La aspergilosis broncopulmonar alérgica (ABPA) es una enfermedad inflamatoria de las vías respiratorias, de origen inmunitario, que afecta principalmente a pacientes con fibrosis quística (FQ) y, con menor frecuencia, a pacientes con asma. La ABPA puede causar lesiones pulmonares irreversibles y bronquiectasias si no se trata de forma temprana y activa. Los esteroides orales a largo plazo, el tratamiento estándar para la ABPA, se asocian con un riesgo mayor de efectos secundarios y un posible incumplimiento de la medicación. Se ha utilizado un bolo mensual de metilprednisolona intravenosa (IV-PS) como alternativa a los esteroides orales para tratar la ABPA vinculada con la FQ, y se ha reportado una respuesta clínica similar y menos efectos secundarios relacionados con los esteroides. Hasta donde sabemos, no se ha reportado el uso de la IV-PS en la ABPA asociada con asma. Presentamos el tratamiento exitoso de ABPA relacionada con asma en un adolescente, utilizando un bolo de metilprednisolona intravenosa combinado con itraconazol oral, sin efectos secundarios significativos debidos a los esteroides.

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