...Caren J. Blacker; Vincent Millischer; Lauren M. Webb; Ada M.C. Ho; Martin Schalling; Mark A. Frye; Marin Veldic Glutamate is implicated in the neuropathology of both major depressive disorder and bipolar disorder. Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter...

... anxiety-/depressive-like state and “four core genotypes” (FCG) mice to probe for sex-specific mechanisms. As predicted, based on previous implications in mood, stress impacted the expression of several dopamine-, GABA-, and glutamate-related genes. Some of these effects, specifically in the prefrontal...

.... We found altered GABA, glutamate and glutamine metabolite levels and ratios as well as increased levels of putrescine and serine – 2 positive modulators of the NMDAR. In addition, GABA receptor (GABAR) protein levels were reduced, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid...

...Danielle L. Taylor; Arun K. Tiwari; Jeffrey A. Lieberman; Steven G. Potkin; Herbert Y. Meltzer; Joanne Knight; Gary Remington; Daniel J. Müller; James L. Kennedy Altered glutamate neurotransmission is implicated in the etiology of schizophrenia (SCZ) and the pharmacogenetics of response...

... to correlate with the differences in plasma amino acid levels within MZ pairs, while no significant correlation was observed after the Bonferroni correction. We observed a familial trait in MMNm strength. The differences in MMN latency in MZ twins might be influenced by changes in glutamate levels...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Common variant Copy number variation Dopamine Genetics Genome-wide association study Glutamate Histamine Linkage analysis Neurotransmitters...

... drive expression of a 5′-truncated SLC1A1 using sequence upstream of exon 2 as a surrogate promoter. However, confocal microscopy and electrophysiological recordings demonstrate that the 5′-truncated SLC1A1 lacks normal membrane localization and glutamate transport ability. To identify downstream...

...-related genes and the parvalbumin gene, peaking at postnatal day (P)21 and P35, respectively. The timing of the peaks is different from that observed in the striatum. Furthermore, the evaluation of the circuitry maturation by measuring extracellular glutamate in the PFC revealed that sensitivity...