Objective: The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (DRD2) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels. Methods: One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of DRD2 polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing. Results: In DRD2 gene C957T (rs6277), three genotypes of CC, CT, and TT were detected with the frequencies of 92.67%, 6.67%, 0.67% in dyslipidemia cases, and 83.33%, 14.67%, 2.00% in the controls, respectively. The CT genotype and T allele frequencies were significantly low in the case group relative to the control group. After adjusting to other clinical indicators, the CT genotype of C957T polymorphism (hazard ratio = 0.401, 95% confidence interval = 0.181–0.890, p < 0.05) was still related to a significantly reduced risk of dyslipidemia. The C957T CT genotype carriers had the lowest values of serum TC, TG, LDL, and the highest values of serum HDL-C. Conclusion:DRD2 gene C957T polymorphism was an independent influencing factor associated with the susceptibility to dyslipidemia, and the CT genotype was associated with decreased odds of susceptibility to dyslipidemia.

1.
Cao
DL
,
Zhang
XJ
,
Xie
SQ
,
Fan
SJ
,
Qu
XJ
.
Application of chloroplast genome in the identification of Traditional Chinese Medicine Viola philippica
.
BMC Genomics
.
2022
;
23
(
1
):
540
.
2.
Cardel
MI
,
Lemas
DJ
,
Lee
AM
,
Miller
DR
,
Huo
T
,
Klimentidis
YC
.
Taq1a polymorphism (rs1800497) is associated with obesity-related outcomes and dietary intake in a multi-ethnic sample of children
.
Pediatr Obes
.
2019
;
14
(
2
):
e12470
.
3.
Crum-Cianflone
N
,
Tejidor
R
,
Medina
S
,
Barahona
I
,
Ganesan
A
.
Obesity among patients with HIV: the latest epidemic
.
AIDS Patient Care STDS
.
2008
;
22
(
12
):
925
30
.
4.
Guo
S
,
Yang
J
,
Jiang
B
,
Zhou
N
,
Ding
H
,
Zhou
G
.
MicroRNA editing patterns in Huntington’s disease
.
Sci Rep
.
2022
;
12
(
1
):
3173
.
5.
He
H
,
Yu
YQ
,
Li
Y
,
Kou
CG
,
Li
B
,
Tao
YC
.
Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study
.
Lipids Health Dis
.
2014
;
13
:
122
.
6.
Hu
Y
,
Sui
Z
,
Zhou
W
,
Wang
J
,
Jiang
M
,
Chen
H
.
Heterozygous single nucleotide polymorphic loci in haploid gametophytes of gracilariopsis lemaneiformis (rhodophyta)
.
Front Genet
.
2019
;
10
:
1256
.
7.
Klein
MO
,
Battagello
DS
,
Cardoso
AR
,
Hauser
DN
,
Bittencourt
JC
,
Correa
RG
.
Dopamine: functions, signaling, and association with neurological diseases
.
Cell Mol Neurobiol
.
2019
;
39
(
1
):
31
59
.
8.
Li
W
,
Zhang
H
,
Zhang
L
,
Zhang
T
,
Ding
H
.
Effect of thymoquinone on renal damage induced by hyperlipidemia in LDL receptor-deficient (LDL-R [−]/[−]) mice
.
Biomed Res Int
.
2022
;
2022
:
7709926
.
9.
Lucchi
T
.
Dyslipidemia and prevention of atherosclerotic cardiovascular disease in the elderly
.
Minerva Med
.
2021
;
112
(
6
):
804
16
.
10.
Luo
Z
,
Li
S
,
Muhammad
I
,
Karim
MR
,
Song
Y
.
Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis
.
Lipids Health Dis
.
2018
;
17
(
1
):
274
.
11.
Ma
ZS
,
Li
L
,
Zhang
YP
.
Defining individual-level genetic diversity and similarity profiles
.
Sci Rep
.
2020
;
10
(
1
):
5805
.
12.
Martel
JC
,
Gatti McArthur
S
.
Dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia
.
Front Pharmacol
.
2020
;
11
:
1003
.
13.
Matey-Hernandez
ML
,
Williams
FMK
,
Potter
T
,
Valdes
AM
,
Spector
TD
,
Menni
C
.
Genetic and microbiome influence on lipid metabolism and dyslipidemia
.
Physiol Genomics
.
2018
;
50
(
2
):
117
26
.
14.
Ming
J
,
Wei
X
,
Han
M
,
Adi
D
,
Abuzhalihan
J
,
Wang
YT
.
Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
.
Sci Rep
.
2021
;
11
(
1
):
5969
.
15.
Nagar
N
,
Nagar
S
,
Bharadva
N
,
Patel
HB
,
Mahyavanshi
D
,
Nagar
SS
.
Study on prevalence of obesity using different scales and its association with hypertension among the elderly in a district of Gujarat
.
J Family Med Prim Care
.
2022
;
11
(
1
):
162
9
.
16.
Neuman
J
,
Roeder
N
,
Richardson
B
,
Quattrin
T
,
Hamilton
J
,
Thanos
PK
.
High fat diet increases ([3]H) flunitrazepam binding in the mouse brain that is dependent on the expression of the dopamine D2 gene
.
Neurochem Res
.
2022
;
47
(
10
):
3003
11
.
17.
Niewczas
M
,
Grzywacz
A
,
Leźnicka
K
,
Chmielowiec
K
,
Chmielowiec
J
,
Maciejewska-Skrendo
A
.
Association between polymorphism rs1799732 of DRD2 dopamine receptor gene and personality traits among MMA athletes
.
Genes
.
2021
;
12
(
8
):
1217
.
18.
Pak
K
,
Seok
JW
,
Lee
MJ
,
Kim
K
,
Kim
IJ
.
Dopamine receptor and dopamine transporter in obesity: a meta-analysis
.
Synapse
.
2023
;
77
(
1
):
e22254
.
19.
Ramos-Lopez
O
,
Panduro
A
,
Rivera-Iniguez
I
,
Roman
S
.
Dopamine D2 receptor polymorphism (C957T) is associated with sugar consumption and triglyceride levels in West Mexicans
.
Physiol Behav
.
2018
;
194
:
532
7
.
20.
Sandesara
PB
,
Virani
SS
,
Fazio
S
,
Shapiro
MD
.
The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk
.
Endocr Rev
.
2019
;
40
(
2
):
537
57
.
21.
Srinivasan
R
,
Padmapriyadarsini
C
,
Ramesh
K
,
Sanjeeva
GN
,
Reddy
D
,
Suresh
E
.
APOC3 gene polymorphism and antiretroviral therapy-induced dyslipidemia in HIV-infected children
.
AIDS Res Hum Retroviruses
.
2021
;
37
(
2
):
92
100
.
22.
Szlaga
A
,
Sambak
P
,
Gugula
A
,
Trenk
A
,
Gundlach
AL
,
Blasiak
A
.
Catecholaminergic innervation and D2-like dopamine receptor-mediated modulation of brainstem nucleus incertus neurons in the rat
.
Neuropharmacology
.
2022
;
218
:
109216
.
23.
Volkow
ND
,
Wang
GJ
,
Baler
RD
.
Reward, dopamine and the control of food intake: implications for obesity
.
Trends Cogn Sci
.
2011
;
15
(
1
):
37
46
.
24.
writing committee of the report on cardiovascular h, diseases in c
.
Report on cardiovascular health and diseases in China 2021: an updated summary
.
Biomed Environ Sci
.
2022
;
35
(
7
):
573
603
.
25.
Xu
H
,
Kellendonk
CB
,
Simpson
EH
,
Keilp
JG
,
Bruder
GE
,
Polan
HJ
.
DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability
.
Schizophr Res
.
2007
90
1–3
104
7
.
26.
Yu
L
,
Zhu
Q
,
Li
Y
,
Song
P
,
Zhang
J
.
Dietary branched-chain amino acids (BCAAs) and risk of dyslipidemia in a Chinese population
.
Nutrients
.
2022
;
14
(
9
):
1824
.
27.
Zhang
L
,
Hu
L
,
Li
X
,
Zhang
J
,
Chen
B
.
The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis
.
J Affect Disord
.
2014
;
158
:
71
7
.
28.
Zhu
JF
,
Chen
LH
,
Yuan
K
,
Liang
L
,
Wang
CL
.
Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
.
J Zhejiang Univ Sci B
.
2018
;
19
(
10
):
807
14
.
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