... role in kidney injury progression. Although serum and urinary KIM-1 levels are established biomarkers for kidney damage, the relationship between KIM-1 levels, HAVCR1 gene polymorphism, and chronic kidney disease (CKD) stages remains unclear. This study aimed to investigate KIM-1 as a potential...

... disease Podocyte Proteinuria Diabetic kidney disease (DKD) is the leading cause of dialysis-dependent chronic kidney disease, with albuminuria as a key symptom of nephropathy. DKD progresses due to glomerular filtration barrier (GFB) damage and the loss of podocytes [ 1, 2 ]. As type 2 diabetes...

... decades, it has significantly improved survival rates for patients with hematological disorders [ 1 ]. However, renal impairment is a prevalent complication associated with HSCT, encompassing both acute kidney injury (AKI) and chronic kidney disease (CKD). Previous studies indicate that the incidence...

...Yuchu Liu; Zeyu Li; Yuanwen Xu; Haiping Mao; Naya Huang Background: Chronic kidney disease (CKD) is a prevalent global health concern, significantly linked to increased cardiovascular morbidity and mortality. Among various risk factors, uric acid (UA) has emerged as a potentially modifiable...

...Sang Heon Suh; Tae Ryom Oh; Hong Sang Choi; Chang Seong Kim; Eun Hui Bae; Seong Kwon Ma; Kook-Hwan Oh; Kyu-Beck Lee; Ji Yong Jung; Soo Wan Kim; Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Investigators Introduction: Despite the pivotal role of hepcidin...

... in key cell-cell signaling events essential for development and regeneration. Congenital anomalies of the kidney and urinary tract (CAKUT) represent a leading cause of chronic kidney disease in children and young adults, and include a variety of birth abnormalities resulting from disrupted genitourinary...

... mitochondria, it is particularly crucial to control mitochondrial quality through mitophagy. Dysregulation of mitophagy has been associated with various renal diseases, including acute and chronic kidney diseases, and therefore a better understanding of the links between mitophagy and these diseases may...

...Yingjing Shen; Chen Yu Background: The bone-vascular axis plays a key role in the pathogenesis of vascular calcification (VC) in patients with chronic kidney disease (CKD). Understanding and managing the role of the bone-vascular axis in CKD-mineral and bone disorder (CKD-MBD) is critical...

...Philip Kam-Tao Li; Jack Kit-Chung Ng; Guang-yan Cai; Wei Chen; Kai Ming Chow; Stanley Fan; John Cijiang He; Lai Seong Hooi; York Pei; Boon Wee Teo; Muh Geot Wong; I-Wen Wu; Jianhui Zhou; Na Tian; Zhiming Ye; Xueqing Yu Background: Chronic kidney disease (CKD) continues to be a significant global...

... through classical pathways, and IL-18 mediates inflammation and activates gasdermin-D protein to induce cellular pyroptosis. Numerous studies have also emphasized the non-classical pathway activated by the NLRP3 inflammasome in chronic kidney disease (CKD) and the inflammasome-independent function...

... with chronic kidney disease (CKD). Methods: Five different ML models were trained to predict the risk of ESKD and CVD at three different time points (3, 5, and 8 years) using a cohort of 400 non-dialysis CKD patients. The dataset was divided into a training set (70%) and an internal validation set (30...

...Yudian Wang; Xiaoyong Yu Background: Anemia is one of the common complications of chronic kidney disease (CKD), and its prevalence has been arising globally. The key cause of anemia in CKD patients is the diseased kidney’s reduced ability to synthesize endogenous erythropoietin (EPO), yet...

...Xiao-Yu Cai; Wei-Lan Li; Shu-Wang Ge; Gang Xu Introduction: Peripheral neuropathy (PN), one of the commonest neurological complications of chronic kidney disease (CKD), was associated with physical limitation. Studies showed that a decrease in physical capability in patients with CKD is related...

...Ilya Losin; Keren-Cohen Hagai; David Pereg Background: Chronic kidney disease (CKD) is associated with a high burden of coronary artery disease (CAD), which remains the leading cause of death in CKD patients. Despite the high cardiovascular risk, ACS patients with renal dysfunction are less...

... system (RAS) inhibitors for secondary prevention in patients with chronic kidney disease (CKD) and coexisting coronary artery disease remains unclear. Methods: Altogether, 1,160 consecutive patients with CKD (mean age, 70 ± 9 years; 78% men) who underwent their first percutaneous coronary intervention...

...Xue Wang; Cuiting Wei; Delong Zhao; Xuefeng Sun; Fengge Zhu; Yan Mei; Qian Ma; Guangyan Cai; Xiangmei Chen; Ping Li Background: Anemia is a common and important complication in patients with chronic kidney disease (CKD). Accordingly, the current treatment is based on erythropoiesis-stimulating...

... of finerenone in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) in China. Methods: 372 participants were recruited from 67 centers in China and randomized 1:1 to oral finerenone or placebo with standard therapy for T2DM. The primary composite outcome included kidney failure...

... cognition in chronic kidney disease (CKD) patients and the dysfunction of the glymphatic system. Method: Data were obtained from 77 CKD patients and 50 age-matched healthy control individuals from the First Affiliated Hospital of Zhengzhou University. CKD patients were stratified into with and without...

...Jing Liu; Yunying Shi; Yongshu Diao; Xiaoxi Zeng; Ping Fu Background: Chronic kidney disease (CKD) is an incurable disease requiring lifelong management. China has a high prevalence of CKD, which disproportionately affects older adults and those with chronic risk factors for CKD development...

... benefits in reducing mortality and delaying the progression of chronic kidney disease (CKD) in both diabetic and nondiabetic patients. Thus, we herein review the current evidence regarding the efficacy and safety of SGLT2i in patients with nondiabetic CKD and appraise the recently reported clinical trials...