...Xiao Wang; Jie-Hao Zhou; Guang Chen; Ji-Dong Chen; Hui Li; Wei-Min Shan; Wei-xiao Li Background: Renal fibrosis is a key driver of chronic kidney disease, often leading to end-stage renal disease (ESRD). Secreted phosphoprotein 1 (Spp1) is implicated in fibrotic processes, but its specific role...

... failure. Hypertension leads to complement deposits and renal fibrosis in the kidney. Therefore, the aim of this study was to investigate whether increased complement deposits and fibrosis can be observed in grafts of hypertensive compared to normotensive living donors. Methods: Zero-time renal biopsies...

...Samaneh Goorani; Abdul Hye Khan; Abhishek Mishra; Ashraf El-Meanawy; John D. Imig Introduction: Renal fibrosis is a critical event in the development and progression of chronic kidney disease (CKD), and it is considered the final common pathway for all types of CKD. The prevalence of CKD is higher...

... factor leading to renal fibrosis and chronic kidney disease. Pterostilbene has been reported to display lipid-lowing activity and participate in many kidney diseases. However, the influence of pterostilbene on the ectopic lipid deposition is unclear. We intend to explore the influence of pterostilbene...

... collected from db/db mice, but its specific role in diabetic nephropathy was still unclear. This study aimed to explore the effect of miR-494-3p on renal fibrosis using an in vitro cell model of diabetic nephropathy. Methods: After human renal tubular epithelial cells (HK-2) were treated with high glucose...

... downstream targets of lncRNA ENST00000453774.1 (lnc453774.1) and outline their functions on the development of renal fibrosis. Methods: HK-2 cells were induced with 5 ng/mL TGF-β1 for 24 h to construct a renal fibrosis cell model. Differentially expressed genes (DEGs) targeted by lnc453774.1 in TGF-β1...

... to in the content or advertisements. Renal fibrosis Tumor-suppressing STF cDNA 3 Transforming growth factor beta 1 HK-2 cells Phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B signaling pathway All experiments were performed in triplicate, and data are shown as the mean ± SD...

.... The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmonary fibrosis are well established, but the therapeutic potential of rhTM in renal fibrosis remains poorly understood. Methods: Nephrotoxic serum nephritis (NTS-N) was induced in 22 female Wistar-Kyoto (WKY) rats on day 0. Rats were...

... accurately indicate the renal fibrosis and renal injury in HFD-fed mice treated with lovastatin . Conclusion: This study seems to confirm the utility of a noninvasive and repeatable ultrasound parameter to rapidly evaluate renal fibrosis in a HFD-induced type 2 diabetic mouse model in vivo . This highly...

...Xiangchen Gu; Dechao Xu; Lili Fu; Yi Wang; Changlin Mei; Xiang Gao Background/Aims: Angiotensin II (Ang II) has been regarded as an important profibrogenic cytokine in renal fibrosis. Krüppel-like factor 15 (KLF15) has been identified as an important negative transcription factor in renal fibrosis...

...Jian Zhang; Pingping Ren; Yucheng Wang; Shi Feng; Cuili Wang; Xiujin Shen; Chunhua Weng; Xiaobing Lang; Zhiming Chen; Hong Jiang; Jianghua Chen Background/Aims: In view of the latest findings that matrix metalloproteinase-7 (MMP-7) acted as a vital marker and pathogenic mediator of renal fibrosis...

... fatty acids (FFA). Results: Compared with the chow diet group, HFD-fed WT mice had higher urinary albumin and increased levels of renal fibrosis, glomerulosclerosis, inflammation, oxidative stress and apoptosis in the kidney. These changes were co-related with increased expression of TNF-α in the kidney...

...Nan Sun; Lei Zhai; Hui Li; Li-Hua Shi; Zhi Yao; Bo Zhang Background/Aims: The mechanism by which angiotensin-converting enzyme inhibitors (ACEIs) attenuate renal fibrosis has not been fully uncovered. Methods: Renal fibrosis in rats was triggered by unilateral ureteral obstruction (UUO) and treated...

...Dan Zhu; Linlin Zhang; Lijuan Cheng; Liansheng Ren; Jie Tang; Dianjun Sun Background/Aims: We aimed to evaluate whether pancreatic kininogenase (PKase) can relieve renal fibrosis and investigate its mechanisms in diabetic nephropathy (DN) rats Methods: We established streptozotocin (STZ) induced-DN...

... obstructive nephropathy. The development of renal fibrosis following unilateral ureteral obstruction (UUO) is blunted in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. Similar to Akt isoforms, SGK1 phosphorylates and thus inactivates glycogen synthase kinase GSK-3...

... Renal fibrosis Transforming growth factor- 1 Oxidative stress Matrix metalloproteinases ADAMTS Tissue inhibitors of metalloproteinases Abstract Background: 5/6 nephrectomy (Nx) in susceptible animals causes glomerular sclerosis and interstitial fibrosis in the remnant kidney. Oxidative stress...

... (uMCP-1) chemokine is increased in several proteinuric and/or inflammatory renal diseases. In the present study, we evaluated the association between uMCP-1 and renal function, proteinuria, glomerular and interstitial macrophage infiltration, and renal fibrosis in patients with primary and secondary...

...Ana M. Rodríguez-López; Olga Flores; Miguel A. Arévalo; José M. López-Novoa In the present study, we measured tubular cell apoptosis and proliferation and Bcl-2 expression during the early phase (3 months) of the process of renal fibrosis in the experimental model of uninephrectomized spontaneously...