Objective: The purpose of this study was to investigate the association between an Alu I RFLP of the calcitonin receptor (CTR) gene and quantitative ultrasound (QUS) parameters in Korean men, and the interaction with nutrition as a lifestyle factor. Materials and Methods: Broadband ultrasound attenuation, speed of sound and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 201 Korean men (mean age ± SD: 51.6 ± 11.7 years). The PCR-RFLP method was used to analyze an Alu I polymorphism in the CTR gene. Results: In all subjects, the distribution of CC, CT and TT genotypes occurred with frequencies of 87.1, 12.4 and 0.5%, respectively. When stratified by omnivore and vegetarian groups, there was a significant association between an Alu I polymorphism in the CTR gene and QUS parameters such as speed of sound and stiffness index in only vegetarian subjects. Conclusion: Our data suggest that the Alu I polymorphism of the CTR gene can be useful as a genetic marker in the interindividual susceptibility of QUS parameters by the interaction with nutritional status as a lifestyle factor.

Keywords:
Bone mineral density, Calcaneus, Calcitonin receptor gene, Vegetarian diet
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© 2007 S. Karger AG, Basel
2007
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