... that could benefit from CYP2C19 and CYP2D6 testing, we simulated the STAR*D algorithm using ethnicity-specific phenotype (e.g., metabolizer status) frequencies published by the Clinical Pharmacogenetics Implementation Consortium and census data from the Canada and the US. We found that up to one-third...

..., instructions or products referred to in the content or advertisements. Antipsychotic agents Weight gain Child Adolescent Leptin Genetics Leptin receptor Biomarker Pharmacogenetics Polymorphism Antipsychotics are now relatively commonly used in children and adolescents for a variety...

... publications and recommendations related to the genetics of antipsychotic treatment and shed light on the clinical utility of pharmacogenetics/pharmacogenomics (PGx). We reviewed the literature on PGx studies with antipsychotic drugs (i.e., antipsychotic response and adverse effects) and commonly used...

...Danielle L. Taylor; Arun K. Tiwari; Jeffrey A. Lieberman; Steven G. Potkin; Herbert Y. Meltzer; Joanne Knight; Gary Remington; Daniel J. Müller; James L. Kennedy Altered glutamate neurotransmission is implicated in the etiology of schizophrenia (SCZ) and the pharmacogenetics of response...

...Raymond R. MacNeil; Daniel J. Müller The effectiveness of antipsychotic drugs is limited due to accompanying adverse effects which can pose considerable health risks and lead to patient noncompliance. Pharmacogenetics (PGx) offers a means to identify genetic biomarkers that can predict individual...