... Cisplatin Acute kidney injury Inflammation Oxidative stress Apoptosis Necroptosis Acute kidney injury (AKI) is a group of syndromes defined by an abrupt decrease in glomerular filtration [ 1, 2 ]. AKI is a worldwide public health problem which is estimated to occur in about 20–200 per million...

...Weiteng Wang; Jieyi Luo; Yingwen Chen; Huaban Liang; Zhilian Li; Yuanhan Chen; Jintao He; Xinling Liang Introduction: Various types of acute kidney injury (AKI) are associated with triglyceride (TG) accumulation in renal tubular epithelial cells, but the role and mechanisms of TG accumulation...

...Nam Nguyen-Hoang; Wenbo Zhang; Jacqueline Koeze; Harold Snieder; Eric Keus; Gerton Lunter Introduction: Among critically ill patients, acute kidney injury (AKI) has a high incidence and leads to poor prognosis. As AKI is often only detected well after onset, early risk stratification is crucial...

... cytoplasmic antibody-associated glomerulonephritis Acute kidney injury Fatty acid-binding protein 4 Renal function Urinary biomarker Antineutrophil cytoplasmic antibodies (ANCAs)-associated vasculitis (AAV) is a group of systemic autoimmune diseases characterized by necrotizing inflammation...

... holds promise, most mitophagy-centered therapeutic approaches have yet to reach the clinical application stage. Mitophagy Chronic kidney disease Acute kidney injury Parkin Alport syndrome Mitochondria play a vital role in various cellular processes, including ATP production, lipid...

.... However, the role of TAZ in tubular cell survival and acute kidney injury (AKI) remains largely unknown. Methods: We used the RNA-seq database, Western blot, and immunohistochemistry to examine TAZ expression in kidneys from cisplatin-induced AKI. We generated tubular-specific TAZ knockout mice to assess...

...Lingxi Guo; Xiaojing Wu; Xiaoyang Cui; Meiyuan Li; Lu Yang; Yiming Feng; Qingyuan Zhan; Linna Huang Introduction: The incidence and impact of acute kidney injury (AKI) in patients with invasive pulmonary aspergillosis (IPA) admitted to the intensive care unit (ICU) are unknown. Methods...

...Jiaying Li; Fangxing Hou; Ning Lv; Ruohuan Zhao; Lei Zhang; Cai Yue; Min Nie; Limeng Chen Background: Acute kidney injury (AKI) is a severe condition marked by rapid renal function deterioration and elevated mortality, with traditional biomarkers lacking sensitivity and specificity. Rare...

...Liangjing Lv; Jiachuan Xiong; Yinghui Huang; Ting He; Jinghong Zhao Introduction: The triglyceride glucose (TyG) index is a reliable alternative biomarker of insulin resistance, but the association between the TyG index and acute kidney injury (AKI) in critically ill patients remains unclear...

...Jiachuan Xiong; Jinghong Zhao Background: Acute kidney injury (AKI) is kidney damage that leads to a rapid decline in function. AKI primarily occurs when the tubular epithelium is damaged, causing swelling, loss of brush margin, and eventual apoptosis. Research has shown that tubular epithelial...

... Gong; Fan Fan Hou; Xin Xu Introduction: Comprehensive data on the risk of hospital-acquired (HA) acute kidney injury (AKI) among adult users of opioid analgesics are lacking. This study aimed to systematically compare the risk of HA-AKI among the users of various opioid analgesics. Methods...

... of mitochondria in maintaining normal kidney function and in the pathogenesis of various renal diseases, including acute kidney injuries (AKIs) and chronic kidney diseases (CKDs). Summary: Under physiological conditions, fine-tuning mitochondrial energy balance, mitochondrial dynamics (fission and fusion...

...Jiaxiao Li; Junzhe Chen; Hui-yao Lan; Ying Tang Background: C-reactive protein (CRP) is an acute-phase protein and has been found to be a risk factor for acute kidney injury (AKI) and chronic kidney diseases (CKD). However, the role and mechanisms of CRP in AKI and CKD remain largely unclear...

...Christina Montgomerie; Jonas Spaak; Marie Evans; Stefan H. Jacobson Introduction: Complex integrated information on disease mechanisms and in-hospital outcomes in mild to moderate acute kidney injury (AKI) is scarce. Methods: The Stockholm Prospective AKI Cohort Study (SAKIS) included all patients...

...Wenjuan Yang; Tao Peng; Chunli Shi; Fang Cui; Menghua Chen; Ting Zhang Introduction: Renal ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury, and its mechanism is complex involving multiple factors, while delayed ischemic preconditioning (DIPC) has a protective...

...Jun Wang; Fengchen Shen; Feng Liu; Shougang Zhuang Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged...

..., instructions or products referred to in the content or advertisements. Growth factors Chronic kidney disease Acute kidney injury Clinical trials Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have become a global public health concern associated...

...Lirui Wang; Jiangtao Li; Chen Yu Background: Sepsis causes acute kidney injury (AKI) in critically ill patients, although the mechanisms underlying the pathophysiology are not fully understood. SUMO-specific proteases 3 (SENP3), a member of the deSUMOylating enzyme family, is known as a redox...

... or combined immunosuppressant use based on disease stage; however, there is no consensus on renal biopsy. Key Messages: Despite significant progress in prevention and treatment, the incidence and mortality of ICI-induced acute kidney injury (AKI) remain very high. This article will discuss the general...

...Zhao-Ying Ding; Tao-Tao Tang; Zuo-Lin Li; Jing-Yuan Cao; Lin-Li Lv; Yi Wen; Bin Wang; Bi-Cheng Liu Introduction: Acute kidney injury (AKI) is a major public health problem worldwide. However, there is no definitive therapies to treat established AKI. In this study, we used FG-4592 to induce hypoxia...