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Online First / Early View
Online first articles are accepted and edited, peer reviewed articles that are not yet assigned to volumes/issues, but are citable using DOI.
Online First
Review Articles May 10 2025
The Concept of “Converse Therapeutic Hierarchy” for Patients with Hepatocellular Carcinoma
Alessandro Vitale; Giuseppe Cabibbo; Lorenza Rimassa; Massimo Iavarone; Agostino Colli; Laura Crocetti; Timothy M. Pawlik; Andrea Casadei-Gardini; Francesca Romana Ponziani; Irene Bargellini; Francesco Tovoli; Umberto Cillo; Edoardo G. Giannini
Liver Cancer (2025) https://doi.org/10.1159/000546360
Research Articles April 29 2025
Predicting Survival Outcomes in Patients with Hepatocellular Carcinoma Receiving Lenvatinib by Using the Up7-ALBI Score
Chien-Hung Lu; Wei-Yu Kao; Chih-Horng Wu; Wei-Yi Ting; Chia-Hsun Lu; Kai-I Chuang; Cheng-Fu Ni; Yao-Yu Hsieh; Ming-Shun Wu; Chien-Wei Su; San‑Chi Chen
Liver Cancer (2025) https://doi.org/10.1159/000546185
Review Articles April 29 2025
Current Perspectives on Perioperative Combination Therapy for Hepatocellular Carcinoma
Takahiro Nishio; Tomoaki Yoh; Hiroto Nishino; Satoshi Ogiso; Yoichiro Uchida; Takamichi Ishii; Etsuro Hatano
Liver Cancer (2025) https://doi.org/10.1159/000546138
Research Articles April 23 2025
Survival Benefit of Hepatectomy after Complete or Partial Response to Conversion Therapy in Unresectable Hepatocellular Carcinoma (GUIDANCE003): A Multicenter Study
Da-Long Yang; Ning Peng; Jun-Liang Nong; Kang Chen; Ze Su; Ya-Qun Yu; Lin Ye; Fan-Jian Zeng; Shao-Ping Liu; Yi-He Yan; Xue-Yao Wang; Hong-Bing Yao; Fu-Quan Yang; Wen-Feng Li; Chuang Qin; Ming-Song Wu; Yong-Yu Yang; Xiao-Feng Dong; Mian-Jing Li; Jie Liu; Yong-Rong Liang; Pei-Sheng Wu; Teng-Meng Zhong; Yong-Cheng Lai; Yao-Zhi Chen; Qing-Qing Pang; Guo-Dong Wang; Fu-Xin Li; Xian-Shuang Mao; Shu-Chang Chen; Jun-Jie Ou; Rong-Rui Huo; Xiu-Mei Liang; Bang-De Xiang; Liang Ma; Jian-Hong Zhong; on behalf of the GUIDANCE Investigators
Liver Cancer (2025) https://doi.org/10.1159/000546052
Research Articles April 22 2025
Comparison of Gadoxetic Acid-Enhanced Liver Magnetic Resonance Imaging and Contrast-Enhanced Computed Tomography for the Noninvasive Diagnosis of Hepatocellular Carcinoma
Jeong Hee Yoon; Won Chang; Young Kon Kim; Chang Hee Lee; Jeong Woo Kim; Beom Jin Park; Jin-Young Choi; Seung-seob Kim; Hee Sun Park; Eun Sun Lee; Jeong-Sik Yu; Seong Jin Park; Myung-Won You; Myoung-jin Jang; Joon-Il Choi; Jeong Min Lee
Liver Cancer (2025) https://doi.org/10.1159/000545965
Research Articles April 22 2025
Matching-Adjusted Indirect Comparison of Arterial FOLFOX and Atezolizumab-Bevacizumab in Unresectable Hepatocellular Carcinoma
Liver Cancer (2025) https://doi.org/10.1159/000545891
Research Articles April 4 2025
Detection of Circulating mRNA Variants in Hepatocellular Carcinoma Patients Using Targeted RNAseq
Daniel Zezulinski; Maarouf A. Hoteit; David E. Kaplan; Angela Simeone; Tingting Zhan; Cataldo Doria; Fowsiyo Y. Ahmed; Lewis R. Roberts; Timothy M. Block; Aejaz Sayeed
Liver Cancer (2025) https://doi.org/10.1159/000545366
Research Articles April 3 2025
Comparison of Efficacy between Lenvatinib and Bevacizumab in Combination of Immune Checkpoint Inhibitor and Interventional Triple Therapy in Chinese Advanced Hepatocellular Carcinoma: The CLEAP 2302 Study
Zhaolong Pan; Dongming Liu; Junbo Cao; Linlin Fu; Xihao Zhang; Xiaodong Zhu; Yangxun Pan; Jianwei Liu; Chuangye Han; Renan Jin; Shunli Shen; Xiaoyun Zhang; Hongzhi Liu; Xiaobo Yang; Kuan Hu; Xiaoyi Shi; Dongxu Wang; Yang Zhao; Jianhong Zhong; Bangde Xiang; Shanzhi Gu; Tao Li; Shuijun Zhang; Ledu Zhou; Haitao Zhao; Yongyi Zeng; Tianfu Wen; Ming Kuang; Xiao Liang; Tao Peng; Kui Wang; Li Xu; Huikai Li; Tianqiang Song; Huichuan Sun; Wei Zhang; China Liver Cancer Study Group Young Investigators (CLEAP)
Liver Cancer (2025) https://doi.org/10.1159/000545545
Research Articles March 26 2025
Current Surveillance Strategy Is Less Effective for Detecting Early-Stage Hepatocellular Carcinoma in Patients with Non-Viral and Non-Cirrhotic Liver Disease
Jessica Spiers; Wenhao Li; Aloysious D. Aravinthan; Ayman Bannaga; Katharine Caddick; Emma L. Culver; Rosemary E. Faulkes; Victoria Gordon; Yaqza Hussain; Hamish Miller; Jenny Merry; Muhammad Saad; Abhishek Sheth; Tahir Shah; Shishir Shetty; Ankur Srivastava; Mohsan Subhani; Muhammad Nauman Tahir; Nwe Ni Than; Esther Unitt; William Alazawi
Liver Cancer (2025) https://doi.org/10.1159/000542805
Research Articles March 5 2025
18F-FDG PET/CT Predicts the Prognosis of Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation
Wen-Jing Zheng; Yang Xu; Hui Tan; Shu-Guang Chen; Peng-Xiang Wang; Hai-Xiang Sun; Rui-Zhe Li; Hai-Ying Zeng; Yu-Chen Zhong; Jian-Wen Cheng; Jia Fan; Jian Zhou; Hongcheng Shi; Xin-Rong Yang
Liver Cancer (2025) https://doi.org/10.1159/000544966
Research Articles March 3 2025
Depth and Duration of Response Are Associated with Survival in Patients with Unresectable Hepatocellular Carcinoma: Exploratory Analyses of IMbrave150
Masatoshi Kudo; Tatsuya Yamashita; Richard S. Finn; Peter R. Galle; Michel Ducreux; Ann-Lii Cheng; Kaoru Tsuchiya; Naoya Sakamoto; Shuhei Hige; Ryosuke Take; Kyoko Yamada; Yuki Nakagawa; Hayato Takahashi; Masafumi Ikeda
Liver Cancer (2025) https://doi.org/10.1159/000544981
Guidelines March 3 2025
Asian Conference on Tumor Ablation Guidelines for Hepatocellular Carcinoma
Shuichiro Shiina; Ryosuke Tateishi; Joon Il Choi; So Yeon Kim; Zhiqiang Meng; Lujun Shen; Sheng-Nan Lu; Jen-I. Hwang; Maki Tobari; Hitoshi Maruyama; Terguunbileg Batsaikhan; Qing Deng; Lariza Marie Canseco; Yoshinari Asaoka; Shi-Ming Lin; Kai-Wen Huang; Hyunchul Rhim; Ping Liang; Uei Pua; Masatoshi Tanaka; Peihong Wu
Liver Cancer (2025) https://doi.org/10.1159/000544976
Case Reports February 20 2025
Autologous Tumor-Infiltrating Lymphocyte Infusion plus Anti-Programmed Cell Death Protein 1 Therapy to Cure Advanced Hepatocellular Carcinoma following Palliative Hepatectomy
Tian Xia; Tong Yuan; Li-Jun Chen; Chang-Li Wang; Er-Lei Zhang; Bin-Yong Liang; Zun-Yi Zhang; Ming-Wei Wang; Xiao-Ping Chen; Zhi-Yong Huang
Liver Cancer (2025) https://doi.org/10.1159/000544163
Research Articles February 13 2025
Conversion Surgery after Immune Checkpoint Inhibitor-Based Combination Therapy for Initially Unresectable Hepatocellular Carcinoma: A Retrospective Cohort Study
Mingjian Piao; Chengjie Li; Ziyue Huang; Nan Zhang; Jiongyuan Li; Xu Yang; Shuofeng Li; Shanshan Wang; Ziyu Xun; Longhao Zhang; Boyu Sun; Ting Zhang; Xiaobo Yang; Haitao Zhao
Liver Cancer (2025) https://doi.org/10.1159/000543994
Research Articles January 22 2025
Non-Invasive Kupffer-CEUS Enhances the Accuracy of Focal Liver Lesions Diagnosis in Patients with Liver Cirrhosis or Fibrosis: A Prospective Multicenter Study from China
Yunlin Li; Xiao-Ling Yu; Xiang Jing; Hong Yang; Kaiyan Li; Wei Wu; ShiChun Lu; Hong Ding; Guangjian Liu; Wen Cheng; Guangzhi He; Kai Li; Yan Luo; Liping Liu; Tianan Jiang; Guiming Zhou; Xiaoyan Xie; Zhigang Song; Fang-Yi Liu; Jie Yu; Zhi-Yu Han; Zhi-Gang Cheng; Shuilian Tan; Junqing Xi; Xuejuan Dong; Erpeng Qi; Jundong Yao; Xiaocong Dong; Ping Liang
Liver Cancer (2025) https://doi.org/10.1159/000543501
Research Articles January 21 2025
Prognostic Value of Clinical Complete Response for Patients with Initially Unresectable Hepatocellular Carcinoma after Conversion with Triple Therapy
Jun-Yi Wu; Zhen-Xin Zeng; Yi-Nan Li; Zhi-Bo Zhang; Shao-Wu Zhuang; Bin Li; Jian-Yin Zhou; Shu-Qun Li; De-Yi Liu; Han Li; Xiang-Ye Ou; Jia-Yi Wu; Mao-Lin Yan
Liver Cancer (2025) https://doi.org/10.1159/000543602
Research Articles January 21 2025
Multicenter Phase 2 Trial of Second-Line Regorafenib in Patients with Unresectable Hepatocellular Carcinoma after Progression on Atezolizumab plus Bevacizumab
Jaekyung Cheon; Baek-Yeol Ryoo; Hong Jae Chon; Hyung-Don Kim; Min-Hee Ryu; Kyu-Pyo Kim; Beodeul Kang; Richard S. Finn; Stephen Lam Chan; Changhoon Yoo
Liver Cancer (2025) https://doi.org/10.1159/000543666
Research Articles December 28 2024
High Frequency of CTNNB1 Variants Associated with Benign and Malignant Liver Tumors in Patients with Congenital Porto-Systemic Shunts
Athanasios Tyraskis; Yoh Zen; Sandra Strautnieks; Riley Cook; Pierre Foskett; Claudio De Vito; Maesha Deheragoda; Alberto Quaglia; Nigel Heaton; Mark Davenport; Richard J. Thompson
Liver Cancer (2024) https://doi.org/10.1159/000543217
Research Articles December 18 2024
Regorafenib for Hepatocellular Carcinoma in Real-World Practice (REFINE): A Prospective, Observational Study
Yoon Jun Kim; Philippe Merle; Richard S. Finn; Masatoshi Kudo; Heinz-Josef Klümpen; Ho Yeong Lim; Masafumi Ikeda; Alessandro Granito; Gianluca Masi; René Gerolami; Sung Bum Cho; Chih-Hung Hsu; Yi-Hsiang Huang; Long-Bin Jeng; Do Young Kim; Shi-Ming Lin; Matthias Pinter; Guoliang Shao; Naoya Kato; Masayuki Kurosaki; Kazushi Numata; Kung-Kai Kuo; Yilei Mao; Yih-Jyh Lin; Kangshun Zhu; Philip Twumasi-Ankrah; Javeed Khan; Maria Awan; Kirhan Ozgurdal; Shukui Qin
Liver Cancer (2024) https://doi.org/10.1159/000542285
Letters December 10 2024
Combination Assay of Methylated HOXA1 with Tumor Markers for Detection of Early-Stage Hepatocellular Carcinoma
Liver Cancer (2024) https://doi.org/10.1159/000543002
Research Articles December 4 2024
Treatment Duration of Adjuvant Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Patients at High Risk of Recurrence after Resection: A Prospective, Multicentric Cohort Study
Jia-Yong Su; Shao-Ping Liu; Xiao-Ling Xu; Jun-Jie Ou; Po-Hua Ye; Bin-Tong Zhao; Jia-Song Chen; Qiu-Mei Luo; Jin-Rong Liu; Fei-Min Tang; Jian-Rong Li; Da-Long Yang; Zhu-Jian Deng; Li-Xin Pan; Yao-Jie Li; Le Li; Zhen-Ming Qin; Xiu-Mei Liang; Yi-Li Ma; Liang Ma; Jian-Hong Zhong
Liver Cancer (2024) https://doi.org/10.1159/000542954
Review Articles November 21 2024
Immunometabolic Targets in CD8+ T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma
Yanze Lin; Rexiati Ruze; Ruiqing Zhang; Talaiti Tuergan; Maolin Wang; Alimu Tulahong; Dalong Zhu; Zhongdian Yuan; Tiemin Jiang; Tuerganaili Aji; Yingmei Shao
Liver Cancer (2024) https://doi.org/10.1159/000542578
Research Articles November 14 2024
First-Line Lenvatinib plus Pembrolizumab for Hepatocellular Carcinoma: Post hoc Analysis of Japanese Patients from the Phase 3 LEAP-002 Trial
Masatoshi Kudo; Masafumi Ikeda; Hiroshi Aikata; Kazushi Numata; Hiroyuki Marusawa; Tetsuya Hosaka; Naoya Kato; Masayuki Kurosaki; Manabu Morimoto; Tatsuya Yamashita; Hironori Koga; Tsutomu Masaki; Naoyoshi Yatsuzuka; Masato Suzuki; Satoshi Nagao; Shuichi Kaneko; Hiromitsu Kumada
Liver Cancer (2024) https://doi.org/10.1159/000542572
Early View
Research Articles June 19 2025
Primary analysis of a phase II study of atezolizumab plus bevacizumab for TACE-unsuitable patients with tumor burden beyond up-to-seven criteria in intermediate-stage hepatocellular carcinoma: REPLACEMENT study
Masatoshi Kudo; Kazuomi Ueshima; Kaoru Tsuchiya; Tatsuya Yamashita; Shigeo Shimose; Kazushi Numata; Yuzo Kodama; Shinji Itoh; Yasuhito Tanaka; Hidekatsu Kuroda; Hiroshi Aikata; Atsushi Hiraoka; Michihisa Moriguchi; Ryosuke Tateishi; Sadahisa Ogasawara; Kouji Yamamoto; Masafumi Ikeda
Liver Cancer (2025) https://doi.org/10.1159/000546899
Guidelines June 19 2025
Consensus Guideline of Ablation for Metastatic Liver Tumors by Taiwan Academy of Tumor Ablation
Ming Shun Wu; Wei-Yu Kao; Ming-Feng Chiang; Po-Heng Chuang; Shih-Jer Hsu; Shen-Yung Wang; Ching-Wei Chang; Chen-Chun Lin; Chao-Hung Hung; Chih-Horng Wu; San-Chi Chen; Hsin-Lun Lee; Jen-I Hwang; Po-Chin Liang; Shi-Ming Lin; Chia-Chi Wang
Liver Cancer (2025) https://doi.org/10.1159/000546765
Research Articles June 14 2025
Fever Following Treatment with Atezolizumab Plus Bevacizumab Predicts Liver Injury in Patients with Unresectable Hepatocellular Carcinoma: A Prospective Observational Analysis
Takanori Ito; Takafumi Yamamoto; Kazuki Nishida; Yumiko Kobayashi; Kazuyuki Mizuno; Takaya Suzuki; Shinya Yokoyama; Kenta Yamamoto; Norihiro Imai; Yoji Ishizu; Takashi Honda; Masatoshi Ishigami; Toshinari Koya; Sayori Nakashima; Takehito Naito; Satoshi Yasuda; Teiji Kuzuya; Hidenori Toyoda; Yuichi Ando; Sachiyo Yoshio; Hiroki Kawashima
Liver Cancer (2025) https://doi.org/10.1159/000546967
Review Articles June 12 2025
The evolving role of imaging in hepatocellular carcinoma: from pathomolecular profiling to prognostic decision-making
Hanyu Jiang; Hong Wei; Lingling Liang; Yanshu Wang; Ming Kuang; Maxime Ronot; Bin Song; Jeong Min Lee
Liver Cancer (2025) https://doi.org/10.1159/000546966
Systematic Review June 12 2025
Updated Network Meta-Analysis of First-Line Systemic Treatments for Advanced HCC: Consistent Role of TACE
Liver Cancer (2025) https://doi.org/10.1159/000546697
Research Articles June 12 2025
Patient and Physician Preferences for Add-on Systemic Therapy to Transarterial Chemoembolization for Hepatocellular Carcinoma in Japan: A Discrete Choice Experiment
Liver Cancer (2025) https://doi.org/10.1159/000546693
Research Articles June 10 2025
Prognosis of hepatectomy versus systemic chemotherapy based on oncological resectability criteria for borderline resectable hepatocellular carcinoma
Shohei Komatsu; Toshifumi Tada; Takashi Nishimura; Motofumi Tanaka; Atsushi Takebe; Saeko Kushida; Yoshimi Fujishima; Nobuaki Ishihara; Takanori Matsuura; Ikuo Nakamura; Taro Okazaki; Masahiro Tsuda; Jun Ishida; Ippei Matsumoto; Seiko Hirono; Hirayuki Enomoto; Yuzo Kodama; Takumi Fukumoto
Liver Cancer (2025) https://doi.org/10.1159/000546830
Letters May 31 2025
Reply to the Letter Regarding “Combination Assay of Methylated HOXA1 with Tumor Markers for Detection of Early-Stage Hepatocellular Carcinoma”
Yuki Kunimune; Yutaka Suehiro; Issei Saeki; Kiyoshi Ichihara; Teppei Yamashita; Taro Takami; Takahiro Yamasaki
Liver Cancer (2025) https://doi.org/10.1159/000546560
Editorials May 29 2025
Depth of Response Predicts Survival in Unresectable HCC Treated with Immunotherapy: Not All Stable Disease Is Equal
Liver Cancer (2025) https://doi.org/10.1159/000546698
Research Articles May 26 2025
Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial
Mengya Zang; Qi Li; Xiaoyun Hu; Huajin Pang; Rong Li; Wenli Li; Yongru Chen; Peilin Zhu; Kaiyan Su; Guosheng Yuan; Yuan Li; Yuanfeng Li; Jinzhang Chen
Liver Cancer (2025) https://doi.org/10.1159/000546575
Research Articles May 26 2025
Etiology of hepatocellular carcinoma may influence the pattern of progression under atezolizumab-bevacizumab.
Bernardo Stefanini; Fabio Piscaglia; Fabio Marra; Massimo Iavarone; Caterina Vivaldi; Giuseppe Cabibbo; Andrea Palloni; Tiziana Pressiani; Andrea Dalbeni; Benedetta Stefanini; Leonardo Stella; Piera Federico; Gianluca Svegliati-Baroni; Sara Lonardi; Caterina Soldà; Luca Ielasi; Stefania De Lorenzo; Ingrid Garajova; Claudia Campani; Mariangela Bruccoleri; Gianluca Masi; Ciro Celsa; Giovanni Brandi; Alessandra Auriemma; Bruno Daniele; Francesca Romana Ponziani; Lorenzo Lani; Rusi Chen; Maria Boe; Alessandro Granito; Lorenza Rimassa; Francesco Tovoli; on behalf of the ARTE study group
Liver Cancer (2025) https://doi.org/10.1159/000545494
Research Articles May 22 2025
Transarterial Chemoembolization plus Sorafenib versus Sorafenib Alone in Advanced Hepatocellular Carcinoma (SELECT): a Multicenter, Phase 3, Randomized, Controlled Trial
Yan Zhao; Wei Bai; Rong Ding; Nan You; Lin Zheng; Lei Li; Jianbing Wu; Peng Zhang; Wukui Huang; Hui Zhang; Yongjin Zhang; Diwen Zhu; Haiping Li; Dongdong Xia; Jie Yuan; Xiaomei Li; Zhengyu Wang; Bohan Luo; Wengang Guo; Zhanxin Yin; Wei Mu; Ming Huang; Jing Li; Weixin Ren; Daiming Fan; Yong Lv; Guohong Han
Liver Cancer (2025) https://doi.org/10.1159/000546530
Research Articles May 19 2025
The Risk of Decompensation in Steatotic Liver Disease Related Hepatocellular Carcinoma: A Comparison with Viral-controlled Cases
Yuki Matsushita; Tatsuya Minami; Yoshikuni Kawaguchi; Akihiko Ichida; Ryo Oikawa; Keisuke Mabuchi; Makoto Moriyama; Tomoharu Yamada; Kazuya Okushin; Takuma Nakatsuka; Masaya Sato; Yotaro Kudo; Mitsuhiro Fujishiro; Kiyoshi Hasegawa; Ryosuke Tateishi
Liver Cancer (2025) https://doi.org/10.1159/000546492
