...Carla Iacobini; Valeria Fassino; Sandro Mazzaferro; Lida Tartaglione Introduction: The process of vascular calcification has severe clinical consequences in a number of diseases, including diabetes, atherosclerosis, and end-stage renal disease. In the present study, we investigated the effect...

...Dai Deng; Xue Han; Zongli Diao; Wenhu Liu Introduction: Vascular calcification (VC) is highly prevalent and a major cardiovascular risk factor in chronic kidney disease (CKD) patients. Secreted frizzled-related protein 5 (SFRP5), an inhibitor of the Wnt pathway, is an adipokine with a positive...

... in vascular calcification in patients with ESRD. The present study investigated the role and mechanism of hyperoxalemia in vascular calcification in mice with uremia. Methods: A uremic atherosclerosis (UA) model was established by left renal excision and right renal electrocoagulation in apoE −/− mice...

...Linzi Han; Yuying Zhang; Mingming Zhang; Liyu Guo; Jun Wang; Fanjun Zeng; Deping Xu; Zongzhi Yin; Yuanhong Xu; Deguang Wang; Haisheng Zhou Introduction: Interleukin (IL)-1β, as a key biomarker and mediator of vascular calcification in patients with end-stage renal disease (ESRD), may be involved...

... and nontraditional risk factors as well as uremia-related factors and transplant-specific factors, leading to 2 differentiated processes under the framework of CKD, atherosclerosis and arteriosclerosis. These can be initiated by insults to the vascular endothelial endothelium, leading to vascular calcification (VC...

... of osteoblast function and decreases bone formation and mineralization [ 13 ]. Recent studies indicate that sclerostin may exert similar actions in the vascular wall, thereby inhibiting vascular calcification [ 14, 15 ]. FGF-23 is a key regulator of phosphate homeostasis and a powerful cardiovascular risk...

...Toshihide Naganuma; Yoshiaki Takemoto; Junji Uchida; Tatsuya Nakatani; Daijiro Kabata; Ayumi Shintani Background/Aims: Vascular calcification is common and progressive in chronic kidney disease, including kidney transplant recipients (KTRs). However, the risk factors associated with the progression...

..., instructions or products referred to in the content or advertisements. Arterial stiffness Pulse wave velocity Coronary calcification Vascular calcification Chronic kidney disease Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD) [ 1...

... inversely associated with AoAC severity, and FGF-23was directly related to vascular calcification. Age, gender, and dialysis vintage were independent predictors of AoAC. Conclusion: MHD patients have a high prevalence of AoAC. The grade of AoAC was dependent on older age in association with longer dialysis...

...Beate Boehme; Nadeshda Schelski; Manousos Makridakis; Laura Henze; Antonia Vlahou; Florian Lang; Burkert Pieske; Ioana Alesutan; Jakob Voelkl Background/Aims: Hyperphosphatemia promotes medial vascular calcification, at least partly, by induction of osteo-/chondrogenic transdifferentiation...

...; Shuangxin Liu Background/Aims: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in hemodialysis patients. Vascular calcification is thought to play an important role in causing CVD. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker strongly predictive...

...) with adverse cardiovascular outcomes, in Chronic Kidney Disease (CKD) patients has previously been reported and may be a result of increased vascular calcification and inflammation. Here we report, for the first time, the effects of pharmacologic epigenetic modulation on levels of ALP and kidney function via...

...Lian He; Wan-Yu He; La-Ta A; Wen-Ling Yang; Ai-Hua Zhang Background/Aims: Vascular calcification, which involves an active cellular transformation of vascular smooth muscle cells into bone forming cells, is prevalent and predicts mortality in dialysis patients. Its mechanisms are complex...

... and clinical studies have found that high serum phosphate concentrations are associated with calcification in the coronary arteries. However, the mechanisms underlying the vascular calcification induced by high phosphate have not been understood fully. Methods: Vascular smooth muscle cells (VSMCs) were...

...Eiji Ishimura; Senji Okuno; Hisanori Okazaki; Kyoko Norimine; Kenjiro Yamakawa; Tomoyuki Yamakawa; Shigeichi Shoji; Yoshiki Nishizawa; Masaaki Inaba Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association...

...Carlo Basile; Carlo Lomonte; Piero Lisi; Cristina Karohl; Biagio Di Di Iorio; Antonio Bellasi Vascular calcification (VC) is a prominent feature that affects up to 40 to 80% of Chronic Kidney Disease (CKD) patients depending on the degree of renal impairment. Though etiology and pathogenesis...

...Won Suk An; Su Mi Lee; Tae Ho Park; Seong Eun Kim; Ki Hyun Kim; Young Jin Park; Young Ki Son Background/Aim: Diastolic dysfunction is frequently associated with left ventricular hypertrophy, which is indicative of future cardiovascular events. Vascular calcification (VC) is known to be associated...

...So-Young Lee; Hoe-Young Kim; Seung Won Gu; Hyung-Jong Kim; Dong Ho Yang Background/Aims: The role of vitamin D in the process of vascular calcification is unclear in patients with chronic kidney disease. We investigated whether serum 25-hydroxyvitamin D [25(OH)D] is associated with vascular...

...Mariano Rodriguez; Julio Manuel Martinez-Moreno; M. Encarnación Rodríguez-Ortiz; Juan R. Muñoz-Castañeda; Yolanda Almaden Vascular calcification is common in patients with chronic kidney disease (CKD) and contributes to the increased rate of cardiovascular morbidity and mortality. The mechanisms...

...Takafumi Okura; Mie Kurata; Daijiro Enomoto; Masanori Jotoku; Tomoaki Nagao; Veena Rasika Desilva; Jun Irita; Ken-Ichi Miyoshi; Jitsuo Higaki The development of vascular calcification is an active, highly regulated process with similarities to bone formation. Osteocalcin (OC), a vitamin K-dependent...