... anxiety-/depressive-like state and “four core genotypes” (FCG) mice to probe for sex-specific mechanisms. As predicted, based on previous implications in mood, stress impacted the expression of several dopamine-, GABA-, and glutamate-related genes. Some of these effects, specifically in the prefrontal...

... Sibille Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms. Benzodiazepines (BZ) have broad anxiolytic, but also...

...) 10.13039/100000002 A widely held hypothesis of schizophrenia pathophysiology posits that cortical circuits are in a state of altered excitation-inhibition balance characterized by loss of GABA interneuron function [ 1-4 ]. This hypothesis has been driven by postmortem studies revealing altered...