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Journal Articles

Consensus Guideline of Ablation for Metastatic Liver Tumors by Taiwan Academy of Tumor Ablation

Open Access
Subject Area:
Gastroenterology , Oncology
Ming Shun Wu, Wei-Yu Kao, Ming-Feng Chiang, Po-Heng Chuang, Shih-Jer Hsu, Shen-Yung Wang, Ching-Wei Chang, Chen-Chun Lin, Chao-Hung Hung, Chih-Horng Wu, San-Chi Chen, Hsin-Lun Lee, Jen-I Hwang, Po-Chin Liang, Shi-Ming Lin, Chia-Chi Wang
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546765
Published Online: 19 June 2025
View articletitled, Consensus Guideline of Ablation for Metastatic Liver Tumors by Taiwan Academy of Tumor Ablation
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Journal Articles

Primary analysis of a phase II study of atezolizumab plus bevacizumab for TACE-unsuitable patients with tumor burden beyond up-to-seven criteria in intermediate-stage hepatocellular carcinoma: REPLACEMENT study

Open Access
Subject Area:
Gastroenterology , Oncology
Masatoshi Kudo, Kazuomi Ueshima, Kaoru Tsuchiya, Tatsuya Yamashita, Shigeo Shimose, Kazushi Numata, Yuzo Kodama, Shinji Itoh, Yasuhito Tanaka, Hidekatsu Kuroda, Hiroshi Aikata, Atsushi Hiraoka, Michihisa Moriguchi, Ryosuke Tateishi, Sadahisa Ogasawara, Kouji Yamamoto, Masafumi Ikeda
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546899
Published Online: 19 June 2025
View articletitled, Primary analysis of a phase II study of atezolizumab plus bevacizumab for TACE-unsuitable patients with tumor burden beyond up-to-seven criteria in intermediate-stage hepatocellular carcinoma: REPLACEMENT study
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Journal Articles

Fever Following Treatment with Atezolizumab Plus Bevacizumab Predicts Liver Injury in Patients with Unresectable Hepatocellular Carcinoma: A Prospective Observational Analysis

Open Access
Subject Area:
Gastroenterology , Oncology
Takanori Ito, Takafumi Yamamoto, Kazuki Nishida, Yumiko Kobayashi, Kazuyuki Mizuno, Takaya Suzuki, Shinya Yokoyama, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Toshinari Koya, Sayori Nakashima, Takehito Naito, Satoshi Yasuda, Teiji Kuzuya, Hidenori Toyoda, Yuichi Ando, Sachiyo Yoshio, Hiroki Kawashima
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546967
Published Online: 14 June 2025
View articletitled, Fever Following Treatment with Atezolizumab Plus Bevacizumab Predicts Liver Injury in Patients with Unresectable Hepatocellular Carcinoma: A Prospective Observational Analysis
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Journal Articles

Patient and Physician Preferences for Add-on Systemic Therapy to Transarterial Chemoembolization for Hepatocellular Carcinoma in Japan: A Discrete Choice Experiment

Open Access
Subject Area:
Gastroenterology , Oncology
Junji Furuse, Sachiyo Shirakawa, Ayako Fukui, Takehiro Hirai, Yoko Hamada, Hiroshi Kitagawa
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546693
Published Online: 12 June 2025
View articletitled, Patient and Physician Preferences for Add-on Systemic Therapy to Transarterial Chemoembolization for Hepatocellular Carcinoma in Japan: A Discrete Choice Experiment
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Journal Articles

Updated Network Meta-Analysis of First-Line Systemic Treatments for Advanced HCC: Consistent Role of TACE

Open Access
Subject Area:
Gastroenterology , Oncology
Ye Rim Kim, Euichang Kim, Ha Il Kim, Seungbong Han, Jihyun An, Ju Hyun Shim
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546697
Published Online: 12 June 2025
View articletitled, Updated Network Meta-Analysis of First-Line Systemic Treatments for Advanced HCC: Consistent Role of TACE
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Journal Articles

The evolving role of imaging in hepatocellular carcinoma: from pathomolecular profiling to prognostic decision-making

Open Access
Subject Area:
Gastroenterology , Oncology
Hanyu Jiang, Hong Wei, Lingling Liang, Yanshu Wang, Ming Kuang, Maxime Ronot, Bin Song, Jeong Min Lee
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546966
Published Online: 12 June 2025
View articletitled, The evolving role of imaging in hepatocellular carcinoma: from pathomolecular profiling to prognostic decision-making
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Journal Articles

Prognosis of hepatectomy versus systemic chemotherapy based on oncological resectability criteria for borderline resectable hepatocellular carcinoma

Open Access
Subject Area:
Gastroenterology , Oncology
Shohei Komatsu, Toshifumi Tada, Takashi Nishimura, Motofumi Tanaka, Atsushi Takebe, Saeko Kushida, Yoshimi Fujishima, Nobuaki Ishihara, Takanori Matsuura, Ikuo Nakamura, Taro Okazaki, Masahiro Tsuda, Jun Ishida, Ippei Matsumoto, Seiko Hirono, Hirayuki Enomoto, Yuzo Kodama, Takumi Fukumoto
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546830
Published Online: 10 June 2025
View articletitled, Prognosis of hepatectomy versus systemic chemotherapy based on oncological resectability criteria for borderline resectable hepatocellular carcinoma
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Journal Articles

Society News

Open Access
Subject Area:
Gastroenterology , Oncology
Journal: Liver Cancer
Liver Cancer (2025) 14 (3): 355–356.
https://doi.org/10.1159/000546742
Published Online: 04 June 2025
View articletitled, Society News
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Journal Articles

Reply to the Letter Regarding “Combination Assay of Methylated HOXA1 with Tumor Markers for Detection of Early-Stage Hepatocellular Carcinoma”

Open Access
Subject Area:
Gastroenterology , Oncology
Yuki Kunimune, Yutaka Suehiro, Issei Saeki, Kiyoshi Ichihara, Teppei Yamashita, Taro Takami, Takahiro Yamasaki
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546560
Published Online: 31 May 2025
View articletitled, Reply to the Letter Regarding “Combination Assay of Methylated HOXA1 with Tumor Markers for Detection of Early-Stage Hepatocellular Carcinoma”
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Journal Articles

Depth of Response Predicts Survival in Unresectable HCC Treated with Immunotherapy: Not All Stable Disease Is Equal

Open Access
Subject Area:
Gastroenterology , Oncology
Masatoshi Kudo
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546698
Published Online: 29 May 2025
View articletitled, Depth of Response Predicts Survival in Unresectable HCC Treated with Immunotherapy: Not All Stable Disease Is Equal
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Journal Articles

Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial

Open Access
Subject Area:
Gastroenterology , Oncology
Mengya Zang, Qi Li, Xiaoyun Hu, Huajin Pang, Rong Li, Wenli Li, Yongru Chen, Peilin Zhu, Kaiyan Su, Guosheng Yuan, Yuan Li, Yuanfeng Li, Jinzhang Chen
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546575
Published Online: 26 May 2025
View articletitled, Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial
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Journal Articles

Etiology of hepatocellular carcinoma may influence the pattern of progression under atezolizumab-bevacizumab.

Open Access
Subject Area:
Gastroenterology , Oncology
Bernardo Stefanini, Fabio Piscaglia, Fabio Marra, Massimo Iavarone, Caterina Vivaldi, Giuseppe Cabibbo, Andrea Palloni, Tiziana Pressiani, Andrea Dalbeni, Benedetta Stefanini, Leonardo Stella, Piera Federico, Gianluca Svegliati-Baroni, Sara Lonardi, Caterina Soldà, Luca Ielasi, Stefania De Lorenzo, Ingrid Garajova, Claudia Campani, Mariangela Bruccoleri, Gianluca Masi, Ciro Celsa, Giovanni Brandi, Alessandra Auriemma, Bruno Daniele, Francesca Romana Ponziani, Lorenzo Lani, Rusi Chen, Maria Boe, Alessandro Granito, Lorenza Rimassa, Francesco Tovoli, on behalf of the ARTE study group
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000545494
Published Online: 26 May 2025
View articletitled, Etiology of hepatocellular carcinoma may influence the pattern of progression under atezolizumab-bevacizumab.
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Journal Articles

Transarterial Chemoembolization plus Sorafenib versus Sorafenib Alone in Advanced Hepatocellular Carcinoma (SELECT): a Multicenter, Phase 3, Randomized, Controlled Trial

Open Access
Subject Area:
Gastroenterology , Oncology
Yan Zhao, Wei Bai, Rong Ding, Nan You, Lin Zheng, Lei Li, Jianbing Wu, Peng Zhang, Wukui Huang, Hui Zhang, Yongjin Zhang, Diwen Zhu, Haiping Li, Dongdong Xia, Jie Yuan, Xiaomei Li, Zhengyu Wang, Bohan Luo, Wengang Guo, Zhanxin Yin, Wei Mu, Ming Huang, Jing Li, Weixin Ren, Daiming Fan, Yong Lv, Guohong Han
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546530
Published Online: 22 May 2025
View articletitled, Transarterial Chemoembolization plus Sorafenib versus Sorafenib Alone in Advanced Hepatocellular Carcinoma (SELECT): a Multicenter, Phase 3, Randomized, Controlled Trial
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Journal Articles

The Risk of Decompensation in Steatotic Liver Disease Related Hepatocellular Carcinoma: A Comparison with Viral-controlled Cases

Open Access
Subject Area:
Gastroenterology , Oncology
Yuki Matsushita, Tatsuya Minami, Yoshikuni Kawaguchi, Akihiko Ichida, Ryo Oikawa, Keisuke Mabuchi, Makoto Moriyama, Tomoharu Yamada, Kazuya Okushin, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Mitsuhiro Fujishiro, Kiyoshi Hasegawa, Ryosuke Tateishi
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546492
Published Online: 19 May 2025
View articletitled, The Risk of Decompensation in Steatotic Liver Disease Related Hepatocellular Carcinoma: A Comparison with Viral-controlled Cases
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Journal Articles

Society News

Open Access
Subject Area:
Gastroenterology , Oncology
Journal: Liver Cancer
Liver Cancer (2025) 14 (3): 354.
https://doi.org/10.1159/000546282
Published Online: 12 May 2025
View articletitled, Society News
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Journal Articles

The Concept of “Converse Therapeutic Hierarchy” for Patients with Hepatocellular Carcinoma

Open Access
Subject Area:
Gastroenterology , Oncology
Alessandro Vitale, Giuseppe Cabibbo, Lorenza Rimassa, Massimo Iavarone, Agostino Colli, Laura Crocetti, Timothy M. Pawlik, Andrea Casadei-Gardini, Francesca Romana Ponziani, Irene Bargellini, Francesco Tovoli, Umberto Cillo, Edoardo G. Giannini
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546360
Published Online: 10 May 2025
View articletitled, The Concept of “Converse Therapeutic Hierarchy” for Patients with Hepatocellular Carcinoma
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Journal Articles

Predicting Survival Outcomes in Patients with Hepatocellular Carcinoma Receiving Lenvatinib by Using the Up7-ALBI Score

Open Access
Subject Area:
Gastroenterology , Oncology
Chien-Hung Lu, Wei-Yu Kao, Chih-Horng Wu, Wei-Yi Ting, Chia-Hsun Lu, Kai-I Chuang, Cheng-Fu Ni, Yao-Yu Hsieh, Ming-Shun Wu, Chien-Wei Su, San‑Chi Chen
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546185
Published Online: 29 April 2025
View articletitled, Predicting Survival Outcomes in Patients with Hepatocellular Carcinoma Receiving Lenvatinib by Using the Up7-ALBI Score
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Journal Articles

Current Perspectives on Perioperative Combination Therapy for Hepatocellular Carcinoma

Open Access
Subject Area:
Gastroenterology , Oncology
Takahiro Nishio, Tomoaki Yoh, Hiroto Nishino, Satoshi Ogiso, Yoichiro Uchida, Takamichi Ishii, Etsuro Hatano
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546138
Published Online: 29 April 2025
View articletitled, Current Perspectives on Perioperative Combination Therapy for Hepatocellular Carcinoma
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Journal Articles

Survival Benefit of Hepatectomy after Complete or Partial Response to Conversion Therapy in Unresectable Hepatocellular Carcinoma (GUIDANCE003): A Multicenter Study

Open Access
Subject Area:
Gastroenterology , Oncology
Da-Long Yang, Ning Peng, Jun-Liang Nong, Kang Chen, Ze Su, Ya-Qun Yu, Lin Ye, Fan-Jian Zeng, Shao-Ping Liu, Yi-He Yan, Xue-Yao Wang, Hong-Bing Yao, Fu-Quan Yang, Wen-Feng Li, Chuang Qin, Ming-Song Wu, Yong-Yu Yang, Xiao-Feng Dong, Mian-Jing Li, Jie Liu, Yong-Rong Liang, Pei-Sheng Wu, Teng-Meng Zhong, Yong-Cheng Lai, Yao-Zhi Chen, Qing-Qing Pang, Guo-Dong Wang, Fu-Xin Li, Xian-Shuang Mao, Shu-Chang Chen, Jun-Jie Ou, Rong-Rui Huo, Xiu-Mei Liang, Bang-De Xiang, Liang Ma, Jian-Hong Zhong, on behalf of the GUIDANCE Investigators
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000546052
Published Online: 23 April 2025
View articletitled, Survival Benefit of Hepatectomy after Complete or Partial Response to Conversion Therapy in Unresectable Hepatocellular Carcinoma (GUIDANCE003): A Multicenter Study
Open the PDF for Survival Benefit of Hepatectomy after Complete or Partial Response to Conversion Therapy in Unresectable Hepatocellular Carcinoma (GUIDANCE003): A Multicenter Study in another window
Journal Articles

Matching-Adjusted Indirect Comparison of Arterial FOLFOX and Atezolizumab-Bevacizumab in Unresectable Hepatocellular Carcinoma

Open Access
Subject Area:
Gastroenterology , Oncology
Yi-Min Zhang, Xin-Tong Wu, Jun-Zhe Yi, Jie Xu, Yu-Nan Zhang, Ning Lyu, Ming Zhao
Journal: Liver Cancer
Liver Cancer (2025)
https://doi.org/10.1159/000545891
Published Online: 22 April 2025
View articletitled, Matching-Adjusted Indirect Comparison of Arterial FOLFOX and Atezolizumab-Bevacizumab in Unresectable Hepatocellular Carcinoma
Open the PDF for Matching-Adjusted Indirect Comparison of Arterial FOLFOX and Atezolizumab-Bevacizumab in Unresectable Hepatocellular Carcinoma in another window