... the effect of SGLT2i on the urinary podocyte-associated molecule levels in DKD. Methods: We studied 24 DKD patients who were started on SGLT2i treatment and 25 patients who were not treated (control group). Urinary levels of podocyte-associated molecules, their corresponding mRNA levels in urinary sediment...

...Yuting Li; Jiaojiao Fan; Wenping Zhu; Yujia Niu; Wu; Aihua Zhang Background: Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration function of the glomerulus. Podocyte injury under various stress conditions is the primary pathogenesis...

... major advances, since the discovery of the phospholipase A2 receptor as the major autoantigen of podocytes in MN, the mechanisms leading to glomerular damage remain elusive. Pyroptosis, a newly discovered type of programed necrotic cell death mainly mediated by gasdermin, was found to be responsible...

...Yu Sun; Sijia Cui; Yunfeng Hou; Fan Yi Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier. Podocyte injury is considered as the most...

..., instructions or products referred to in the content or advertisements. Autophagy Lysosome Kidney disease Tubular epithelial cell Podocyte Macroautophagy is an evolutionarily conserved lysosome-dependent catabolic process that sequesters the cytoplasmic materials, such as protein aggregates...

... as a renal disease indicator is dampened by the difficulty to ascertain their cell source. Objectives: The aim of this study was to demonstrate that podocytes can release migrasomes, a unique class of microvesicle with size ranging between 400 and 2,000 nm, and the urine level of migrasomes may serve...

... kidney function. Diabetes, hypertension, and any primary or secondary glomerulopathy may threaten the normal glomerular function. In fact, any glomerular insult may alter the glomerular filtration barrier, which in turn is composed by the podocyte, the glomerular basement membrane, and the capillary...

...Min Zhao; Mi Bai; Guixia Ding; Yue Zhang; Songming Huang; Zhanjun Jia; Aihua Zhang Background: We previously reported that the NLRP3 inflammasome played an important role in mediating the podocyte injury induced by aldosterone. However, more studies on the role of the NLRP3 inflammasome...

... in hereditary podocytopathies. Moreover, it has revealed mutations in unexpected genes and has widened the phenotypes associated with podocyte gene mutations. The list of genes mutated in hereditary podocytopathies is constantly evolving and consists to date of more than 40 genes. However, the most recently...