More than 80% of children with a life-limiting condition such as cancer or a neurodegenerative disease suffer from pain during their last week of life. This article reviews the principles of pediatric pain management and addresses characteristics and pitfalls of integrative and pharmacological therapies during the end-of-life period of a child.Providing a good pain management for a dying child is one of the many domains of pediatric palliative care and usually requires a holistic, multidisciplinary approach and the knowledge to apply appropriate analgesic drugs in combination with integrative nondrug therapies.

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