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Online First / Early View
Online first articles are accepted and edited, peer reviewed articles that are not yet assigned to volumes/issues, but are citable using DOI.
Online First
Research Articles October 31 2023
Impact of Liver Fibrosis Severity on Oncological Prognosis in Hepatocellular Carcinoma
Koya Yasukawa; Akira Shimizu; Koji Kubota; Tsuyoshi Notake; Kiyotaka Hosoda; Hikaru Hayashi; Yuji Soejima
Liver Cancer (2023) https://doi.org/10.1159/000533857
Systematic Review October 30 2023
Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection Exhibited Favorable Survival from Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
Liver Cancer (2023) https://doi.org/10.1159/000534446
Meta-Analysis October 14 2023
Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis
Andrea Pasta; Francesco Calabrese; Ariel Jaffe; Sara Labanca; Simona Marenco; Giulia Pieri; Maria Corina Plaz Torres; Mario Strazzabosco; Edoardo G. Giannini
Liver Cancer (2023) https://doi.org/10.1159/000533991
Research Articles October 9 2023
Two Distinct Characteristics of Immune Microenvironment in Human Hepatocellular Carcinoma with Wnt/β-Catenin Mutations
Tomoko Aoki; Naoshi Nishida; Yutaka Kurebayashi; Kazuko Sakai; Masahiro Morita; Hirokazu Chishina; Masahiro Takita; Satoru Hagiwara; Hiroshi Ida; Kazuomi Ueshima; Yasunori Minami; Masakatsu Tsurusaki; Takuya Nakai; Michiie Sakamoto; Kazuto Nishio; Masatoshi Kudo
Liver Cancer (2023) https://doi.org/10.1159/000533818
Research Articles October 9 2023
Real-World Data on the Diagnosis, Treatment, and Management of Hepatocellular Carcinoma in the Asia-Pacific: The INSIGHT Study
Yu Ki Sim; Ming Chuen Chong; Mihir Gandhi; Yogesh Mahadev Pokharkar; Yanan Zhu; Luming Shi; Li Lequn; Chien-Hung Chen; Masatoshi Kudo; Joon Hyeok Lee; Simone I. Strasser; Rawisak Chanwat; Pierce K.H. Chow; on behalf of the Asia-Pacific Hepatocellular Carcinoma Trials Group
Liver Cancer (2023) https://doi.org/10.1159/000534513
Review Articles October 4 2023
Genetic/Epigenetic Alteration and Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Transforming the Immune Microenvironment with Molecular-Targeted Agents
Liver Cancer (2023) https://doi.org/10.1159/000534443
Research Articles October 1 2023
Survival Outcome Analysis of Stereotactic Body Radiotherapy and Immunotherapy (SBRT-IO) versus SBRT-Alone in Unresectable Hepatocellular Carcinoma
Chi Leung Chiang; Francis Ann Shing Lee; Kenneth Sik Kwan Chan; Venus Wan Yan Lee; Keith Wan Hang Chiu; Ryan Lok Man Ho; John Ka Shun Fong; Natalie Sean Man Wong; Winnie Wing Ling Yip; Cynthia Sin Yu Yeung; Vince Wing Hang Lau; Kwan Man; Feng-Ming Spring Kong; Albert Chi Yan Chan
Liver Cancer (2023) https://doi.org/10.1159/000533425
Research Articles September 30 2023
PHOCUS: A Phase 3, Randomized, Open-Label Study of Sequential Treatment with Pexa-Vec (JX-594) and Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Ghassan K. Abou-Alfa; Peter R. Galle; Yee Chao; Joseph Erinjeri; Jeong Heo; Mitesh J. Borad; Angelo Luca; James Burke; Adina Pelusio; Delphine Agathon; Monika Lusky; Caroline Breitbach; Shukui Qin; Edward Gane
Liver Cancer (2023) https://doi.org/10.1159/000533650
Research Articles September 14 2023
Incidence and Predictors of Esophagogastric Varices Bleeding in Patients with Hepatocellular Carcinoma in Lenvatinib
Massimo Iavarone; Eleonora Alimenti; Toshifumi Tada; Shigeo Shimose; Goki Suda; Changhoon Yoo; Caterina Soldà; Fabio Piscaglia; Giulia Tosetti; Fabio Marra; Caterina Vivaldi; Fabio Conti; Marta Schirripa; Hideki Iwamoto; Takuya Sho; So Heun Lee; Mario Domenico Rizzato; Matteo Tonnini; Margherita Rimini; Claudia Campani; Gianluca Masi; Francesco Foschi; Mariangela Bruccoleri; Takumi Kawaguchi; Takashi Kumada; Atsushi Hiraoka; Masanori Atsukawa; Shinya Fukunishi; Toru Ishikawa; Kazuto Tajiri; Hironori Ochi; Satoshi Yasuda; Hidenori Toyoda; Takeshi Hatanaka; Satoru Kakizaki; Kazuhito Kawata; Fujimasa Tada; Hideko Ohama; Norio Itokawa; Tomomi Okubo; Taeang Arai; Michitaka Imai; Atsushi Naganuma; Andrea Casadei-Gardini; Pietro Lampertico
Liver Cancer (2023) https://doi.org/10.1159/000534127
Research Articles August 18 2023
MRI Using Gadoxetic Acid in the Work-Up of Liver Nodules Not Conclusively Benign in Budd-Chiari Syndrome: A Prospective Long-Term Follow-Up
Angeles García-Criado; Jordi Rimola; Susana Seijo; Anna Darnell; Ernest Belmonte; Victor Sapena; Julián Moreno-Rojas; Valeria Pérez; Virginia Hernández-Gea; Carmen Ayuso; Maria Reig; Juan Carlos García-Pagán; Jordi Bruix
Liver Cancer (2023) https://doi.org/10.1159/000533598
Meta-Analysis July 29 2023
Atezolizumab in Combination with Bevacizumab for the Management of Patients with Hepatocellular Carcinoma in the First-Line Setting: Systematic Literature Review and Meta-Analysis
Arndt Vogel; Richard S. Finn; Marie-Hélène Blanchet Zumofen; Carolina Heuser; Javier Sanchez Alvarez; Michael Leibfried; Catherine R. Mitchell; Sarah Batson; Gabrielle Redhead; Vincent E. Gaillard; Masatoshi Kudo
Liver Cancer (2023) https://doi.org/10.1159/000533166
Meta-Analysis July 25 2023
Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis
Ciro Celsa; Giuseppe Cabibbo; David James Pinato; Gabriele Di Maria; Marco Enea; Marco Vaccaro; Salvatore Battaglia; Giacomo Emanuele Maria Rizzo; Paolo Giuffrida; Carmelo Marco Giacchetto; Gabriele Rancatore; Maria Vittoria Grassini; Calogero Cammà
Liver Cancer (2023) https://doi.org/10.1159/000531744
Research Articles July 24 2023
Proton Beam Therapy for Intrahepatic Cholangiocarcinoma: A Multicenter Prospective Registry Study in Japan
Masashi Mizumoto; Kazuki Terashima; Hirokazu Makishima; Motohisa Suzuki; Takashi Ogino; Takahiro Waki; Hiromitsu Iwata; Hiroyasu Tamamura; Yusuke Uchinami; Tetsuo Akimoto; Tomoaki Okimoto; Takashi Iizumi; Masao Murakami; Norio Katoh; Kazushi Maruo; Kei Shibuya; Hideyuki Sakurai
Liver Cancer (2023) https://doi.org/10.1159/000531376
Research Articles July 7 2023
Multicenter Phase II Trial of Lenvatinib plus Hepatic Intra-Arterial Infusion Chemotherapy with Cisplatin for Advanced Hepatocellular Carcinoma: LEOPARD
Masafumi Ikeda; Tatsuya Yamashita; Sadahisa Ogasawara; Masatoshi Kudo; Yoshitaka Inaba; Manabu Morimoto; Kaoru Tsuchiya; Satoshi Shimizu; Yasushi Kojima; Atsushi Hiraoka; Kazuhiro Nouso; Hiroshi Aikata; Kazushi Numata; Tosiya Sato; Takuji Okusaka; Junji Furuse
Liver Cancer (2023) https://doi.org/10.1159/000531820
Research Articles July 7 2023
Preoperative Prediction of Microvascular Invasion with Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients with Single Hepatocellular Carcinoma: The Implication of Surgical Decision on the Extent of Liver Resection
Na Reum Kim; Heejin Bae; Hyeo Seong Hwang; Dai Hoon Han; Kyung Sik Kim; Jin Sub Choi; Mi-Suk Park; Gi Hong Choi
Liver Cancer (2023) https://doi.org/10.1159/000531786
Review Articles June 8 2023
Recent Advances in Systemic Therapy for Advanced Intrahepatic Cholangiocarcinoma
Liver Cancer (2023) https://doi.org/10.1159/000531458
Other Types June 5 2023
A Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L Trial
Masatoshi Kudo; Kazuomi Ueshima; Issei Saeki; Toru Ishikawa; Yoshitaka Inaba; Naoki Morimoto; Hiroshi Aikata; Nobukazu Tanabe; Yoshiyuki Wada; Yasuteru Kondo; Masahiro Tsuda; Kazuhiko Nakao; Takanori Ito; Tetsuya Hosaka; Yusuke Kawamura; Teiji Kuzuya; Shunsuke Nojiri; Chikara Ogawa; Hironori Koga; Keisuke Hino; Masafumi Ikeda; Michihisa Moriguchi; Takashi Hisai; Kenichi Yoshimura; Junji Furuse; Yasuaki Arai
Liver Cancer (2023) https://doi.org/10.1159/000531377
Research Articles May 25 2023
Thyroid Dysfunction after Atezolizumab and Bevacizumab Is Associated with Favorable Outcomes in Hepatocellular Carcinoma
Young Shin Song; Hannah Yang; Beodeul Kang; Jaekyung Cheon; Ilhwan Kim; Hyeyeong Kim; Won Suk Lee; Yun Beom Sang; Sanghoon Jung; Ho Yeong Lim; Vincent E. Gaillard; Chan Kim; Hong Jae Chon
Liver Cancer (2023) https://doi.org/10.1159/000531182
Research Articles May 23 2023
Multimodal Integrative Genomics and Pathology Analyses in Neoadjuvant Nivolumab Treatment for Intermediate and Locally Advanced Hepatocellular Carcinoma
Tan-To Cheung; Daniel Wai-Hung Ho; Shirley Xueying Lyu; Qingyang Zhang; Yu-Man Tsui; Tiffany Ching-Yun Yu; Karen Man-Fong Sze; Joyce Man-Fong Lee; Vince Wing-hang Lau; Edward Yin-Lun Chu; Simon Hing-Yin Tsang; Wong-Hoi She; Roland Ching-Yu Leung; Thomas Chung-Cheung Yau; Irene Oi-Lin Ng
Liver Cancer (2023) https://doi.org/10.1159/000531176
Research Articles May 15 2023
Radiologic Patterns Determine the Outcomes of Initial and Subsequent Transarterial Chemoembolization in Intermediate-Stage Hepatocellular Carcinoma
Ya-Wen Hung; I-Cheng Lee; Chen-Ta Chi; Rheun-Chuan Lee; Chien-An Liu; Nai-Chi Chiu; Hsuen-En Hwang; Yee Chao; Ming-Chih Hou; Yi-Hsiang Huang
Liver Cancer (2023) https://doi.org/10.1159/000530950
Research Articles May 11 2023
Incidence of Hyper Progressive Disease in Combination Immunotherapy and Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Monotherapy for Unresectable Hepatocellular Carcinoma
Tomoko Aoki; Masatoshi Kudo; Kazuomi Ueshima; Masahiro Morita; Hirokazu Chishina; Masahiro Takita; Satoru Hagiwara; Hiroshi Ida; Yasunori Minami; Masakatsu Tsurusaki; Naoshi Nishida
Liver Cancer (2023) https://doi.org/10.1159/000531024
Review Articles April 24 2023
Combined Hepatocellular-Cholangiocarcinoma: Biology, Diagnosis, and Management
Liangtao Ye; Julia S. Schneider; Najib Ben Khaled; Peter Schirmacher; Carolin Seifert; Lea Frey; Yulong He; Andreas Geier; Enrico N. De Toni; Changhua Zhang; Florian P. Reiter
Liver Cancer (2023) https://doi.org/10.1159/000530700
Research Articles April 17 2023
HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-Related HCC with Distinct Features
Chiao-Ling Li; Chia-Lang Hsu; You-Yu Lin; Ming-Chih Ho; Hu; Chi-Ling Chen; Tung-Ching Ho; Yung-Feng Lin; Shih-Feng Tsai; Sheng-Tai Tzeng; Chin-Fang Huang; Ya-Chun Wang; Shiou-Hwei Yeh; Pei-Jer Chen
Liver Cancer (2023) https://doi.org/10.1159/000530699
Research Articles April 14 2023
Real-Time Fluorescence Imaging to Identify Cholangiocarcinoma in the Extrahepatic Biliary Tree Using an Enzyme-Activatable Probe
Ryugen Takahashi; Takeaki Ishizawa; Yoshinori Inagaki; Mariko Tanaka; Akira Ogasawara; Yugo Kuriki; Kyohhei Fujita; Mako Kamiya; Tetsuo Ushiku; Yasuteru Urano; Kiyoshi Hasegawa
Liver Cancer (2023) https://doi.org/10.1159/000530645
Research Articles March 31 2023
Transcatheter Arterial Chemoembolization for Treatment-Naive Hepatocellular Carcinoma Has Different Treatment Effects Depending on Central or Peripheral Tumor Location
Kazuo Asano; Ken Kageyama; Akira Yamamoto; Atsushi Jogo; Sawako Uchida-Kobayashi; Etsuji Sohgawa; Kazuki Murai; Norifumi Kawada; Yukio Miki
Liver Cancer (2023) https://doi.org/10.1159/000530441
Research Articles February 23 2023
Computed Tomography-Defined Sarcopenia in Outcomes of Patients with Unresectable Hepatocellular Carcinoma Undergoing Radioembolization: Assessment with Total Abdominal, Psoas, and Paraspinal Muscles
Chih-Horng Wu; Ming-Chih Ho; Chien-Hung Chen; Ja-Der Liang; Kai-Wen Huang; Mei-Fang Cheng; Chih-Kai Chang; Chia-Hung Chang; Po-Chin Liang
Liver Cancer (2023) https://doi.org/10.1159/000529676
Research Articles January 19 2023
Optimizing Survival Benefit by Surgical Resection by the Seven-Eleven Criteria in Barcelona Clinic Liver Cancer Stage A/B Hepatocellular Carcinoma beyond the Milan Criteria
Chian-Tzu Huang; Yu-Long Chu; Tung-Hung Su; Shang-Chin Huang; Tai-Chung Tseng; Shih-Jer Hsu; Sih-Han Liao; Chun-Ming Hong; Chen-Hua Liu; Hung-Chih Yang; Chun-Jen Liu; Pei-Jer Chen; Jia-Horng Kao
Liver Cancer (2023) https://doi.org/10.1159/000529143
Meta-Analysis December 29 2022
Adverse Events of Immune Checkpoint Inhibitor-Based Therapies for Unresectable Hepatocellular Carcinoma in Prospective Clinical Trials: A Systematic Review and Meta-Analysis
Yizhou Zhang; Minghao Wang; Qichen Chen; Yiqiao Deng; Jinghua Chen; Yimin Dai; Sheng Luo; Jianming Xu; Hong Zhao; Jianqiang Cai
Liver Cancer (2022) https://doi.org/10.1159/000528698
Early View
Editorials November 29 2023
Objective Response to Systemic Therapy is a Strong Predictor of Overall Survival in Patients with Unresectable Hepatocellular Carcinoma
Liver Cancer (2023) https://doi.org/10.1159/000535516
Research Articles November 28 2023
Impact of Bevacizumab Being Skipped due to Adverse Events of Special Interest for Bevacizumab in Patients With Unresectable Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab: An Exploratory Analysis of the Phase III IMbrave150 study
Masatoshi Kudo; Kaoru Tsuchiya; Yu-Yun Shao; Richard S. Finn; Peter R. Galle; Michel Ducreux; Ann-Lii Cheng; Tatsuya Yamashita; Hironori Koga; Ryosuke Take; Kyoko Yamada; Takashi Asakawa; Yuki Nakagawa; Masafumi Ikeda
Liver Cancer (2023) https://doi.org/10.1159/000535501
Research Articles November 28 2023
A Multicenter Phase 2 Trial Evaluating the Efficacy and Safety of Preoperative Lenvatinib Therapy for Patients with Advanced Hepatocellular Carcinoma (LENS-HCC Trial)
Akihiko Ichida; Junichi Arita; Etsuro Hatano; Susumu Eguchi; Akio Saiura; Hiroaki Nagano; Junichi Shindoh; Masaji Hashimoto; Nobuyuki Takemura; Kojiro Taura; Yoshihiro Sakamoto; Yu Takahashi; Yasuji Seyama; Yasuharu Sasaki; Kohei Uemura; Norihiro Kokudo; Kiyoshi Hasegawa
Liver Cancer (2023) https://doi.org/10.1159/000535514
Brief Reports November 13 2023
A Phase 1b Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma: Extended Analysis of Study 116
Masatoshi Kudo; Richard S. Finn; Masafumi Ikeda; Max W. Sung; Ari D. Baron; Takuji Okusaka; Masahiro Kobayashi; Hiromitsu Kumada; Shuichi Kaneko; Marc Pracht; Tim Meyer; Satoshi Nagao; Kenichi Saito; Kalgi Mody; Zahra Ramji; Leonid Dubrovsky; Josep M. Llovet
Liver Cancer (2023) https://doi.org/10.1159/000535154
Review Articles November 13 2023
Second-Line Treatment after Failure of Immune Check Point Inhibitors in Hepatocellular Carcinoma: Tyrosine Kinase Inhibitor, Retrial of Immunotherapy, or Locoregional Therapy?
Liver Cancer (2023) https://doi.org/10.1159/000534303
Research Articles May 25 2023
Attempt to Establish Prognostic Predictive System for Hepatocellular Carcinoma Using Artificial Intelligence for Assistance with Selection of Treatment Modality
Atsushi Hiraoka; Takashi Kumada; Toshifumi Tada; Hidenori Toyoda; Kazuya Kariyama; Takeshi Hatanaka; Satoru Kakizaki; Atsushi Naganuma; Ei Itobayashi; Kunihiko Tsuji; Toru Ishikawa; Hideko Ohama; Fujimasa Tada; Kazuhiro Nouso; On behalf of the Real-life Practice Experts for HCC (RELPEC) Study Group
Liver Cancer (2023) https://doi.org/10.1159/000530078
