... of isolated renal tubular segments to this agent. In proximal tubules, 4P inhibited the activity of α-ketoglutarate dehydrogenase, pyruvate dehydrogenase, and β-oxidation, but not in thick ascending limb or inner medullary collecting duct tubules in suspension. These proximal effects were accompanied...

... to determine if they have specific binding sites on distal nephrons, proximal tubules, renal cortical and medullary membranes. Competitive binding experiments revealed that proANFs 1-30, 31-67, and 99-126 (i.e., C-terminus; ANF) each had specific and separate binding sites. The dissociation constants (K d...

...Klaus Thomsen; Marie Karoline Zanoni; Sten Christensen The accumulating evidence that the delivery of fluid from the proximal tubules to the loop of Henle (V prox ) can be measured in conscious rats by the lithium clearance (C Li )technique has renewed interest in developing a method by which also...

... of dog renal proximal tubules (Percoll). This raises specific problems due to the accumulation of BCECF in the extracellular compartment generated by desesterification of BCECF-AM during loading and to leaking of BCECF into the extracellular medium occurring during the waiting time and during...

...) is a glycosylphosphatidylinositol–anchored ectoenzyme within the renal proximal tubules (PTs) and is proposed as a diagnostic enzyme of renal disease. We examined the release of RDPase following treatment with CB and various nitric oxide (NO) related compounds in porcine PTs. The RDPase release from PTs was inhibited by CB...