Objectives: The aim of this study was to present the clinical and histopathological evaluation of reactive gingival lesions, such as peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF), as exemplified in two cases. Clinical Presentation and Intervention: A 12- and a 13-year-old girl were referred to the Department of Pedodontics, both complaining of a painless swelling mass. After histopathological evaluation, the lesions were diagnosed as PGCG and POF. These gingival enlargements were totally resected after adequate clinical and radiological examinations. No recurrence has occurred in the 1-year follow-up period. Conclusion: These cases show that without histopathological evaluation, these two lesions could have been misdiagnosed due to their similarity in appearance. Early detection and treatment of these lesions are important to reduce bone loss or displacement of dental germs or teeth.