..., addressing the detrimental environment that fosters plaque vulnerability, reducing chronic low-grade inflammation, and normalizing mineral metabolism markers (such as vitamin D and PTH) and bone-regulating molecules may emerge as a viable therapeutic strategy. Patients were included between 2004 and 2018...

... of policosanol (Poli), genistein (Gen), and vitamin D (VitD) separately and in association to evaluate the possible synergistic action on inorganic phosphate (Pi)-induced calcification of vascular smooth muscle cells (VSMCs). Methods: Primary human VSMCs were cultured with either growth medium or growth medium...

... of vitamin D on podocyte injury of DKD. Methods: Type 2 diabetic db/db mice received intraperitoneal injections of vitamin D analog paricalcitol 400 ng/kg per day for 16 weeks. Immortalized mouse podocytes were cultured in high glucose (HG) medium with active vitamin D3 calcitriol or autophagy inhibitor 3...

...David Galuška; Lukáš Pácal; Kateřina Kaňková Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well...

... investigated the association between vitamin D level and muscle mass or strength in patients undergoing HD. However, there are conflicting results regarding this association. Objective: To evaluate the association between vitamin D level and muscle mass indices, strength, or physical performance in patients...

...Yangyang Wang; Shikun Yang; Qianying Zhou; Hao Zhang; Bin Yi Background/Aims: Vitamin D (VD) is widely recognized as renal protective. However, whether VD supplementation provides benefit to patients with diabetic nephropathy (DN) remains controversial. Here, we performed a meta-analysis...

...Alicja E. Grzegorzewska; Agnieszka Izdebska; Leszek Niepolski; Wojciech Warchoł; Paweł P. Jagodziński Background/Aims: Vitamin D status is announced among factors that may influence physical performance and mental health. Our aim was to evaluate self-reported physical activity, quality of life...

...Elisabeth Lang; Kashif Jilani; Rosi Bissinger; Rexhep Rexhepaj; Christine Zelenak; Adrian Lupescu; Florian Lang; Syed M. Qadri Background/Aims: Epidemiological evidence suggests that vitamin D deficiency is associated with anemia. The potent metabolite 1,25(OH) 2 vitamin D 3 [1,25(OH) 2 D 3...

... inhibitor) and paricalcitol (vitamin D receptor activator) on cardiac and renal parameters. The effects of the individual and combined drugs were examined after a 3-month treatment. Results: A decrease in systolic blood pressure, serum creatinine and proteinuria, and improvement of renal histology in uremic...

...Christoph Reichetzeder; Hong Chen; Michael Föller; Torsten Slowinski; Jian Li; You-Peng Chen; Florian Lang; Berthold Hocher Background/Aims: Cardiovascular disease partially originates from poor environmental and nutritional conditions in early life. Lack of micronutrients like 25 hydroxy vitamin D...

..., vitamin D also contributes to other systems, including the immune, cardiovascular and endocrine systems. Vitamin D analogs reduces proteinuria, in particular through suppression of the renin-angiotensin-aldosterone system (RAAS) and exerts anti-inflammatory and immunomodulatory effects. In particular...

... mineralization, cell proliferation, immune response, carbohydrate metabolism, blood pressure, platelet reactivity, gastric acid secretion, cognitive function and mood. Calcitriol is mainly effective by stimulation of the Vitamin D receptor VDR. The responsiveness of VDR may be affected by gene variants...

...José Pedro L. Nunes Background: Elevated plasma cardiac troponin, elevated plasma phosphorus and decreased plasma vitamin D have been shown to be associated with negative outcomes. Methods and results: Troponin I, calcium, phosphorus and 25-OH vitamin D were studied in a cohort of 60 patients...

...Charumathi Sabanayagam; Anoop Shankar; Shanmugasundaram Somasundaram Background: Low serum vitamin D levels are associated with high blood pressure (BP). Prehypertension is a preclinical stage where primary prevention efforts have been recommended for delaying or preventing the onset...

... stimulated by high phosphate, and more recently the role of the calcium phosphate nanocrystals has gained attention. Experimental models of uremia and in vitro studies have shown that an excess of calcitriol accelerates vascular calcification. However, observational studies suggest that vitamin D provides...

.... The relationship between vitamin D and CVD has been explored more recently. Negative correlations between vitamin D levels and the risk of hypertension, myocardial infarction, and stroke have been reported in several observational studies. The effect of vitamin D supplementation on blood pressure is still unclear...

... of laboratory and clinical (hospitalization rate, clinical complaints questionnaire) responses to 12-month cinacalcet treatment. Treatment patterns and cost (including phosphate binders, vitamin D, and cinacalcet) were evaluated. Results: The mean s-Ca dropped significantly from 2.36 ± 0.24 to 2.21 ± 0.20 mmol...

...Z. Weinreich; A. Müller; R.P. Wüthrich; C. Booy; U. Binswanger Apart from its classical role in bone and mineral metabolism, 1,25-dihydroxyvitamin D 3 (1,25-vitamin D 3 ) has recently been shown to affect cell growth and differentiation from a variety of tissues primarily not involved in mineral...

..., and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involved have not been fully identified. We asked whether 1,25-vitamin D 3 might interact with additional immunoregulatory functions of renal cells by studying its effects on the expression of the cellular adhesion...

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