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Keywords: Klotho
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Journal Articles

The Protective Role of Klotho in CKD-Associated Cardiovascular Disease

Open Access
Subject Area:
Nephrology
Xianjin Bi, Ke Yang, Bo Zhang, Jinghong Zhao
Journal: Kidney Diseases
Kidney Dis (2020) 6 (6): 395–406.
https://doi.org/10.1159/000509369
Published Online: 19 August 2020
... and fibrosis, as well as accelerated atherosclerosis. α-Klotho is proposed as an anti-aging gene, which is primarily expressed in the kidney. Recent studies reveal that α-Klotho deficiency is associated with profound cardiovascular dysfunction. Of note, CKD represents extremely declined α-Klotho levels...
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Journal Articles

Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease

Available to Purchase
Subject Area:
Nephrology
Xiang Lu, Ming Chang Hu
Journal: Kidney Diseases
Kidney Dis (2017) 3 (1): 15–23.
https://doi.org/10.1159/000452880
Published Online: 17 November 2016
...Xiang Lu; Ming Chang Hu Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. FGF23 is produced in bones and participates...
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