...Lindsay M. Melhuish Beaupre; Vanessa F. Gonçalves; Clement C. Zai; Arun K. Tiwari; Ricardo S. Harripaul; Deanna Herbert; Natalie Freeman; Daniel J. Müller; James L. Kennedy Sleep disturbance affects about 75% of depressed individuals and is associated with poorer patient outcomes. The genetics...

...Caren J. Blacker; Vincent Millischer; Lauren M. Webb; Ada M.C. Ho; Martin Schalling; Mark A. Frye; Marin Veldic Glutamate is implicated in the neuropathology of both major depressive disorder and bipolar disorder. Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter...

.... In contrast, DZP displayed anxiolytic but no antidepressant effects or effects on working memory. We demonstrate distinct profiles of anxiolytic, antidepressant, and/or pro-cognitive activities of newly designed IBZD amide ligands, suggesting novel therapeutic potential for IBZD derivatives in depression...

... hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human...

... with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to selective serotonin reuptake...

...C. Anthony Altar; Joseph Carhart; Josiah D. Allen; Daniel Hall-Flavin; Joel Winner; Bryan Dechairo DNA of 258 patients with treatment-resistant depression was collected in three 8-10 week, two-arm, prospective clinical trials. Forty-four allelic variations were measured in genes for the cytochrome...

..., despite its heavy burden and high prevalence, the molecular characterization of major depressive disorder (MDD) has lagged behind. Transcriptome studies report multiple brain disturbances but are limited by small sample sizes. Genome-wide association studies (GWAS) report weak results but suggest...