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Medical Principles and Practice 2023, Vol. 32, No. 3

Review

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 155–165. https://doi.org/10.1159/000531422
Highlights of the Study

  • The number of patients with Parkinson’s disease is increasing worldwide.

  • Current treatments do not stop disease progress.

  • Preclinical studies pave the way to new treatments.

  • Clinical treatments under development include synolytics, gene editing, cell transplantation, targeted physiotherapy.

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 166–177. https://doi.org/10.1159/000531373
Highlights of the Study

  • COVID-19 oral sequelae are symptomatically characterized, and their pathogenic mechanisms are speculated.

  • Gustatory and saliva secretory dysfunctions persist in up to 45% of COVID-19 survivors at follow-ups of 3 weeks to 12 months.

  • Persistent ageusia/dysgeusia and xerostomia/dry mouth are pathogenically related to SARS-CoV-2 receptors expressed in the tongue and salivary glands and to SARS-CoV-2 infection-induced zinc deficiency.

Systematic Review

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 178–191. https://doi.org/10.1159/000531246
Highlights

  • This meta-analysis focuses on therapeutic responses, survival effects, and toxicity of Actinium-225 prostate-specific membrane antigen (Ac-225 PSMA) radioligand therapy in metastatic castration-resistant prostate cancer patients.

  • Patients enrolled in the studies underwent various local and systemic therapies before receiving 225Ac-PSMA.

Original Paper

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 192–199. https://doi.org/10.1159/000533284
Highlights

  • The variable clinical course of chronic lymphocytic leukemia and the lack of consensus on follow-up and treatment strategies have necessitated a prognostic model for identifying high-risk patients at the time of diagnosis.

  • We evaluated the applicability of these for Chronic Lymphocytic Leukemia International Prognostic Index in our young, Middle Eastern cohort (median age 59 years at diagnosis).

  • Chronic Lymphocytic Leukemia International Prognostic Index discriminates over time to the first treatment.

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 200–208. https://doi.org/10.1159/000529863
Highlights of the Study

  • This study found a two-fold higher risk of major bleeding in women, as compared to men, in subjects with acute coronary syndrome undergoing percutaneous coronary intervention and treated with dual antiplatelet therapy.

  • This sex difference was caused mainly by an excess femoral access site bleeds in women.

  • No differences in the incidence of ischemic events between women and men were found.

Subject Area: General Medicine
Med Princ Pract (2023) 32 (3): 209–216. https://doi.org/10.1159/000531413
Highlights of the Study

  • The presence of the dimple of Venus on physical examination is associated with increased pelvic incidence angle and more sagittally oriented facet joint angle.

  • These radiological anatomical findings may be a compensation for muscle deficiency in the nature of the dimples.

  • These findings may help physicians to reduce the need for serial radiological examinations in the evaluation of spinopelvic anatomy.

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