...Qimei Luo; Xi Xia; Qingqing Luo; Yue Qiu; Lan Dong; Chen Zhao; Fenfen Peng; Jing Yu; Fengxian Huang; Feng He Aim: The aim of this study was to investigate the role and mechanism of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3)-205 in renal inflammation and fibrosis in diabetic...

... to kidney fibrosis. However, whether canonical Wnt signaling activation leads to macrophage proliferation during kidney fibrosis remains to be determined. Methods: In this study, a mouse model with macrophage-specific β-catenin gene deletion was generated and a unilateral ureter obstruction (UUO) model...

... kidney injury Chronic kidney disease Fibrosis Inflammation Tubulointerstitial nephritis A critical factor in the development of renal CCEs is the formation of an atherosclerotic lesion. Spontaneous or iatrogenic rupture of plaques in the thoracic aorta or renal arteries results in showers of CCs...

...Zhuo Xu; Chunsun Dai Background: Fibroblast growth factors (FGFs) are heparin-binding proteins involved in a variety of biological processes. However, the role and mechanisms of FGF/FGFR2 signaling in fibroblast activation and kidney fibrosis need further investigation. Methods: In this study...

... and repair process. However, unresolved inflammation and uncontrolled wound healing processes can trigger the process of renal fibrosis by enhancing activation and differentiation of macrophages. Fig. 1. Macrophage phenotypes in renal injury and repair. During renal inflammation, circulating monocytes...