This review summarizes the contents of a workshop on multimodality management for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) held on July 6, 2013, under the auspices of the 4th Asia-Pacific Primary Liver Cancer Expert Meeting Scientific Advisory Committee. BCLC stage C HCC represents a varied disease spectrum and, therefore, further stratification of BCLC stage C should be explored. Although sorafenib is currently the standard treatment for BCLC stage C HCC, the survival benefits are modest and new treatment strategies are still needed. Based on the opinions of Asian experts, there are numerous alternative options aside from sorafenib for the treatment of BCLC stage C HCC, including surgical resection, hepatic arterial infusion chemotherapy, transarterial chemoembolization, and external radiotherapy. Moreover, there are several studies on the multimodality management of BCLC stage C HCC, mainly in the form of retrospective studies and a few phase I and II trials. Multimodality management with combinations of various locoregional therapies or locoregional therapies with systemic targeted therapy using sorafenib needs to be actively investigated. The Asia-Pacific clinical practice guidelines on multimodality management for BCLC stage C HCC need recommendations based on the level of evidence, the strength of the data, and the strength of recommendations of previously reported systems.

A workshop on multimodality management for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) was held on July 6, 2013, under the auspices of the 4th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE) Scientific Advisory Committee. Several experts and observers from different specialties of HCC management, including hepatology, surgical oncology, and radiation oncology, participated in the workshop. The workshop was convened to discuss successful management of BCLC stage C (advanced stage) HCC using a multimodality approach. This communication is based on the observations made during the workshop and on reports from four experts from three Asian countries (Korea, Japan, and China) and contains an in-depth discussion by three experts on the panel.

There are several staging systems aimed at estimating the life expectancy of HCC patients, but only the BCLC staging and treatment strategy links staging with treatment [1,2]. BCLC stage C is defined as cases with an HCC-related Eastern Cooperative Oncology Group performance status of 1 or 2, macrovascular invasion (either segmental or portal invasion), or extrahepatic spread (lymph node involvement or metastases). According to the BCLC guidelines, and based on evidence from randomized clinical trials, only sorafenib is currently recommended for the treatment of BCLC stage C HCC. The Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) []3] and Asia-Pacific trial []4] found that treatment of HCC patients with sorafenib results in improved overall survival. However, most patients treated with sorafenib achieve only stable disease as the best radiologic response, with a median gain in overall survival of less than 3 months []3, 4[]. Therefore, additional management strategies need to be identified and optimized to improve therapeutic benefits.

BCLC stage C represents a varied disease spectrum. A proportion of patients in BCLC stage C do not fulfill all the criteria for sorafenib allocation, and in those cases, the current advice is to offer the second most suitable option within the same stage. Moreover, treatment for locoregional HCC differs from the treatment for systemic HCC with extrahepatic spread and, therefore, BCLC stage C could potentially be subdivided into a locally advanced stage without extrahepatic spread and an extrahepatic advanced stage, based on the opinions of Asian experts []5, 6[]. Further stratification of patients within BCLC stage C according to liver function, prognostic molecular biomarkers, or prognostic variables should also be explored []2, 7[].

According to the treatment algorithm used in Asian countries, various treatment modalities can be tried for BCLC stage C []8-15]. Multimodality management with combinations of various locoregional therapies such as transcatheter arterial chemoembolization (TACE) []16], hepatic arterial infusion chemotherapy (HAIC) []17], and radiotherapy (RT) []18-24], or combinations of locoregional therapies and targeted therapy using sorafenib may also be beneficial for BCLC stage C HCC []25-27].

Systemic therapies such as systemic chemotherapy, hormonal compounds, and immuno-therapy, among others, have demonstrated inconclusive or negative results in previous studies and are generally regarded as inadequate because they are ineffective or result in high rates of toxicity []2]. Intra-arterial chemotherapy is associated with improved therapeutic effects because of the increased local concentration and lower systemic toxicity compared with systemic chemotherapy, and HAIC with anticancer agents such as high-dose 5-fluorouracil (5-FU) or cisplatin has been demonstrated to achieve effective and safe results in patients with HCC with portal vein tumor thrombosis (PVTT) []17, 28-30[].

Localized concurrent HAIC with 5-FU and RT followed by HAIC with 5-FU and cisplatin was tried in a pilot clinical trial for locally advanced HCC with PVTT [21]. All patients had Child Pugh A liver function. The drug was administered continuously for 24h through the hepatic artery using an implanted infusion port concurrently with three-dimensional conformal RT (3D-CRT). The total RT dose was 45 Gy over 5 weeks, and the hepatic arterial infusion (HAI) consisted of 500 mg/day of 5-FU administered during the first and fifth weeks of RT. After RT, HAI with 5-FU and cisplatin was administered every 4 weeks (fig. 1). The overall tumor response rate was 45% (18/40 patients), the 3 year overall survival rate was 24.1%, and the median survival time was 13.1 months from the start of RT. Other studies, mostly retrospective, have established the efficacy of RT in treating HCC with PVTT, with reported median survival times ranging from 4 to 12 months and a generally favorable toxicity profile []31]. Furthermore, a combination of HAI 5-FU and subcutaneous interferon with image-guided RT (IGRT) for locally advanced HCC with PVTT has been compared with a non-IGRT patient group in a retrospective study; improved median survival (12.0 vs. 9.1 months) and time-to-progression (6.9 vs. 4.0 months) were apparent in the IGRT group []32].

Fig. 1

Time course of localized concurrent intra-arterial chemotherapy plus external beam radiotherapy (CCRT) in patients with locally advanced hepatocellular carcinoma with portal vein tumor thrombus. Dx=diagnosis; AG=angiography; R15=indocyanine green R15; AFP=alpha-fetoprotein.

Fig. 1

Time course of localized concurrent intra-arterial chemotherapy plus external beam radiotherapy (CCRT) in patients with locally advanced hepatocellular carcinoma with portal vein tumor thrombus. Dx=diagnosis; AG=angiography; R15=indocyanine green R15; AFP=alpha-fetoprotein.

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HAIC provides moderate therapeutic efficacy and survival benefits with substantially tolerable toxicity profiles in patients with advanced HCC based on the opinions of Asian experts. A combination of HAIC and RT is a promising multimodality approach for the management of patients with locally advanced HCC with PVTT. However, a randomized clinical trial is required to assess the feasibility and efficacy of this approach.

TACE is the recommended treatment for BCLC stage B (intermediate stage) HCC and is considered as primary or palliative treatment for unresectable HCC [1,2,33]. However, its efficacy is unsatisfactory in most patients with PVTT, especially in patients with HCC with main portal vein invasion []33, 34[]. Some studies have shown that single TACE does not induced complete tumor necrosis, that repeated TACE frequently becomes ineffective because of tumor regression, and that TACE is contraindicated for patients with PVTT or inferior vena cava (IVC) invasion because of the potential risks of ischemic liver damage []22, 35[]. Even in encapsulated tumors, which are the favorable tumor type indicated for TACE, the necrosis rate is reported to be only 44% when tumors are larger than 3 cm []36].

RT can effectively ameliorate the limitations of TACE through its antitumor and antivascular effects, and RT may also interact positively with the chemotherapeutic drug if the drug remains in the tumor after TACE []23]. In the first report of combination treatment using TACE and RT by Seong et al. []37], the overall tumor response rate was 63.3%, with a median survival time of 17 months. Salvage RT has also been attempted for unresectable HCC patients when TACE has failed, resulting in a 66.7% response rate and a median survival time of 14 months [38]. In a previous non-randomized study comparing TACE followed by RT vs. TACE followed by no treatment or repeat TACE, a statistically significant improvement in survival was observed in patients treated with TACE plus RT compared to repeated TACE alone (2-year survival rate 37% vs. 14%, respectively, p < 0.01) []39]. A systematic review and meta-analysis involving a total of 1476 patients from 5 randomized controlled trials and 17 nonrandomized trials was performed in Asia []22]. The results of this meta-analysis showed that TACE plus RT, compared with TACE alone for unresectable HCC, significantly improved the survival and the tumor response of patients and was thus more therapeutically beneficial. Three approaches to the combination of TACE and RT have been reported []22, 40[]. The first approach involves using RT to treat PVTT only and using TACE to treat the primary HCC. The second approach involves delivering RT as a “consolidation” planned procedure to target cancer cells at the tumor periphery that may remain viable through blood supplied from collateral circulation or recanalization of the embolized artery after TACE []41]. The third approach involves RT being used as a salvage treatment option for unresponsive HCC despite repeated TACE. However, to select the optimum approach for combining TACE and RT, BCLC staging and identification of the extent of underlying liver functions should be considered, and randomized studies of TACE with or without RT are warranted.

To the best of our knowledge, clear results regarding the significance of the optimal RT dose and appropriate fractionation for HCC patients treated with TACE plus RT have not yet been described. However, some retrospective studies demonstrated that the total RT dose was a significant prognostic factor for overall survival in HCC patients treated with TACE plus RT and should not be less than 45 Gy by conventional fractionation (i.e., 1.8-2 Gy/fraction, and five fractions per week) for targeting the primary tumor and PVTT []42, 43[]. In a recent phase II nonrandomized trial of stereotactic body RT (SBRT) as a local salvage treatment after incomplete TACE in HCC patients, it was observed that an improved local control rate was significantly influenced by a higher RT dose (>54 Gy in three fractions) [44]. Taken together, these results suggest that escalation of the RT dose may improve local control and overall survival.

While TACE combined with RT is a promising treatment for unresectable HCC, further clarification regarding the optimal RT dose, optimal RT fractionation, and optimal interval between TACE and RT is still needed. A randomized study of TACE versus RT for BCLC stage C HCC without extrahepatic spread will help to clarify the role of RT in this setting.

The majority of HCC patients are not diagnosed in the early stages of the disease and are therefore not eligible for potentially curative treatments such as surgical resection, liver transplantation (LT), or local ablation. Ideal candidates for curative treatment make up fewer than 30-40% of all diagnosed HCC cases [1,2]. The major limitation of LT as a curative treatment of HCC is the scarcity of donors. Increases in waiting time have led to approximately 20% of patients on waiting lists dropping out before undergoing LT []45]. Fortunately, downstaging using locoregional therapies, including TACE, radiofrequency ablation (RFA), HAIC, RT, and selective radioembolization with Yttrium-90-labeled microspheres, may offer patients who are not initially candidates for curative treatment a chance to undergo such treatment, e.g., resection or LT []20, 46-49[]. Downstaging for resection or LT should be differentiated from neoadjuvant therapy: in the former, the tumor is unresectable before treatment either because of the local extent of the disease or because of distant metastasis, whereas in the latter, patients are within the Milan criteria, and treatments are given preoperatively to improve the results of surgery or to prevent tumor progression in patients on the waiting list for LT [1,2,20].

In this workshop, institutional experiences of resection and LT after downstaging concurrent chemoradiotherapy (CCRT) were introduced by one Korean expert [unpublished data]. From 2005 to 2011, a total of 267 patients with locally advanced and unresectable HCC received CCRT followed by HAIC at one institution in Korea. CCRT followed by HAIC made it feasible to perform surgical resection in 41 (16.9%) patients after downstaging and/or hypertrophy of the future remnant liver. Surgical resection after downstaging showed good long-term outcomes (49.6% overall 5 year survival rate) and offered the possibility of a cure in a proportion of patients with unresectable HCC. Living donor LT was performed as rescue treatment in nine patients with progressive deteriorating liver function after downstaging CCRT. The expert explained that the early results of LT after downstaging CCRT seem favorable, but that long-term oncologic outcomes must also be demonstrated before any conclusions can be drawn.

An example of a patient who underwent surgical resection after downstaging CCRT is illustrated in fig. 2. In brief, a 41-year-old man was diagnosed with hepatitis B virus (HBV)-related HCC beyond the Milan criteria. A computed tomography (CT) scan demonstrated findings typical of liver cirrhosis and an approximately 11-cm hypervascular mass in the right lobe of the liver with invasion of the middle hepatic vein and IVC. The patient underwent CCRT (45 Gy in 25 fractions over 5 weeks with HAIC using 5-FU at a dose of 500mg/day administered during the first and fifth weeks of RT) as an initial treatment modality. This was followed by the combined use of HAIC using 5-FU (750 mg/m2 for 5h on days 1-3) and cisplatin (60 mg/m2 for 2h on day 2) every 4 weeks (from the third to the eleventh cycle of HAIC) to treat the remaining HCC. Because a clinical complete response (CR) was observed in the follow-up CT scan after these combination treatments, the patient underwent right hepatectomy with curative aim; complete pathologic tumor necrosis was noted. The patient was alive and recurrence-free 7 years post-treatment.

Fig. 2

(a) Initial dynamic CT scan of the liver in a 41year-old patient with inferior vena cava thrombus (IVC, black arrow). (b) Isodose lines encompassing both the primary hepatocellular carcinoma and IVC thrombus, a bold yellow line encompassed normal organ (“Liver”). This line defined the outline of the liver. (c) Follow-up dynamic CT liver scan after concurrent chemoradiotherapy followed by the eleventh cycle of HAIC showing clinical complete response (disappearance of the IVC thrombus and arterial enhancing portion). (d) Surgical specimen from right hepatectomy showing pathologic complete tumor necrosis.

Fig. 2

(a) Initial dynamic CT scan of the liver in a 41year-old patient with inferior vena cava thrombus (IVC, black arrow). (b) Isodose lines encompassing both the primary hepatocellular carcinoma and IVC thrombus, a bold yellow line encompassed normal organ (“Liver”). This line defined the outline of the liver. (c) Follow-up dynamic CT liver scan after concurrent chemoradiotherapy followed by the eleventh cycle of HAIC showing clinical complete response (disappearance of the IVC thrombus and arterial enhancing portion). (d) Surgical specimen from right hepatectomy showing pathologic complete tumor necrosis.

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There are two unresolved issues for surgical resection after downstaging therapy: (1) the definition of unresectability of HCC and (2) the need for resection in tumors with clinical complete response (as determined by radiological findings or tumor markers) after down-staging therapy. The criteria for the unresectability of HCC depends on many factors, including the general condition of the patient, the stage of the disease, the liver function of the patient, and the choice of patient as well as the treatment protocol and availability of expertise in the individual medical center. Thus, the decision on whether HCC is resectable is still subjective. Although patients have reportedly experienced radiological CR after down-staging therapy, there is currently no evidence of a strong correlation between clinical and pathologic CR in the medical literature. Therefore, to induce a CR and to obtain pathological information, surgical resection may be required after tumor downstaging even in cases of radiological CR and tumor makers within the normal range.

Regarding downstaging therapy for resection or LT, to our knowledge, there have been no randomized trials, large case-control studies, or large well-designed cohort studies with patients treated consistently and properly followed-up [1,2,5,6]. Furthermore, because studies on downstaging therapy followed by salvage resection are rare, the evidence in the medical literature regarding this approach is more limited than for downstaging therapy followed by LT []20]. Therefore, the role of surgical resection or LT after tumor downstaging in improving disease-free and overall survival in patients with unresectable HCC should be further investigated in well-designed prospective studies.

Although much progress has been made, many unresolved issues remain with respect to the use of RT as a part of multimodality treatment for BCLC stage C HCC. BCLC stage C HCC is often accompanied by macrovascular invasion, which decreases blood supply to the normal liver parenchyma and causes a deterioration in liver function, consequently limiting the application of TACE for HCC []50]. PVTT occasionally invades the IVC through the hepatic vein. Disseminated tumor thrombi can cause severe and lethal complications, such as pulmonary metastases, pulmonary infarction, or heart failure []51]. RT as a therapeutic option for relieving and/or stabilizing PVTT can delay intravascular tumor growth and the deterioration of liver function by preserving adequate portal flow; RT can also facilitate subsequent treatment of the primary HCC []50-52]. Overall tumor response rates of RT for HCC patients with PVTT have been reported to be 28.1-59.3%, and the response to RT was correlated with better survival in several studies (table 1) []51-57].

Table 1

Selected studies reporting results of radiotherapy or locally advanced hepatocellular carcinoma with portal vein tumor thrombus

Selected studies reporting results of radiotherapy or locally advanced hepatocellular carcinoma with portal vein tumor thrombus
Selected studies reporting results of radiotherapy or locally advanced hepatocellular carcinoma with portal vein tumor thrombus

There is currently no consensus regarding the optimal RT volume useful for HCC patients with PVTT []23]. Some studies included only PVTT in the RT volume, with the primary HCC being treated by local therapies such as TACE, resection, or RFA. However, if the primary tumor in these studies was small and was close to the PVTT in the RT volume, both the primary tumor and PVTT were irradiated []51-53], resulting in an overall tumor response rate of 45.5-50%. Other studies included PVTT as well as primary HCC in the RT volume []54-56] and reported overall tumor response rates of 28.1-59.3%, with CR rates lower than 10% (table 1). Although targeting both the primary tumor and PVTT appears to be associated with better overall outcomes than targeting PVTT alone, targeting PVTT alone may still be useful in some situations []23].

No consensus currently exists regarding the optimum RT dose and fractionation schedule for HCC. Direct comparison between studies is difficult because the survival of HCC patients depends largely on the degree of impairment of hepatic function, coexisting liver cirrhosis, and the extent of the tumor (e.g., number, size, tumor thrombosis extent). In a retrospective cohort study, various dose fractionation schemes such as multiple daily fractionation (hyper-fractionation), conventional fractionation, and hypofractionation using SBRT were analyzed []58]. This study revealed that even with different dose schedules, a higher RT dose was associated with improved prognosis. Schemes of hypofractionation using SBRT and particle beam RT for HCC with PVTT have demonstrated promising outcomes in several studies []23, 31[]; however, there are currently limited data available regarding the efficacy of this treatment for BCLC stage C HCC.

Non-irradiated liver is highly capable of regeneration and functional compensation, and the radiation tolerance dose of the liver depends on the irradiated liver volume []59]. A high RT dose can be delivered to a small volume of liver without significantly impairing its function. In RT planning, the irradiated volume of liver receiving a low RT dose (≤10 Gy) is less of a concern than the irradiated volume of liver receiving a high RT dose. However, especially in HBV endemic areas, low RT doses are capable of inducing HBV reactivation or chronic hepatitis B exacerbation; we should thus minimize the use of low RT doses, monitor HBV DNA levels carefully after RT, and recommend antiretroviral therapy for hepatitis B patients before initiating RT for HCC []60, 61[]. Therefore, while low doses of RT are generally safe, the associated risks are not negligible.

Recent sequential phase I and II trials of SBRT for locally advanced HCC have demonstrated that SBRT can lead to sustained local control with a low risk of serious toxicity and is associated with survival rates higher than those for historical controls []62]. A total of 65.7% of the patients in this study were classified as BCLC stage C; the median overall survival was 17.0 months and the median time to progression was 6.0 months. However, tumor progression outside the SBRT field appeared to be a problem in this study. In another recent study aimed at investigating the effects of two administration schedules of sorafenib and RT in vitro and in vivo []25], it was demonstrated that sorafenib suppressed clonogenic survival after RT in HCC cells and enhanced the antitumor effect of RT in a dose-dependent manner. These results suggest that sorafenib plus RT could represent an effective management strategy for patients with BCLC stage C HCC; this strategy warrants further investigation. Furthermore, tumor progression outside the SBRT field may provide a rationale for combining SBRT with sorafenib []62]. A randomized phase III study of sorafenib versus SBRT followed by sorafenib in HCC (RTOG1112) is planned. Randomized clinical trials in the Asia-Pacific region for sorafenib versus RT combined with sorafenib, similar to the SHARP trial and Asia-Pacific trial for sorafenib, are warranted.

The strength of evidence according to study design or end-points on multimodality management for BCLC stage C (advanced stage) HCC is weak. Although there are many retrospective studies on multimodality management for HCC of this stage, there are few studies in the form of phase I and II trials. As a result, a consensus for managing BCLC stage C HCC cannot be easily established. Thus, randomized controlled clinical trials or meta-analyses of randomized studies on multimodality management suitable for BCLC stage C HCC should be actively pursued. The consensus for successful management of BCLC stage C HCC using a multimodal approach should be further discussed at the upcoming APPLE meeting.

The authors report no potential conflicts of interest.

This work was supported by a grant (0620390) from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea.

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