Abstract
Objective: The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (DRD2) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels. Methods: One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of DRD2 polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing. Results: In DRD2 gene C957T (rs6277), three genotypes of CC, CT, and TT were detected with the frequencies of 92.67%, 6.67%, 0.67% in dyslipidemia cases, and 83.33%, 14.67%, 2.00% in the controls, respectively. The CT genotype and T allele frequencies were significantly low in the case group relative to the control group. After adjusting to other clinical indicators, the CT genotype of C957T polymorphism (hazard ratio = 0.401, 95% confidence interval = 0.181–0.890, p < 0.05) was still related to a significantly reduced risk of dyslipidemia. The C957T CT genotype carriers had the lowest values of serum TC, TG, LDL, and the highest values of serum HDL-C. Conclusion:DRD2 gene C957T polymorphism was an independent influencing factor associated with the susceptibility to dyslipidemia, and the CT genotype was associated with decreased odds of susceptibility to dyslipidemia.
Journal Section:
Original Article
References
1.
Cao DL, Zhang XJ, Xie SQ, Fan SJ, Qu XJ. Application of chloroplast genome in the identification of Traditional Chinese Medicine Viola philippica. BMC Genomics. 2022;23(1):540.
2.
Cardel MI, Lemas DJ, Lee AM, Miller DR, Huo T, Klimentidis YC, et al. Taq1a polymorphism (rs1800497) is associated with obesity-related outcomes and dietary intake in a multi-ethnic sample of children. Pediatr Obes. 2019;14(2):e12470.
3.
Crum-Cianflone N, Tejidor R, Medina S, Barahona I, Ganesan A. Obesity among patients with HIV: the latest epidemic. AIDS Patient Care STDS. 2008;22(12):925–30.
4.
Guo S, Yang J, Jiang B, Zhou N, Ding H, Zhou G, et al. MicroRNA editing patterns in Huntington’s disease. Sci Rep. 2022;12(1):3173.
5.
He H, Yu YQ, Li Y, Kou CG, Li B, Tao YC, et al. Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study. Lipids Health Dis. 2014;13:122.
6.
Hu Y, Sui Z, Zhou W, Wang J, Jiang M, Chen H, et al. Heterozygous single nucleotide polymorphic loci in haploid gametophytes of gracilariopsis lemaneiformis (rhodophyta). Front Genet. 2019;10:1256.
7.
Klein MO, Battagello DS, Cardoso AR, Hauser DN, Bittencourt JC, Correa RG. Dopamine: functions, signaling, and association with neurological diseases. Cell Mol Neurobiol. 2019;39(1):31–59.
8.
Li W, Zhang H, Zhang L, Zhang T, Ding H. Effect of thymoquinone on renal damage induced by hyperlipidemia in LDL receptor-deficient (LDL-R [−]/[−]) mice. Biomed Res Int. 2022;2022:7709926.
9.
Lucchi T. Dyslipidemia and prevention of atherosclerotic cardiovascular disease in the elderly. Minerva Med. 2021;112(6):804–16.
10.
Luo Z, Li S, Muhammad I, Karim MR, Song Y. Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis. Lipids Health Dis. 2018;17(1):274.
11.
Ma ZS, Li L, Zhang YP. Defining individual-level genetic diversity and similarity profiles. Sci Rep. 2020;10(1):5805.
12.
Martel JC, Gatti McArthur S. Dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia. Front Pharmacol. 2020;11:1003.
13.
Matey-Hernandez ML, Williams FMK, Potter T, Valdes AM, Spector TD, Menni C. Genetic and microbiome influence on lipid metabolism and dyslipidemia. Physiol Genomics. 2018;50(2):117–26.
14.
Ming J, Wei X, Han M, Adi D, Abuzhalihan J, Wang YT, et al. Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China. Sci Rep. 2021;11(1):5969.
15.
Nagar N, Nagar S, Bharadva N, Patel HB, Mahyavanshi D, Nagar SS. Study on prevalence of obesity using different scales and its association with hypertension among the elderly in a district of Gujarat. J Family Med Prim Care. 2022;11(1):162–9.
16.
Neuman J, Roeder N, Richardson B, Quattrin T, Hamilton J, Thanos PK. High fat diet increases ([3]H) flunitrazepam binding in the mouse brain that is dependent on the expression of the dopamine D2 gene. Neurochem Res. 2022;47(10):3003–11.
17.
Niewczas M, Grzywacz A, Leźnicka K, Chmielowiec K, Chmielowiec J, Maciejewska-Skrendo A, et al. Association between polymorphism rs1799732 of DRD2 dopamine receptor gene and personality traits among MMA athletes. Genes. 2021;12(8):1217.
18.
Pak K, Seok JW, Lee MJ, Kim K, Kim IJ. Dopamine receptor and dopamine transporter in obesity: a meta-analysis. Synapse. 2023;77(1):e22254.
19.
Ramos-Lopez O, Panduro A, Rivera-Iniguez I, Roman S. Dopamine D2 receptor polymorphism (C957T) is associated with sugar consumption and triglyceride levels in West Mexicans. Physiol Behav. 2018;194:532–7.
20.
Sandesara PB, Virani SS, Fazio S, Shapiro MD. The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk. Endocr Rev. 2019;40(2):537–57.
21.
Srinivasan R, Padmapriyadarsini C, Ramesh K, Sanjeeva GN, Reddy D, Suresh E, et al. APOC3 gene polymorphism and antiretroviral therapy-induced dyslipidemia in HIV-infected children. AIDS Res Hum Retroviruses. 2021;37(2):92–100.
22.
Szlaga A, Sambak P, Gugula A, Trenk A, Gundlach AL, Blasiak A. Catecholaminergic innervation and D2-like dopamine receptor-mediated modulation of brainstem nucleus incertus neurons in the rat. Neuropharmacology. 2022;218:109216.
23.
Volkow ND, Wang GJ, Baler RD. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci. 2011;15(1):37–46.
24.
writing committee of the report on cardiovascular h, diseases in c. Report on cardiovascular health and diseases in China 2021: an updated summary. Biomed Environ Sci. 2022;35(7):573–603.
25.
Xu H, Kellendonk CB, Simpson EH, Keilp JG, Bruder GE, Polan HJ, et al. DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability. Schizophr Res. 2007;90(1–3):104–7.
26.
Yu L, Zhu Q, Li Y, Song P, Zhang J. Dietary branched-chain amino acids (BCAAs) and risk of dyslipidemia in a Chinese population. Nutrients. 2022;14(9):1824.
27.
Zhang L, Hu L, Li X, Zhang J, Chen B. The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis. J Affect Disord. 2014;158:71–7.
28.
Zhu JF, Chen LH, Yuan K, Liang L, Wang CL. Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents. J Zhejiang Univ Sci B. 2018;19(10):807–14.
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