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Keywords: Mitochondrial dysfunction
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Journal Articles
Subject Area:
Nephrology
Mingsheng Zhu, Xian Ling, Shan Zhou, Ping Meng, Qiyan Chen, Shuangqin Chen, Kunyu Shen, Chao Xie, Yaozhong Kong, Maosheng Wang, Lili Zhou
Journal:
Kidney Diseases
Kidney Dis (2022) 8 (5): 408–423.
Published Online: 27 September 2022
...Mingsheng Zhu; Xian Ling; Shan Zhou; Ping Meng; Qiyan Chen; Shuangqin Chen; Kunyu Shen; Chao Xie; Yaozhong Kong; Maosheng Wang; Lili Zhou Introduction: Aged kidney is characterized by mitochondrial dysfunction, cellular senescence, and fibrogenesis. The activation of Wnt/β-catenin signaling plays...
Journal Articles
Subject Area:
Nephrology
Mingzhu Jiang, Min Zhao, Mi Bai, Juan Lei, Yanggang Yuan, Songming Huang, Yue Zhang, Guixia Ding, Zhanjun Jia, Aihua Zhang
Journal:
Kidney Diseases
Kidney Dis (2021) 7 (4): 293–305.
Published Online: 10 March 2021
... in podocyte-specific Sirt1 knockout mice than in the wild-type mice. Moreover, podocyte conditional Sirt1 knockout aggravated NLRP3 inflammasome activation and mitochondrial dysfunction (MtD). In vitro, overexpression of SIRT1 inhibited NLRP3 activation, protected against MtD and podocyte injury. Conclusion...
Journal Articles
Subject Area:
Nephrology
Journal:
Kidney Diseases
Kidney Dis (2018) 4 (2): 83–94.
Published Online: 22 May 2018
... podocytes, we used siRNA to silence NLRP3; then we treated the podocytes with Ang II. Results: Following Ang II treatment, we found that the NLRP3 inflammasome was significantly activated in line with mitochondrial dysfunction in a dose- and time-dependent manner. Silencing NLRP3 by siRNA transfection...