...Zhuo Sun; Xiaotong Shao; Haotian Wu; Yaxian Zhao; Yidan Cao; Danhua Li; Ying Sun; Qingling Wang Introduction: Phosphatase and tensin (PTEN) is a multifunctional gene associated with the normal development and physiological function of various tissues including the kidney. However, its role in renal...

...Yashwanth Reddy Sudhini; Changli Wei; Jochen Reiser Background: Inflammation is a common feature of many kidney diseases. The implicated inflammatory mediators and their underlying molecular mechanisms however are often not clear. Summary: suPAR is the soluble form of urokinase-type plasminogen...

... with kidney disease. The aim of this study was to investigate the pathological spectrums and the renal prognosis of AS patients with kidney disease. Methods: This retrospective and observational study was conducted working on 62 patients (47 males and 15 females) with a diagnosis of AS (ACR, 1984) and renal...

... and mechanisms of FGFR2 signaling in tubular cell survival and acute kidney injury (AKI). Method: In this study, kidney ischemia/reperfusion (IR) or cisplatin injection was used to induce AKI in mice. Results: In the kidneys after IR or cisplatin injection, the expression of FGFs and Erk1/2 phosphorylation were...

... Immunoglobulin G Kidney Systemic vasculitis Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis, microscopic polyangiitis, and renal limited AAV, are multisystemic severe autoimmune diseases [ 1 ]. Histological proof of vasculitis remains...

...Yuting Ye; Hui Song; Jiong Zhang; Shaolin Shi Background: Single-cell RNA-seq (scRNA-seq) has recently emerged as a revolutionary and powerful tool for biomedical research. However, there have been relatively few studies using scRNA-seq in the field of kidney study. Summary: scRNA-seq achieves gene...

...Ye Feng; Yan Liang; Jiafa Ren; Chunsun Dai Background: Wnt/β-catenin, an evolutionary conserved signaling pathway, plays an essential role in modulating kidney injury and repair. Our previous studies demonstrated that Wnt/β-catenin signaling could stimulate macrophage M2 polarization and contribute...

...Hanieh Shaterzadeh-Yazdi; Mohammad-Foad Noorbakhsh; Saeed Samarghandian; Tahereh Farkhondeh Background: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney...

...Zhuo Xu; Chunsun Dai Background: Fibroblast growth factors (FGFs) are heparin-binding proteins involved in a variety of biological processes. However, the role and mechanisms of FGF/FGFR2 signaling in fibroblast activation and kidney fibrosis need further investigation. Methods: In this study...