Medical Principles and Practice 2023, Vol. 32, No. 3
The number of patients with Parkinson’s disease is increasing worldwide.
Current treatments do not stop disease progress.
Preclinical studies pave the way to new treatments.
Clinical treatments under development include synolytics, gene editing, cell transplantation, targeted physiotherapy.
COVID-19 Oral Sequelae: Persistent Gustatory and Saliva Secretory Dysfunctions after Recovery from COVID-19
COVID-19 oral sequelae are symptomatically characterized, and their pathogenic mechanisms are speculated.
Gustatory and saliva secretory dysfunctions persist in up to 45% of COVID-19 survivors at follow-ups of 3 weeks to 12 months.
Persistent ageusia/dysgeusia and xerostomia/dry mouth are pathogenically related to SARS-CoV-2 receptors expressed in the tongue and salivary glands and to SARS-CoV-2 infection-induced zinc deficiency.
Efficacy and Safety of Actinium-225 Prostate-Specific Membrane Antigen Radioligand Therapy in Metastatic Prostate Cancer: A Systematic Review and Metanalysis
This meta-analysis focuses on therapeutic responses, survival effects, and toxicity of Actinium-225 prostate-specific membrane antigen (Ac-225 PSMA) radioligand therapy in metastatic castration-resistant prostate cancer patients.
Patients enrolled in the studies underwent various local and systemic therapies before receiving 225Ac-PSMA.
Evaluation of the CLL-IPI and IPS-E Prognostic Indices in a Young Middle Eastern Population with Chronic Lymphocytic Leukemia: A Retrospective Analysis at the Kuwait Cancer Control Center
The variable clinical course of chronic lymphocytic leukemia and the lack of consensus on follow-up and treatment strategies have necessitated a prognostic model for identifying high-risk patients at the time of diagnosis.
We evaluated the applicability of these for Chronic Lymphocytic Leukemia International Prognostic Index in our young, Middle Eastern cohort (median age 59 years at diagnosis).
Chronic Lymphocytic Leukemia International Prognostic Index discriminates over time to the first treatment.
Sex-Related Bleeding Risk in Acute Coronary Syndrome Patients Receiving Dual Antiplatelet Therapy with Aspirin and a P2Y12 Inhibitor
This study found a two-fold higher risk of major bleeding in women, as compared to men, in subjects with acute coronary syndrome undergoing percutaneous coronary intervention and treated with dual antiplatelet therapy.
This sex difference was caused mainly by an excess femoral access site bleeds in women.
No differences in the incidence of ischemic events between women and men were found.
Dimple of Venus Is Associated with the Increased Pelvic Incidence Angle and More Sagittally Oriented Facet Joint
The presence of the dimple of Venus on physical examination is associated with increased pelvic incidence angle and more sagittally oriented facet joint angle.
These radiological anatomical findings may be a compensation for muscle deficiency in the nature of the dimples.
These findings may help physicians to reduce the need for serial radiological examinations in the evaluation of spinopelvic anatomy.