... + antiporter 2 (DHA2) family export systems encoded by A. baumannii were investigated for their roles in promoting the success ofthis organism as a human pathogen. Methods: Bioinformatic tools were used to identify the DHA2 family transporters encoded by Acinetobacter spp. and establish their phylogenetic...

... exporter (AI-2E) superfamily, of putative transporters with no other functionally characterized members. These proteins derive exclusively from bacteria. Many different bacterial kingdoms contain them, although several kingdoms do not. These proteins exhibit a uniform topology with 8 putative transmembrane...

... of the Phosphotransferase System in Clostridium botulinum Wilfrid J. Mitchell Parul Tewatia Philip G. Meaden School of Life Sciences, Heriot-Watt University, Edinburgh, UK Key Words Sugar uptake Transport Phosphotransferase system Abstract Clostridium botulinum is capable of fermenting carbohy- drates, but there have...

...Quentin C. Dumay; Aurore J. Debut; Nahla M. Mansour; Milton H. Saier Jr. Copper (Cu + ) transporters of the Ctr family are sequence diverse eukaryotic proteins that function by an unknown mechanism of action. We have conducted bioinformatic analyses of sequenced Ctr proteins. Multiple paralogues...

... kingdoms. YedZ homologues exhibit conserved histidyl residues in their transmembrane domains that may function in heme binding. Some of the homologues encoded in the genomes of magnetotactic bacteria and cyanobacteria have YedZ domains fused to transport and electron transfer proteins, respectively. One...

...Jeremy Felce; Milton H. Saier Jr. The sulfate permease (SulP) family of secondary carriers (TC #2.A.53) includes functionally characterized members that are inorganic anion:H + symporters and anion:anion antiporters. We here describe members of this family that are fused to non-transporter domains...

...Torsten von Rozycki; Mark A. Schultzel; Milton H. Saier Jr. The primary HCO 3 – uptake system in the cyanobacterium Synecocystis is the Na + -dependent transporter SbtA. SbtA and its homologues were identified and shown to display a common topology of ten transmembrane segments (TMSs). These proved...

... other PTS proteins, suggesting a transport mechanism not coupled to substrate phosphorylation. Topological analyses suggest that in contrast to all other PTS permeases, IIC proteins of the Sga and Gat families exhibit 12 transmembrane α-helical segments and are distantly related to secondary carriers...