... that was collected by nephron micropuncture indicates ultrafiltration of IGF-I, TGF-β and HGF. Respective receptors are also expressed in apical membranes in some parts of the nephron as examined by immunohistochemistry. In vitro cell culture experiments using proximal tubular fluid obtained from rats...

...Erwin P. Böttinger; Jeffrey B. Kopp Aberrant expression of TGF-β and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-β isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased...

... with purified growth factors and analyses of gene expression. Important correlative work using clinical specimens has established the presence of augmented TGF-β expression in renal diseases characterized by excessive sclerosis or fibrosis. While in the aggregate this information supports a compelling argument...

...John J. Letterio; Erwin P. Böttinger Use of homologous recombination and transgenic technologies have provided mouse models to study the physiological roles of the three mammalian TGF-β isoforms, and their regulation in the context of the intact animal. Mice harboring null mutations for TGF-β...

...Anita B. Roberts The TGF-βs are a remarkable set of peptides consisting of three highly homologous isoforms, TGF-β 1, 2, and 3. Distinguished initially for their ability to inhibit the growth of most epithelial and hematopoietic cells and to regulate the production of extracellular matrix...

...Arthur H. Cohen; Cynthia C. Nast The role of TGF-β in pathological processes in the transplanted kidney is beginning to be investigated both in animal models and in humans. In both settings in acute cell-mediated rejection, TGF-β, receptor, and message have all been documented to be elevated...

... from any ideas, methods, instructions or products referred to in the content or advertisements. TGF-β Kidney Renal disease TGF-β receptor Miner Electrolyte Metab 1998;24:107 110 Raimund Hirschberg Division of Nephrology and Hypertension, Harbor-UCLA Medical Center and UCLA, Torrance, Calif...

...Stuart J. Shankland; Richard J. Johnson Transforming growth factor-β (TGF-β) is an important cytokine in glomerular disease. Its major role may be to mediate extracellular matrix deposition, by both increasing the synthesis of matrix components and by reducing their degradation. Strong evidence...

...Jeffrey L. Wrana Transforming growth factor-β (TGF-β) is the founding member of a large superfamily of related growth and differentiation factors that include bone morphogenetic proteins and activins. TGF-β signals through two related transmembrane ser/thr kinase receptors, the type I and type II...

...Mark A. Perrella; Mukesh K. Jain; Mu-En Lee Transforming growth factor-β (TGF-β) is the prototypic member of a large family of structurally related proteins. Three vertebrate TGF-β isoforms have been identified and termed TGF-β1, TGF-β2, and TGF-β3, respectively. In addition, two receptors...

...David P. Basile; Marc R. Hammerman Organogenesis of the metanephric kidney is regulated by a number of polypeptide growth factors. Members of the TGF-β family of growth factors have been shown to be produced in kidney during its development. Available evidence suggests that some of these members...

...Takashi Ando; Seiya Okuda; Taihei Yanagida; Masatoshi Fujishima This paper reviews the expression and localization of proteins of the TGF-β system in the kidney, i.e. TGF-β isoforms, latent TGF-β binding protein, and receptors. There is heterogeneity of TGF-β isoforms, binding proteins...

...Barbara A. Hocevar; Philip H. Howe Mitogenic growth factors stimulate cell growth by initiating a signaling cascade leading to the activation of the cyclin-dependent kinases (cdks), phosphorylation of pRb, and subsequent entry of the cell into the S phase. Transforming growth factor-β (TGF-β...