi G, Hosokawa K: Glial differentiation of human adipose-derived stem cells: implications for cell-based transplantation therapy. Neuroscience 2013;236:55-65.
5.
Ra JC, Shin IS, Kim SH, et al: Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev 2011;20:1297-1308.
6.
Lee ST, Chu K, Jung KH, et al: Slowed progression in models of Huntington disease by adipose stem cell transplantation. Ann Neurol 2009;66:671-681.
7.
Bhang SH, Cho SW, Lim JM, et al: Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells 2009;27:1976-1986.
8.
Im W, Ban J, Lim J, et al: Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease. PLoS One 2013;8:e59438.
9.
Kim S, Chang KA, Kim J, et al: The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. PLoS One 2012;7:e45757.
10.
Lin MN, Shang DS, Sun W, et al: Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers. Brain Res 2013;1513:1-8.
11.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, et al: Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA 2009;106:13594-13599.
12.
Lee HJ, Lee JK, Lee H, et al: The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease. Neurosci Lett 2010;481:30-35.
13.
Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS: Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells 2010;28:329-343.
14.
Katsuda T, Tsuchiya R, Kosaka N, et al: Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep 2013;3:1197.
15.
Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM: Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci 2007;27:11925-11933.
16.
Martino G, Pluchino S: The therapeutic potential of neural stem cells. Nat Rev Neurosci 2006;7:395-406.
17.
Bao X, Wei J, Feng M, et al: Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res 2011;1367:103-113.
18.
Liu N, Chen R, Du H, Wang J, Zhang Y, Wen J: Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells. Cell Mol Immunol 2009;6:207-213.
19.
Mathieu P, Battista D, Depino A, Roca V, Graciarena M, Pitossi F: The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain. J Neurochem 2010;112:1368-1385.
20.
Carpentier PA, Palmer TD: Immune influence on adult neural stem cell regulation and function. Neuron 2009;64:79-92.
21.
Ruiz de Almodovar C, Lambrechts D, Mazzone M, Carmeliet P: Role and therapeutic potential of VEGF in the nervous system. Physiol Rev 2009;89:607-648.
22.
Kalbermatten DF, Schaakxs D, Kingham PJ, Wiberg M: Neurotrophic activity of human adipose stem cells isolated from deep and superficial layers of abdominal fat. Cell Tissue Res 2011;344:251-260.
23.
Rehman J, Traktuev D, Li J, et al: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-1298.
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